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The map label for this gene is hisB [H]

Identifier: 238920456

GI number: 238920456

Start: 2459500

End: 2460579

Strand: Direct

Name: hisB [H]

Synonym: NT01EI_2567

Alternate gene names: 238920456

Gene position: 2459500-2460579 (Clockwise)

Preceding gene: 238920455

Following gene: 238920457

Centisome position: 64.51

GC content: 62.78

Gene sequence:

>1080_bases
ATGAAGAAATATCTGTTTATCGATCGCGACGGCACCCTGATCGCCGAGCCGCCGCAGGACTTTCAGGTAGACCGTCTGGA
CAAGCTGGCGCTGATGCCCGGGGTCATTCCGGCGCTGCTGCGACTGCAGCAGGCCGGCTATCATCTGGTGATGGTCAGTA
ATCAGGATGGACTGGGCAGCGAACGCTTTCCGCAGGCCGACTTCGATGCGCCACACGCGCTCATGATGCAGATACTGACC
TCGCAGGGCATCCTGTTCGAGCGGGTGCTGATCTGTCCACATCTGCCGCAGGAGGGGTGCCGCTGCCGCAAACCCGCCAC
CGGGCTGCTCACCGACTATCTGCAGCCCGGCGTGCTGGATACGGCCAACGCGTGGGTGATCGGCGACCGCGACAGCGATC
TGCAGCTGGCGCACAACATGGGGATCAACGGACTGCGCTACGCCGCGACCCCAACCGATGGCGCCAGTCTGGACTGGCCG
CAGATTGCCGAACGCCTGACCCGCCGCGATCGCCATGCCCAGGTGGAGCGCGTCACCCGTGAGACCGCGCTGCTGGCGGA
AGTGTGGCTGGATCGTCAGGGCGAGAGCTACATCCGTACCGGTATCGGCTTTTTTGATCATATGCTGGATCAGATAGCCA
CCCACGCCGGCCTGCGCCTGCATATAGAGGCCAAGGGCGATCTGCATATCGATGATCATCACACCGTCGAAGATACCGCA
CTGGCGCTCGGCGAAGCCCTGCGCATCGCCCTGGGGGACAAGCGCGGCATCGCCCGCTTTGGCTTTGTCCTGCCGATGGA
CGAGTGTCTGGCCCGCTGTGCCCTGGATATCTCGGGCCGCCCCTACCTCTCCTTCAAGGCCGAATTCAGCCACCAGCGCG
TCGGGGATCTCAGCACCGAAATGGTCGGACACTTCTTCCACTCCCTCGCCTACGCGATGGGCGTTACCCTGCACCTGAAA
ACCAAGGGTAAGAACGACCACCACCGCGTAGAGAGCCTGTTCAAGGCCTTTGGCCGCACCCTGCGCCAGGCGATCCGCAT
CGAAGACGACCGCTTGCCCAGCTCAAAAGGAGTATTGTGA

Upstream 100 bases:

>100_bases
CTCGCTGGCCGACTGCCTGCGCATCACCATCGGCAGCACCGTGGAGCATGAGCGGGTTCTTGCGGTACTGCGCCATTTTA
GCCAGGAAGGAGAGGCGTAA

Downstream 100 bases:

>100_bases
TGGCCACAGCGTGCAACGTGGTGATTCTGGATACCGGCTGCGCCAACCTGGCCTCGGTGCGCTATGCCCTGGAGCGCCTG
GGCTGCCGGCCGACCGTCAG

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKKYLFIDRDGTLIAEPPQDFQVDRLDKLALMPGVIPALLRLQQAGYHLVMVSNQDGLGSERFPQADFDAPHALMMQILT
SQGILFERVLICPHLPQEGCRCRKPATGLLTDYLQPGVLDTANAWVIGDRDSDLQLAHNMGINGLRYAATPTDGASLDWP
QIAERLTRRDRHAQVERVTRETALLAEVWLDRQGESYIRTGIGFFDHMLDQIATHAGLRLHIEAKGDLHIDDHHTVEDTA
LALGEALRIALGDKRGIARFGFVLPMDECLARCALDISGRPYLSFKAEFSHQRVGDLSTEMVGHFFHSLAYAMGVTLHLK
TKGKNDHHRVESLFKAFGRTLRQAIRIEDDRLPSSKGVL

Sequences:

>Translated_359_residues
MKKYLFIDRDGTLIAEPPQDFQVDRLDKLALMPGVIPALLRLQQAGYHLVMVSNQDGLGSERFPQADFDAPHALMMQILT
SQGILFERVLICPHLPQEGCRCRKPATGLLTDYLQPGVLDTANAWVIGDRDSDLQLAHNMGINGLRYAATPTDGASLDWP
QIAERLTRRDRHAQVERVTRETALLAEVWLDRQGESYIRTGIGFFDHMLDQIATHAGLRLHIEAKGDLHIDDHHTVEDTA
LALGEALRIALGDKRGIARFGFVLPMDECLARCALDISGRPYLSFKAEFSHQRVGDLSTEMVGHFFHSLAYAMGVTLHLK
TKGKNDHHRVESLFKAFGRTLRQAIRIEDDRLPSSKGVL
>Mature_359_residues
MKKYLFIDRDGTLIAEPPQDFQVDRLDKLALMPGVIPALLRLQQAGYHLVMVSNQDGLGSERFPQADFDAPHALMMQILT
SQGILFERVLICPHLPQEGCRCRKPATGLLTDYLQPGVLDTANAWVIGDRDSDLQLAHNMGINGLRYAATPTDGASLDWP
QIAERLTRRDRHAQVERVTRETALLAEVWLDRQGESYIRTGIGFFDHMLDQIATHAGLRLHIEAKGDLHIDDHHTVEDTA
LALGEALRIALGDKRGIARFGFVLPMDECLARCALDISGRPYLSFKAEFSHQRVGDLSTEMVGHFFHSLAYAMGVTLHLK
TKGKNDHHRVESLFKAFGRTLRQAIRIEDDRLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=358, Percent_Identity=73.463687150838, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786399, Length=170, Percent_Identity=31.7647058823529, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=49.6969696969697, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40200; Mature: 40200

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYLFIDRDGTLIAEPPQDFQVDRLDKLALMPGVIPALLRLQQAGYHLVMVSNQDGLGS
CCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
ERFPQADFDAPHALMMQILTSQGILFERVLICPHLPQEGCRCRKPATGLLTDYLQPGVLD
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
TANAWVIGDRDSDLQLAHNMGINGLRYAATPTDGASLDWPQIAERLTRRDRHAQVERVTR
CCCEEEECCCCCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ETALLAEVWLDRQGESYIRTGIGFFDHMLDQIATHAGLRLHIEAKGDLHIDDHHTVEDTA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHHHHH
LALGEALRIALGDKRGIARFGFVLPMDECLARCALDISGRPYLSFKAEFSHQRVGDLSTE
HHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
MVGHFFHSLAYAMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRIEDDRLPSSKGVL
HHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKKYLFIDRDGTLIAEPPQDFQVDRLDKLALMPGVIPALLRLQQAGYHLVMVSNQDGLGS
CCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
ERFPQADFDAPHALMMQILTSQGILFERVLICPHLPQEGCRCRKPATGLLTDYLQPGVLD
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
TANAWVIGDRDSDLQLAHNMGINGLRYAATPTDGASLDWPQIAERLTRRDRHAQVERVTR
CCCEEEECCCCCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ETALLAEVWLDRQGESYIRTGIGFFDHMLDQIATHAGLRLHIEAKGDLHIDDHHTVEDTA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHHHHH
LALGEALRIALGDKRGIARFGFVLPMDECLARCALDISGRPYLSFKAEFSHQRVGDLSTE
HHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
MVGHFFHSLAYAMGVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRIEDDRLPSSKGVL
HHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]