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The map label for this gene is hemN [H]

Identifier: 238919809

GI number: 238919809

Start: 1841116

End: 1842498

Strand: Reverse

Name: hemN [H]

Synonym: NT01EI_1913

Alternate gene names: 238919809

Gene position: 1842498-1841116 (Counterclockwise)

Preceding gene: 238919810

Following gene: 238919808

Centisome position: 48.33

GC content: 64.43

Gene sequence:

>1383_bases
ATGACGCTGGACATTACCCCTTATCTGGCCGCGGCCGAGGGCATCCCCTTTCCCGAACGCTGGGCCACCATGCCCTGGCG
CCATCAGCAGCCCCTGCCTGCCGACGCCCTGACACAGGGCTGGCAACAGCTGTGCCAACGCACCCTGCCGCCCAATAAGC
GCCTGGTCTATGTGCATATTCCCTTTTGCGCCACCCACTGTACCTTCTGTGGCTTTTATCAAAACCGCTTCAGCGAGCAG
GCCATTGCCCGCTACTTCGACTACCTGCAGCGCGAAATCGACCTGGAGAGTGCCCTGCCGCTGCAGCAATCGGCACCCAT
TCACGCCATCTATCTGGGCGGCGGTACCCCCAGTGCCCTAAACGCTGAACAGCTGCACCGCCTCATTGTTCAACTGCGTA
GCCTCCTCCCGCTGGCCGCCGACTGCGAAATCACCGTCGAAGGACGCGTTCTGAACTTTGATGATGCGCGCATTGACGCC
TGCCTGGCGGCCGGTGCCAACCGTTTTTCCATCGGCATCCAGACCTTTGATACCCATCTGCGTCAGCGCATGGGGCGGCG
AGCCGATCGCGATCGGGCCATCGCCTTTCTGCGGGCATTGGCCGAGCGCGACCGGGCGGCGGTGATCTGCGATCTGATGT
TTGGCCTGCCGGGACAGACCGCGCGGGAGTGGCAAAACGACCTGGACATCGTCCACGATTTGCCGCTGGACGGCGTCGAT
CTCTACGCCCTCAACCTGCTACCCTCAACGCCGCTGGCCAGGGCCGTCGACAGCGCCCGCACCCGCGTCGCCGACGCCGC
CGAGCGCCAGTCATTCTACCTGCATGCATTCGATGAGCTGGATAAGCGGGGCTGGCACCAGCTCAGCAACAGCCACTGGG
CACGCACCACCCGCGAGCGCAACCTGTATAACCTGCTGATCAAGCAGGGTGCCGACTGCCTGGCCTTCGGCAGCGGTGCC
GGTGGCCACCTTGATGGCCAGTCCTATATGCTGCAGCGTTCCCTGGAGGCCTACTATCAACGGCTGGACGCCGCGGATAA
GCCGCTGATGATGCTGAGCGCACCCGCGCCGCAGCACCGCTGGCGCCTGACGCTGCAGGGCGGCATCGAGACCGGGCGGC
TGGCTCTCGCCACCCTGCCCGGCGATCCTGCGCCGCTGCTGCCACTGCTCCAACAGTGGCAATCCTGCAACTTGCTACGC
CTGCAGGATCACTGCCTCATGCTGACGCCACGCGGACGTTTTTGGGCCAGCAATCTGCTGCAGGCCCTACAGCAGCTGTT
GGCCCAGTTGTTAACCCCGACAGCGATGACATCCCCTGTTGCGGGCGCCCGCGCCGCACACGCCCCCCAACACACACCCC
CGGAGAGACACCATGCATCCTAA

Upstream 100 bases:

>100_bases
TCTGCTTGATCCAGATCATAAACAATTCGCATCCCCGTTGATCGAATGATAATTATTATCATTAAATGCCGCGCATTTCA
GGTATTAACGGAGAGTTACC

Downstream 100 bases:

>100_bases
AAACCTGTCACGCGTTGCCGAACTGGACGCCTTTCTATCCACGGCGCCGATGGATACCGTTGAAGAGATAGCCCAACGCT
TCGCGCTTTCTGCGCTGGAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTLDITPYLAAAEGIPFPERWATMPWRHQQPLPADALTQGWQQLCQRTLPPNKRLVYVHIPFCATHCTFCGFYQNRFSEQ
AIARYFDYLQREIDLESALPLQQSAPIHAIYLGGGTPSALNAEQLHRLIVQLRSLLPLAADCEITVEGRVLNFDDARIDA
CLAAGANRFSIGIQTFDTHLRQRMGRRADRDRAIAFLRALAERDRAAVICDLMFGLPGQTAREWQNDLDIVHDLPLDGVD
LYALNLLPSTPLARAVDSARTRVADAAERQSFYLHAFDELDKRGWHQLSNSHWARTTRERNLYNLLIKQGADCLAFGSGA
GGHLDGQSYMLQRSLEAYYQRLDAADKPLMMLSAPAPQHRWRLTLQGGIETGRLALATLPGDPAPLLPLLQQWQSCNLLR
LQDHCLMLTPRGRFWASNLLQALQQLLAQLLTPTAMTSPVAGARAAHAPQHTPPERHHAS

Sequences:

>Translated_460_residues
MTLDITPYLAAAEGIPFPERWATMPWRHQQPLPADALTQGWQQLCQRTLPPNKRLVYVHIPFCATHCTFCGFYQNRFSEQ
AIARYFDYLQREIDLESALPLQQSAPIHAIYLGGGTPSALNAEQLHRLIVQLRSLLPLAADCEITVEGRVLNFDDARIDA
CLAAGANRFSIGIQTFDTHLRQRMGRRADRDRAIAFLRALAERDRAAVICDLMFGLPGQTAREWQNDLDIVHDLPLDGVD
LYALNLLPSTPLARAVDSARTRVADAAERQSFYLHAFDELDKRGWHQLSNSHWARTTRERNLYNLLIKQGADCLAFGSGA
GGHLDGQSYMLQRSLEAYYQRLDAADKPLMMLSAPAPQHRWRLTLQGGIETGRLALATLPGDPAPLLPLLQQWQSCNLLR
LQDHCLMLTPRGRFWASNLLQALQQLLAQLLTPTAMTSPVAGARAAHAPQHTPPERHHAS
>Mature_459_residues
TLDITPYLAAAEGIPFPERWATMPWRHQQPLPADALTQGWQQLCQRTLPPNKRLVYVHIPFCATHCTFCGFYQNRFSEQA
IARYFDYLQREIDLESALPLQQSAPIHAIYLGGGTPSALNAEQLHRLIVQLRSLLPLAADCEITVEGRVLNFDDARIDAC
LAAGANRFSIGIQTFDTHLRQRMGRRADRDRAIAFLRALAERDRAAVICDLMFGLPGQTAREWQNDLDIVHDLPLDGVDL
YALNLLPSTPLARAVDSARTRVADAAERQSFYLHAFDELDKRGWHQLSNSHWARTTRERNLYNLLIKQGADCLAFGSGAG
GHLDGQSYMLQRSLEAYYQRLDAADKPLMMLSAPAPQHRWRLTLQGGIETGRLALATLPGDPAPLLPLLQQWQSCNLLRL
QDHCLMLTPRGRFWASNLLQALQQLLAQLLTPTAMTSPVAGARAAHAPQHTPPERHHAS

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=28.7272727272727, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082341, Length=311, Percent_Identity=27.6527331189711, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789325, Length=334, Percent_Identity=29.6407185628743, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51559; Mature: 51427

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDITPYLAAAEGIPFPERWATMPWRHQQPLPADALTQGWQQLCQRTLPPNKRLVYVHI
CCEECCCHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
PFCATHCTFCGFYQNRFSEQAIARYFDYLQREIDLESALPLQQSAPIHAIYLGGGTPSAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEEEEEECCCCCCCC
NAEQLHRLIVQLRSLLPLAADCEITVEGRVLNFDDARIDACLAAGANRFSIGIQTFDTHL
CHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCHHHHHHHHHCCCCEEEEEHHHHHHHH
RQRMGRRADRDRAIAFLRALAERDRAAVICDLMFGLPGQTAREWQNDLDIVHDLPLDGVD
HHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
LYALNLLPSTPLARAVDSARTRVADAAERQSFYLHAFDELDKRGWHQLSNSHWARTTRER
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHH
NLYNLLIKQGADCLAFGSGAGGHLDGQSYMLQRSLEAYYQRLDAADKPLMMLSAPAPQHR
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCE
WRLTLQGGIETGRLALATLPGDPAPLLPLLQQWQSCNLLRLQDHCLMLTPRGRFWASNLL
EEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCEEEECCCCCHHHHHHH
QALQQLLAQLLTPTAMTSPVAGARAAHAPQHTPPERHHAS
HHHHHHHHHHHCCHHHCCCCCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLDITPYLAAAEGIPFPERWATMPWRHQQPLPADALTQGWQQLCQRTLPPNKRLVYVHI
CEECCCHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
PFCATHCTFCGFYQNRFSEQAIARYFDYLQREIDLESALPLQQSAPIHAIYLGGGTPSAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCEEEEEECCCCCCCC
NAEQLHRLIVQLRSLLPLAADCEITVEGRVLNFDDARIDACLAAGANRFSIGIQTFDTHL
CHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCHHHHHHHHHCCCCEEEEEHHHHHHHH
RQRMGRRADRDRAIAFLRALAERDRAAVICDLMFGLPGQTAREWQNDLDIVHDLPLDGVD
HHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
LYALNLLPSTPLARAVDSARTRVADAAERQSFYLHAFDELDKRGWHQLSNSHWARTTRER
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCHHHHHHHHH
NLYNLLIKQGADCLAFGSGAGGHLDGQSYMLQRSLEAYYQRLDAADKPLMMLSAPAPQHR
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCE
WRLTLQGGIETGRLALATLPGDPAPLLPLLQQWQSCNLLRLQDHCLMLTPRGRFWASNLL
EEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCEEEECCCCCHHHHHHH
QALQQLLAQLLTPTAMTSPVAGARAAHAPQHTPPERHHAS
HHHHHHHHHHHCCHHHCCCCCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]