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The map label for this gene is dxs [C]

Identifier: 238919277

GI number: 238919277

Start: 1356215

End: 1357159

Strand: Direct

Name: dxs [C]

Synonym: NT01EI_1367

Alternate gene names: 238919277

Gene position: 1356215-1357159 (Clockwise)

Preceding gene: 238919276

Following gene: 238919278

Centisome position: 35.57

GC content: 65.93

Gene sequence:

>945_bases
ATGAATAAGGTTCCGCCGCGTGACGGCTATGGTAACGCCCTGCTGTATCTGGCAGAGCACGATGACAGGCTGGTGGCGCT
GGATGCCGACGTGGCGAAGTCCACGCGCAGCAACTGGCTGGCGGCCCGCTATCCCGAACGCTTTATCAATATGGGGATCT
CCGAACAGGACATGGTGGGGACGGCAGCGGGGCTGGCGTTGAGCGGTATGCTGCCCTTTGCCGCCACCTATGCGGTGTTT
CTCAGCGGGCGCGCCTTCGATCAGATCCGCACGACGGTGTGCTACGGCGATCTGAACGTCAAGCTGGCCGGTGCCCACGC
CGGGATCTCGGTCGGCCCGGACGGTGCGACCCATCAGGCGCTGGAAGATGTGGCGCTGATGCGTACGCTGCCCAATATGA
CCGTGGTCGTACCCTGCGACGCGCTGGAGACCGAAAAGGCCACGCTGGCGCTGGCAGAGCATCCCGGTCCCGCCTATATC
CGCTTTGGCCGCGAGGCGACGCCACTGATAACCGGGCCGGAGACCCCCTTTACACTGGGCAAGGCGCGTCTGGTCAGCGA
TGGCACGGATTTGGTGATTTTTGCCAACGGGGCGCTGGTGTATCAGGCGATGCTGGCGGCCCAGGTGCTGGCGGACCGGC
AGATTTCGGCGATGGTGGTGGATCTGCATACGGTGAAACCGCTGGATGTCGGGTTCATCTGTGCCGCGGCGCAGGCGACG
CGGGCGGTGGTCACCGCAGAGGAGCACCAGAGAAACGGCGGCATGGGCAGCGCGGTGTGCGAGGCGCTGGCGCAGCGCTG
TCCCTGCCCGGTGATCCGGGTGGGGGTGGACGACAGCTTTGGCGAGAGCGGTGAGCCGGAGGCGCTGATGGCCCGCTATG
GGCTGGATGCCGCACATATCGTCGCCGCCGCCCAGCGGGCGCTGGCACTCAAGGGCGGCCAATAA

Upstream 100 bases:

>100_bases
CACCAGGCCAACTGGCACGGTCAGGCGCCGGATGCGGCGCAGCTGGCTCAGGCTCTGGATGAGATCCAGGCATATCAGGA
ACGGGATCCGGGAGGCCGCG

Downstream 100 bases:

>100_bases
AAGGAGAAGTGGTAATGACAGAGCAGACCCGCGTAAATATTGTGGAGATCGGCCCGCGTGACGGGTTCCAAAACGTGCGC
GATTTTATTCCCACTGCGCT

Product: transketolase, pyridine binding domain

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNKVPPRDGYGNALLYLAEHDDRLVALDADVAKSTRSNWLAARYPERFINMGISEQDMVGTAAGLALSGMLPFAATYAVF
LSGRAFDQIRTTVCYGDLNVKLAGAHAGISVGPDGATHQALEDVALMRTLPNMTVVVPCDALETEKATLALAEHPGPAYI
RFGREATPLITGPETPFTLGKARLVSDGTDLVIFANGALVYQAMLAAQVLADRQISAMVVDLHTVKPLDVGFICAAAQAT
RAVVTAEEHQRNGGMGSAVCEALAQRCPCPVIRVGVDDSFGESGEPEALMARYGLDAAHIVAAAQRALALKGGQ

Sequences:

>Translated_314_residues
MNKVPPRDGYGNALLYLAEHDDRLVALDADVAKSTRSNWLAARYPERFINMGISEQDMVGTAAGLALSGMLPFAATYAVF
LSGRAFDQIRTTVCYGDLNVKLAGAHAGISVGPDGATHQALEDVALMRTLPNMTVVVPCDALETEKATLALAEHPGPAYI
RFGREATPLITGPETPFTLGKARLVSDGTDLVIFANGALVYQAMLAAQVLADRQISAMVVDLHTVKPLDVGFICAAAQAT
RAVVTAEEHQRNGGMGSAVCEALAQRCPCPVIRVGVDDSFGESGEPEALMARYGLDAAHIVAAAQRALALKGGQ
>Mature_314_residues
MNKVPPRDGYGNALLYLAEHDDRLVALDADVAKSTRSNWLAARYPERFINMGISEQDMVGTAAGLALSGMLPFAATYAVF
LSGRAFDQIRTTVCYGDLNVKLAGAHAGISVGPDGATHQALEDVALMRTLPNMTVVVPCDALETEKATLALAEHPGPAYI
RFGREATPLITGPETPFTLGKARLVSDGTDLVIFANGALVYQAMLAAQVLADRQISAMVVDLHTVKPLDVGFICAAAQAT
RAVVTAEEHQRNGGMGSAVCEALAQRCPCPVIRVGVDDSFGESGEPEALMARYGLDAAHIVAAAQRALALKGGQ

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637461, Length=310, Percent_Identity=39.3548387096774, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI225637463, Length=310, Percent_Identity=39.3548387096774, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI225637459, Length=310, Percent_Identity=39.3548387096774, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI205277463, Length=314, Percent_Identity=36.624203821656, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4507521, Length=314, Percent_Identity=36.624203821656, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI133778974, Length=310, Percent_Identity=35.4838709677419, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI156564403, Length=281, Percent_Identity=23.8434163701068, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786622, Length=309, Percent_Identity=35.5987055016181, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788808, Length=302, Percent_Identity=25.8278145695364, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994911, Length=318, Percent_Identity=24.2138364779874, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539652, Length=312, Percent_Identity=39.7435897435897, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325331, Length=312, Percent_Identity=25.3205128205128, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319593, Length=224, Percent_Identity=27.2321428571429, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24645119, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24666278, Length=307, Percent_Identity=35.5048859934853, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21358145, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650940, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33047; Mature: 33047

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVPPRDGYGNALLYLAEHDDRLVALDADVAKSTRSNWLAARYPERFINMGISEQDMVG
CCCCCCCCCCCCEEEEEEECCCEEEEEECHHHHHHHCCCEEHHCCHHHHHCCCCCHHHHH
TAAGLALSGMLPFAATYAVFLSGRAFDQIRTTVCYGDLNVKLAGAHAGISVGPDGATHQA
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCEEEEECCCCCCEECCCCCHHHH
LEDVALMRTLPNMTVVVPCDALETEKATLALAEHPGPAYIRFGREATPLITGPETPFTLG
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCCCC
KARLVSDGTDLVIFANGALVYQAMLAAQVLADRQISAMVVDLHTVKPLDVGFICAAAQAT
CEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHEEHHHHHH
RAVVTAEEHQRNGGMGSAVCEALAQRCPCPVIRVGVDDSFGESGEPEALMARYGLDAAHI
HEEEEHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHCCCHHHH
VAAAQRALALKGGQ
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNKVPPRDGYGNALLYLAEHDDRLVALDADVAKSTRSNWLAARYPERFINMGISEQDMVG
CCCCCCCCCCCCEEEEEEECCCEEEEEECHHHHHHHCCCEEHHCCHHHHHCCCCCHHHHH
TAAGLALSGMLPFAATYAVFLSGRAFDQIRTTVCYGDLNVKLAGAHAGISVGPDGATHQA
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHEEEEEEECCEEEEECCCCCCEECCCCCHHHH
LEDVALMRTLPNMTVVVPCDALETEKATLALAEHPGPAYIRFGREATPLITGPETPFTLG
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCCCC
KARLVSDGTDLVIFANGALVYQAMLAAQVLADRQISAMVVDLHTVKPLDVGFICAAAQAT
CEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHEEHHHHHH
RAVVTAEEHQRNGGMGSAVCEALAQRCPCPVIRVGVDDSFGESGEPEALMARYGLDAAHI
HEEEEHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHCCCHHHH
VAAAQRALALKGGQ
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]