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The map label for this gene is recQ [H]

Identifier: 238917622

GI number: 238917622

Start: 1764920

End: 1766575

Strand: Reverse

Name: recQ [H]

Synonym: EUBELI_01701

Alternate gene names: 238917622

Gene position: 1766575-1764920 (Counterclockwise)

Preceding gene: 238917623

Following gene: 238917621

Centisome position: 82.39

GC content: 39.55

Gene sequence:

>1656_bases
ATGGATAAATACGGAATATTAAAGCATTATTTTGGGTATGATTCATTTCGTCCAGGTCAGGAAAAGTTAGTTGATGCTAT
TCTTGCTGGGCAGGATGTGTTAGGAATTATGCCTACAGGTGCGGGAAAATCATTATGTTATCAGGTGCCGGCATTGTTAA
TGTCCGGCATTACTCTTGTTGTATCTCCACTTATATCGCTAATGAAGGATCAGGTTGGAGCACTTAATCAGGCAGGTGTA
CATGCAGCTTATATTAACAGTTCTCTTACAGATAATCAGATAACTAAGGCACTCGCATATGCAAAGCAGGGACGGTATAA
AATTATATATGTTGCACCTGAAAGGCTGGAAACCTGGGGATTTCTTGATTTTGCCACGCATGTAGAGATATCTATGATTA
CTGTAGATGAAGCTCACTGTATATCACAGTGGGGGCAGGATTTCAGACCAAGTTATCTGAATATATTGTCATTTGTTAAG
AAGCTGGCAAGGCGTCCTATAATAAGCGCATTTACAGCTACAGCGACAAGCAAAGTAAGAGATGATATATTGCAGATTCT
TTCCCTCGAAAGACCGGTAATACTCACTACAGGTTTTGACAGAAGCAATCTGACATTCAAGGTCAAGCATATTAAGGACA
AGGATTCATATATACTTGATTACCTTGTAAGCCACAGACAGGATAGTGGAATTATATACTGTGCTACAAGAAAAAATGTT
GAAAAAGTCTATGACATGCTTAATGCCAACGGACTTTCTGTGACTAAGTATCATGCAGGTCTCTCAGCAGAAGAGAGAAA
AGAAAATCAGGATTCATTTATATATGATATCAAGCCGGTTGTTGTTGCAACTAATGCATTTGGAATGGGAATTGACAAGT
CAAATGTAAGATTTGTAATTCATTATAATATGCCGCAGTGTATAGAGAATTATTATCAGGAGGCTGGACGTGCCGGAAGA
GATGGAGAGGATTCAGAATGCGTATTGCTGTATTCTCCGCAGGATATCATGATAAATAAGTTTTTCATAGAACACAGAGA
GCCTAATCCTGATATTGATGCAGAAGAACAGGCACGGCTTATGATTCTTGATAAAAGAAGGCTTAATGCAATGGTCGATT
ACTGCAAGACAACAGGTTGTTTAAGAGAGTATATACTTAAATATTTTGGAGAAAGACCAGACAATCCAGAGGGTGGAAGA
TATAACTGCCATAACTGCTCTAATTGTGTCGTTGATGAGGCAGAGCAGGAAGCAGATGAGGCTTATATGTATCCGGGAAA
CCGTTTCAGTGCACCTGTATCAAGGAATGCTGCAATGGTGGCAGACAGAATGAAGCGTTCTGCTGCTGCTGCAAAATCAG
CATATGCAACATCTAAGTCAAAGAAGCCGGAGGATGCACTTAATGACAGAGGTGTTATGTTGTTTAACAGACTGCGTGAG
TTAAGAAAACAGATAGCTGTTTCAGTAGGCGTTCCGCCATATGTAATATTTTCAGACAGGACGCTTATAGATATGTGTCT
TAAAGTTCCGTTTAATCAGGAAGAAATGCTGTCAGTAAGCGGTGTCGGTGAGAATAAATATGAGCGCTATGGCAAGGTGT
TTATGGATGAAATATATGATTTTCTCGATGGTATGAAGCAGAATCTGGCAAGATGA

Upstream 100 bases:

>100_bases
CGAATATGATATAAAGACAGATAAGAACTTTGAAGATACGAGAAGCAGAGCTGATAAGAAAATGTATGAGAGTAAGAGAA
GATTGAAAAGAGAGTGATAT

Downstream 100 bases:

>100_bases
GAAAATGTGCTTATGGACAGTATTTTGCGAGATGAGATTACAGATGTTAATTGTATGAAATTATATGGCTTCAAATCAGA
AGAATGAATGGGAGATATGA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MDKYGILKHYFGYDSFRPGQEKLVDAILAGQDVLGIMPTGAGKSLCYQVPALLMSGITLVVSPLISLMKDQVGALNQAGV
HAAYINSSLTDNQITKALAYAKQGRYKIIYVAPERLETWGFLDFATHVEISMITVDEAHCISQWGQDFRPSYLNILSFVK
KLARRPIISAFTATATSKVRDDILQILSLERPVILTTGFDRSNLTFKVKHIKDKDSYILDYLVSHRQDSGIIYCATRKNV
EKVYDMLNANGLSVTKYHAGLSAEERKENQDSFIYDIKPVVVATNAFGMGIDKSNVRFVIHYNMPQCIENYYQEAGRAGR
DGEDSECVLLYSPQDIMINKFFIEHREPNPDIDAEEQARLMILDKRRLNAMVDYCKTTGCLREYILKYFGERPDNPEGGR
YNCHNCSNCVVDEAEQEADEAYMYPGNRFSAPVSRNAAMVADRMKRSAAAAKSAYATSKSKKPEDALNDRGVMLFNRLRE
LRKQIAVSVGVPPYVIFSDRTLIDMCLKVPFNQEEMLSVSGVGENKYERYGKVFMDEIYDFLDGMKQNLAR

Sequences:

>Translated_551_residues
MDKYGILKHYFGYDSFRPGQEKLVDAILAGQDVLGIMPTGAGKSLCYQVPALLMSGITLVVSPLISLMKDQVGALNQAGV
HAAYINSSLTDNQITKALAYAKQGRYKIIYVAPERLETWGFLDFATHVEISMITVDEAHCISQWGQDFRPSYLNILSFVK
KLARRPIISAFTATATSKVRDDILQILSLERPVILTTGFDRSNLTFKVKHIKDKDSYILDYLVSHRQDSGIIYCATRKNV
EKVYDMLNANGLSVTKYHAGLSAEERKENQDSFIYDIKPVVVATNAFGMGIDKSNVRFVIHYNMPQCIENYYQEAGRAGR
DGEDSECVLLYSPQDIMINKFFIEHREPNPDIDAEEQARLMILDKRRLNAMVDYCKTTGCLREYILKYFGERPDNPEGGR
YNCHNCSNCVVDEAEQEADEAYMYPGNRFSAPVSRNAAMVADRMKRSAAAAKSAYATSKSKKPEDALNDRGVMLFNRLRE
LRKQIAVSVGVPPYVIFSDRTLIDMCLKVPFNQEEMLSVSGVGENKYERYGKVFMDEIYDFLDGMKQNLAR
>Mature_551_residues
MDKYGILKHYFGYDSFRPGQEKLVDAILAGQDVLGIMPTGAGKSLCYQVPALLMSGITLVVSPLISLMKDQVGALNQAGV
HAAYINSSLTDNQITKALAYAKQGRYKIIYVAPERLETWGFLDFATHVEISMITVDEAHCISQWGQDFRPSYLNILSFVK
KLARRPIISAFTATATSKVRDDILQILSLERPVILTTGFDRSNLTFKVKHIKDKDSYILDYLVSHRQDSGIIYCATRKNV
EKVYDMLNANGLSVTKYHAGLSAEERKENQDSFIYDIKPVVVATNAFGMGIDKSNVRFVIHYNMPQCIENYYQEAGRAGR
DGEDSECVLLYSPQDIMINKFFIEHREPNPDIDAEEQARLMILDKRRLNAMVDYCKTTGCLREYILKYFGERPDNPEGGR
YNCHNCSNCVVDEAEQEADEAYMYPGNRFSAPVSRNAAMVADRMKRSAAAAKSAYATSKSKKPEDALNDRGVMLFNRLRE
LRKQIAVSVGVPPYVIFSDRTLIDMCLKVPFNQEEMLSVSGVGENKYERYGKVFMDEIYDFLDGMKQNLAR

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI148612816, Length=429, Percent_Identity=40.3263403263403, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI169218196, Length=417, Percent_Identity=39.568345323741, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI110735439, Length=417, Percent_Identity=39.568345323741, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI4557365, Length=417, Percent_Identity=39.568345323741, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI51242947, Length=398, Percent_Identity=40.7035175879397, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI51242943, Length=398, Percent_Identity=40.7035175879397, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI14591902, Length=419, Percent_Identity=36.9928400954654, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI14591904, Length=419, Percent_Identity=36.9928400954654, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI284005309, Length=347, Percent_Identity=38.6167146974063, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI20149629, Length=339, Percent_Identity=26.2536873156342, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI13514831, Length=401, Percent_Identity=23.6907730673317, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21071032, Length=331, Percent_Identity=24.1691842900302, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI87196351, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI301171475, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI301171467, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI169881239, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI13514809, Length=150, Percent_Identity=31.3333333333333, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI222352149, Length=359, Percent_Identity=24.5125348189415, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI31542656, Length=358, Percent_Identity=25.4189944134078, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38327634, Length=368, Percent_Identity=22.0108695652174, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994977, Length=405, Percent_Identity=43.2098765432099, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI87082221, Length=350, Percent_Identity=23.1428571428571, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787605, Length=344, Percent_Identity=24.1279069767442, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564293, Length=414, Percent_Identity=39.3719806763285, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI25145561, Length=432, Percent_Identity=37.962962962963, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71987997, Length=417, Percent_Identity=36.9304556354916, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71987993, Length=417, Percent_Identity=36.9304556354916, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17552866, Length=420, Percent_Identity=37.3809523809524, Blast_Score=241, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17555296, Length=337, Percent_Identity=27.0029673590504, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17507945, Length=325, Percent_Identity=23.3846153846154, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71995718, Length=356, Percent_Identity=25.8426966292135, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537549, Length=340, Percent_Identity=22.3529411764706, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532548, Length=328, Percent_Identity=21.9512195121951, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532546, Length=328, Percent_Identity=21.9512195121951, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86570094, Length=334, Percent_Identity=23.0538922155689, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=416, Percent_Identity=38.9423076923077, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6324217, Length=361, Percent_Identity=24.6537396121884, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321360, Length=336, Percent_Identity=24.702380952381, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321856, Length=348, Percent_Identity=25.5747126436782, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320224, Length=365, Percent_Identity=22.1917808219178, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323021, Length=370, Percent_Identity=23.7837837837838, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325138, Length=149, Percent_Identity=26.1744966442953, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320041, Length=319, Percent_Identity=22.257053291536, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324778, Length=149, Percent_Identity=26.8456375838926, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646066, Length=429, Percent_Identity=37.995337995338, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24664226, Length=419, Percent_Identity=35.3221957040573, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI62472181, Length=419, Percent_Identity=35.3221957040573, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24664230, Length=419, Percent_Identity=35.3221957040573, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI21358123, Length=356, Percent_Identity=37.3595505617978, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17977678, Length=371, Percent_Identity=25.8760107816712, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585582, Length=353, Percent_Identity=27.1954674220963, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355075, Length=364, Percent_Identity=23.9010989010989, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17985987, Length=345, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574962, Length=333, Percent_Identity=21.9219219219219, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666101, Length=347, Percent_Identity=24.4956772334294, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24662330, Length=347, Percent_Identity=23.6311239193084, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 62288; Mature: 62288

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKYGILKHYFGYDSFRPGQEKLVDAILAGQDVLGIMPTGAGKSLCYQVPALLMSGITLV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
VSPLISLMKDQVGALNQAGVHAAYINSSLTDNQITKALAYAKQGRYKIIYVAPERLETWG
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHCC
FLDFATHVEISMITVDEAHCISQWGQDFRPSYLNILSFVKKLARRPIISAFTATATSKVR
EEEECCEEEEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DDILQILSLERPVILTTGFDRSNLTFKVKHIKDKDSYILDYLVSHRQDSGIIYCATRKNV
HHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCH
EKVYDMLNANGLSVTKYHAGLSAEERKENQDSFIYDIKPVVVATNAFGMGIDKSNVRFVI
HHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEE
HYNMPQCIENYYQEAGRAGRDGEDSECVLLYSPQDIMINKFFIEHREPNPDIDAEEQARL
EECCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEE
MILDKRRLNAMVDYCKTTGCLREYILKYFGERPDNPEGGRYNCHNCSNCVVDEAEQEADE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCHHHHHCCC
AYMYPGNRFSAPVSRNAAMVADRMKRSAAAAKSAYATSKSKKPEDALNDRGVMLFNRLRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHH
LRKQIAVSVGVPPYVIFSDRTLIDMCLKVPFNQEEMLSVSGVGENKYERYGKVFMDEIYD
HHHHHEEECCCCCEEEECCCHHHHHHHHCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHH
FLDGMKQNLAR
HHHHHHHHHCC
>Mature Secondary Structure
MDKYGILKHYFGYDSFRPGQEKLVDAILAGQDVLGIMPTGAGKSLCYQVPALLMSGITLV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
VSPLISLMKDQVGALNQAGVHAAYINSSLTDNQITKALAYAKQGRYKIIYVAPERLETWG
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHCC
FLDFATHVEISMITVDEAHCISQWGQDFRPSYLNILSFVKKLARRPIISAFTATATSKVR
EEEECCEEEEEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DDILQILSLERPVILTTGFDRSNLTFKVKHIKDKDSYILDYLVSHRQDSGIIYCATRKNV
HHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCH
EKVYDMLNANGLSVTKYHAGLSAEERKENQDSFIYDIKPVVVATNAFGMGIDKSNVRFVI
HHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEE
HYNMPQCIENYYQEAGRAGRDGEDSECVLLYSPQDIMINKFFIEHREPNPDIDAEEQARL
EECCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEE
MILDKRRLNAMVDYCKTTGCLREYILKYFGERPDNPEGGRYNCHNCSNCVVDEAEQEADE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCHHHHHCCC
AYMYPGNRFSAPVSRNAAMVADRMKRSAAAAKSAYATSKSKKPEDALNDRGVMLFNRLRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHH
LRKQIAVSVGVPPYVIFSDRTLIDMCLKVPFNQEEMLSVSGVGENKYERYGKVFMDEIYD
HHHHHEEECCCCCEEEECCCHHHHHHHHCCCCHHHHEEECCCCCHHHHHHHHHHHHHHHH
FLDGMKQNLAR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]