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The map label for this gene is cbh [H]

Identifier: 238917557

GI number: 238917557

Start: 1696546

End: 1697541

Strand: Direct

Name: cbh [H]

Synonym: EUBELI_01636

Alternate gene names: 238917557

Gene position: 1696546-1697541 (Clockwise)

Preceding gene: 238917539

Following gene: 238917560

Centisome position: 79.12

GC content: 39.46

Gene sequence:

>996_bases
ATGTGTACAGCAGCTACTTATAAAACTAAAGATTTCTATATGGGAAGAACACTAGATTATGAATTTTCTTATGGTGATGA
GGTGACTGTAACACCTAGAAATTATCCTATTAATTTCAGATTTATGGGTGTAAGGAATAACCACTTTGCGATGATTGGAA
TGGCACATGTGGCTGACGATTATCCTTTATATTATGAAGCATTTAACGAAAAAGGGCTTGGCATGGCCGGTCTTAACTTT
GTTGACAATGCAGCTTACAGCGAACCGGACCTAAGAGGTCTTAACGGAGAGAGTAATATTGAAAATGTTGCCGTATTCGA
ATTCATTCCGTGGATATTATCGCAGTGTGCGACAGTTGACGAAGCGAAAGAAAGACTGCAGTTTATTAATCTTACCAACA
CTCAGTTTAATGAAATGTTTCCATGTGCTAATCTTCACTGGATTATCGCTGACAAGGAAAGCTGCATAACTGTTGAATCC
ATGTCAGACGGACTTCATATATATGATAACCCTGTTGGCGTGCTTACTAATAATCCGCCATTTAACATACAGATGTTTAA
TCTTAACAATTACATGGGATTATCTGCAAAACAGCCTGAGAGCAATTTCTCGGACAGACTTGATTTCAACAGATACAGCC
GTGGTATGGGTGCACTCGGACTTCCTGGGGATCTGTCATCTCAGTCAAGATTCGTAAAGGTGGCTTTTACTAAGATGAAT
TCTGTTTCAGGTGACGATGAGAAATCAAGCGTAAGCCAGTTCTTTCATATATTAGGCAGCGTAGACCAGCAGCGTGGCTG
CTGTCAGCTAGACGATGACAAATACGAGATAACAATATATACCTGCTGCTGCAATACAACTAAAGGCATATATTATTACA
CATCATATGACAACCATCAGATATGTGCTGTTGATATGCATAAGGAGAACCTTGACGGTGATAAACTGGTTCGCTATCCA
CTTATTACTGATGGCGAGATAAGGGCTGTTAATTAA

Upstream 100 bases:

>100_bases
TAATTTATTTTGTCAGAATTGCCCGCAGAATATAATTGGTGTATTATTTTATAAAAAGATATCAGAATATTATTATAACT
TAAAAAATACAGGAGGGCTT

Downstream 100 bases:

>100_bases
TATATATACCTGACAAAACGAGCTGGACGTTTAATTACCATCCAGCTCGTTTTTAACACATTTTTCTATGTCGTACGCAA
TCTCAGTGCATATATCTTTT

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MCTAATYKTKDFYMGRTLDYEFSYGDEVTVTPRNYPINFRFMGVRNNHFAMIGMAHVADDYPLYYEAFNEKGLGMAGLNF
VDNAAYSEPDLRGLNGESNIENVAVFEFIPWILSQCATVDEAKERLQFINLTNTQFNEMFPCANLHWIIADKESCITVES
MSDGLHIYDNPVGVLTNNPPFNIQMFNLNNYMGLSAKQPESNFSDRLDFNRYSRGMGALGLPGDLSSQSRFVKVAFTKMN
SVSGDDEKSSVSQFFHILGSVDQQRGCCQLDDDKYEITIYTCCCNTTKGIYYYTSYDNHQICAVDMHKENLDGDKLVRYP
LITDGEIRAVN

Sequences:

>Translated_331_residues
MCTAATYKTKDFYMGRTLDYEFSYGDEVTVTPRNYPINFRFMGVRNNHFAMIGMAHVADDYPLYYEAFNEKGLGMAGLNF
VDNAAYSEPDLRGLNGESNIENVAVFEFIPWILSQCATVDEAKERLQFINLTNTQFNEMFPCANLHWIIADKESCITVES
MSDGLHIYDNPVGVLTNNPPFNIQMFNLNNYMGLSAKQPESNFSDRLDFNRYSRGMGALGLPGDLSSQSRFVKVAFTKMN
SVSGDDEKSSVSQFFHILGSVDQQRGCCQLDDDKYEITIYTCCCNTTKGIYYYTSYDNHQICAVDMHKENLDGDKLVRYP
LITDGEIRAVN
>Mature_331_residues
MCTAATYKTKDFYMGRTLDYEFSYGDEVTVTPRNYPINFRFMGVRNNHFAMIGMAHVADDYPLYYEAFNEKGLGMAGLNF
VDNAAYSEPDLRGLNGESNIENVAVFEFIPWILSQCATVDEAKERLQFINLTNTQFNEMFPCANLHWIIADKESCITVES
MSDGLHIYDNPVGVLTNNPPFNIQMFNLNNYMGLSAKQPESNFSDRLDFNRYSRGMGALGLPGDLSSQSRFVKVAFTKMN
SVSGDDEKSSVSQFFHILGSVDQQRGCCQLDDDKYEITIYTCCCNTTKGIYYYTSYDNHQICAVDMHKENLDGDKLVRYP
LITDGEIRAVN

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37577; Mature: 37577

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTAATYKTKDFYMGRTLDYEFSYGDEVTVTPRNYPINFRFMGVRNNHFAMIGMAHVADD
CCCCCEEECCEEECCEEEEEEECCCCEEEECCCCCCEEEEEEEECCCCEEEEEEEHHCCC
YPLYYEAFNEKGLGMAGLNFVDNAAYSEPDLRGLNGESNIENVAVFEFIPWILSQCATVD
CCEEEEECCCCCCCEECCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
EAKERLQFINLTNTQFNEMFPCANLHWIIADKESCITVESMSDGLHIYDNPVGVLTNNPP
HHHHHEEEEECCCCCHHHCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCEEEEECCCC
FNIQMFNLNNYMGLSAKQPESNFSDRLDFNRYSRGMGALGLPGDLSSQSRFVKVAFTKMN
CEEEEEECCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC
SVSGDDEKSSVSQFFHILGSVDQQRGCCQLDDDKYEITIYTCCCNTTKGIYYYTSYDNHQ
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCCCEEEEEECCCCE
ICAVDMHKENLDGDKLVRYPLITDGEIRAVN
EEEEECCCCCCCCCCEEEEECCCCCEEEEEC
>Mature Secondary Structure
MCTAATYKTKDFYMGRTLDYEFSYGDEVTVTPRNYPINFRFMGVRNNHFAMIGMAHVADD
CCCCCEEECCEEECCEEEEEEECCCCEEEECCCCCCEEEEEEEECCCCEEEEEEEHHCCC
YPLYYEAFNEKGLGMAGLNFVDNAAYSEPDLRGLNGESNIENVAVFEFIPWILSQCATVD
CCEEEEECCCCCCCEECCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
EAKERLQFINLTNTQFNEMFPCANLHWIIADKESCITVESMSDGLHIYDNPVGVLTNNPP
HHHHHEEEEECCCCCHHHCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCEEEEECCCC
FNIQMFNLNNYMGLSAKQPESNFSDRLDFNRYSRGMGALGLPGDLSSQSRFVKVAFTKMN
CEEEEEECCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC
SVSGDDEKSSVSQFFHILGSVDQQRGCCQLDDDKYEITIYTCCCNTTKGIYYYTSYDNHQ
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCCCEEEEEECCCCE
ICAVDMHKENLDGDKLVRYPLITDGEIRAVN
EEEEECCCCCCCCCCEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]