Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 238917560

GI number: 238917560

Start: 1699139

End: 1700644

Strand: Direct

Name: lon [H]

Synonym: EUBELI_01639

Alternate gene names: 238917560

Gene position: 1699139-1700644 (Clockwise)

Preceding gene: 238917557

Following gene: 238917570

Centisome position: 79.24

GC content: 39.18

Gene sequence:

>1506_bases
GTGTTTAAAGCACAGAAAGAGGAATATATGTTAGTTTATGACGCTAATGCCAATTCTGGCAGCAATGCCGGTTTTGAGTG
TACCTATACAACTTTTAAATCTGACAATTCTACAGCTTCACCAGAGAACCCAATCCTTGTTCTGGATAATTCTGAGAAAA
AGTGGGATGAGACATCTTATGGTTTATTCACTAACCCTTATAAAAAGACTGCATTTGATTTCCAGATTAACGGTGAATCT
TTTACAAGCAATATCTTAAAGATTGATTCAAGATTTACAAGCCTTATCAAATGGCTTGGTGAGAACAGAGTTAAAGTAAA
GCTTACAGGTGCTAACTCATCTGAAGGATATAATGTATACAAGATTCAGGAAGTTGCATTTGGCAATGGTAACAAGTTAT
CCGCTGAAGACGGTTTTCTTCAGTTTATGATTGAAAGATTATTAGAGAGCAGTGCCGTTGCAGAAGACAATAGTGAAGAG
CCTGATGAATCTGCTGATGATATGAAGCTTACAAGCCTTACAAGCATATCAGATTTTCTTAACTGTGCAGGAAGCACGCT
TCCTGAGAATATCCGTTTATGGGCAAGACGCAATCTTGTTGTTGCCCGTTCAAGCGAGGTAACTCCTGAGGAGAAAAGAC
ATGCACAGAGAGCACTTTCTATCATGCTTAATATTAAGTGGAAGAGCAATTACTTCGAATCAATTGACCCTGTGGAAGCA
AGAAGAATTCTTGACGAAGAGCTTTTTGGTATGGAAAGTGTTAAACAAAGAATAATTGAGACAGTTATTCAGATTAACAG
AACACACACTCTTCCTGCATATGGTATCCTTCTTGTTGGTCCTGCCGGAACAGGTAAATCACAGATTGCCTACCTTGTTG
CCAAGATTCTTAAAATGCCTTGGACAACTCTTGATATGAGTTCAATCAATGACGCAGAACAGCTTACAGGAAGTTCAAGA
ATATACTCCAATGCAAAGCCTGGTATTATCATGGAAGCATTCAACATGGCTGGTGAATCTAACCTTGTATTCATTATCAA
CGAGCTTGATAAGGCAACTTCAAGTAATGGTAACGCCAACCCTGCGGATGTACTCCTTACACTCCTTGATAATCTTGGAT
TCACTGATAATTACATGGAGTGTCTCATCCCAACTTCAGGCGTATATCCTATCGCCACAGCTAATGATAAGGATAAGATA
AGTGCACCGCTTCTTTCAAGATTTGCAGTAATTGATATTCCTGATTACACAAGAGAAGAGAAAAAGACAATTTTCCTTAA
ATATTCACTCCCAAAGGTTCTTAAAAGAATCGGACTTCACGAGGATGAGTGCCTGGTGTTTGATGACGGACTTGACGCTG
TTCTTGATTACTGCAAGGATACTACAGGTATCAGAGACCTTGAACAGGCAGCAGAACATTTAGCAGCACATGCTCTTTAT
ATGATCGAGGTTGAGCATGCCACAAGCGTTTCATACACAGCAGACATGGTAAATGAACTCTTTTAA

Upstream 100 bases:

>100_bases
TAATATTTTATCTATAATTATTATAGCACATAACTTAATATATTCAATCCTCTCCTTGCCAACTTCCCAGAATATGTTAT
TATATGATAGATTATTATAA

Downstream 100 bases:

>100_bases
TTAAATTATTCAAACCCGATAACAAATACATGATATACAATAAGGAGCTGATATCACTACGATAACAGCTCCTTAAATAA
TCTTTACATATGTAATTGTA

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MFKAQKEEYMLVYDANANSGSNAGFECTYTTFKSDNSTASPENPILVLDNSEKKWDETSYGLFTNPYKKTAFDFQINGES
FTSNILKIDSRFTSLIKWLGENRVKVKLTGANSSEGYNVYKIQEVAFGNGNKLSAEDGFLQFMIERLLESSAVAEDNSEE
PDESADDMKLTSLTSISDFLNCAGSTLPENIRLWARRNLVVARSSEVTPEEKRHAQRALSIMLNIKWKSNYFESIDPVEA
RRILDEELFGMESVKQRIIETVIQINRTHTLPAYGILLVGPAGTGKSQIAYLVAKILKMPWTTLDMSSINDAEQLTGSSR
IYSNAKPGIIMEAFNMAGESNLVFIINELDKATSSNGNANPADVLLTLLDNLGFTDNYMECLIPTSGVYPIATANDKDKI
SAPLLSRFAVIDIPDYTREEKKTIFLKYSLPKVLKRIGLHEDECLVFDDGLDAVLDYCKDTTGIRDLEQAAEHLAAHALY
MIEVEHATSVSYTADMVNELF

Sequences:

>Translated_501_residues
MFKAQKEEYMLVYDANANSGSNAGFECTYTTFKSDNSTASPENPILVLDNSEKKWDETSYGLFTNPYKKTAFDFQINGES
FTSNILKIDSRFTSLIKWLGENRVKVKLTGANSSEGYNVYKIQEVAFGNGNKLSAEDGFLQFMIERLLESSAVAEDNSEE
PDESADDMKLTSLTSISDFLNCAGSTLPENIRLWARRNLVVARSSEVTPEEKRHAQRALSIMLNIKWKSNYFESIDPVEA
RRILDEELFGMESVKQRIIETVIQINRTHTLPAYGILLVGPAGTGKSQIAYLVAKILKMPWTTLDMSSINDAEQLTGSSR
IYSNAKPGIIMEAFNMAGESNLVFIINELDKATSSNGNANPADVLLTLLDNLGFTDNYMECLIPTSGVYPIATANDKDKI
SAPLLSRFAVIDIPDYTREEKKTIFLKYSLPKVLKRIGLHEDECLVFDDGLDAVLDYCKDTTGIRDLEQAAEHLAAHALY
MIEVEHATSVSYTADMVNELF
>Mature_501_residues
MFKAQKEEYMLVYDANANSGSNAGFECTYTTFKSDNSTASPENPILVLDNSEKKWDETSYGLFTNPYKKTAFDFQINGES
FTSNILKIDSRFTSLIKWLGENRVKVKLTGANSSEGYNVYKIQEVAFGNGNKLSAEDGFLQFMIERLLESSAVAEDNSEE
PDESADDMKLTSLTSISDFLNCAGSTLPENIRLWARRNLVVARSSEVTPEEKRHAQRALSIMLNIKWKSNYFESIDPVEA
RRILDEELFGMESVKQRIIETVIQINRTHTLPAYGILLVGPAGTGKSQIAYLVAKILKMPWTTLDMSSINDAEQLTGSSR
IYSNAKPGIIMEAFNMAGESNLVFIINELDKATSSNGNANPADVLLTLLDNLGFTDNYMECLIPTSGVYPIATANDKDKI
SAPLLSRFAVIDIPDYTREEKKTIFLKYSLPKVLKRIGLHEDECLVFDDGLDAVLDYCKDTTGIRDLEQAAEHLAAHALY
MIEVEHATSVSYTADMVNELF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=281, Percent_Identity=29.5373665480427, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI31377667, Length=255, Percent_Identity=31.7647058823529, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1786643, Length=261, Percent_Identity=31.4176245210728, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17505831, Length=248, Percent_Identity=31.4516129032258, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17556486, Length=254, Percent_Identity=28.740157480315, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319449, Length=267, Percent_Identity=29.5880149812734, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24666867, Length=275, Percent_Identity=27.6363636363636, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI221513036, Length=275, Percent_Identity=27.6363636363636, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 55898; Mature: 55898

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKAQKEEYMLVYDANANSGSNAGFECTYTTFKSDNSTASPENPILVLDNSEKKWDETSY
CCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
GLFTNPYKKTAFDFQINGESFTSNILKIDSRFTSLIKWLGENRVKVKLTGANSSEGYNVY
CCEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEE
KIQEVAFGNGNKLSAEDGFLQFMIERLLESSAVAEDNSEEPDESADDMKLTSLTSISDFL
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHH
NCAGSTLPENIRLWARRNLVVARSSEVTPEEKRHAQRALSIMLNIKWKSNYFESIDPVEA
HHCCCCCCCHHEEEEECCEEEEECCCCCCHHHHHHHHHEEEEEEEEECCCCCCCCCHHHH
RRILDEELFGMESVKQRIIETVIQINRTHTLPAYGILLVGPAGTGKSQIAYLVAKILKMP
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
WTTLDMSSINDAEQLTGSSRIYSNAKPGIIMEAFNMAGESNLVFIINELDKATSSNGNAN
CCEEEHHCCCCHHHHCCCHHEECCCCCCEEEEHHHCCCCCCEEEEEECHHHHCCCCCCCC
PADVLLTLLDNLGFTDNYMECLIPTSGVYPIATANDKDKISAPLLSRFAVIDIPDYTREE
HHHHHHHHHHHCCCCCCHHHEEECCCCCEEEEECCCCHHHHHHHHHCEEEEECCCCCCCC
KKTIFLKYSLPKVLKRIGLHEDECLVFDDGLDAVLDYCKDTTGIRDLEQAAEHLAAHALY
CEEEEEEECHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEE
MIEVEHATSVSYTADMVNELF
EEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFKAQKEEYMLVYDANANSGSNAGFECTYTTFKSDNSTASPENPILVLDNSEKKWDETSY
CCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
GLFTNPYKKTAFDFQINGESFTSNILKIDSRFTSLIKWLGENRVKVKLTGANSSEGYNVY
CCEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEE
KIQEVAFGNGNKLSAEDGFLQFMIERLLESSAVAEDNSEEPDESADDMKLTSLTSISDFL
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHH
NCAGSTLPENIRLWARRNLVVARSSEVTPEEKRHAQRALSIMLNIKWKSNYFESIDPVEA
HHCCCCCCCHHEEEEECCEEEEECCCCCCHHHHHHHHHEEEEEEEEECCCCCCCCCHHHH
RRILDEELFGMESVKQRIIETVIQINRTHTLPAYGILLVGPAGTGKSQIAYLVAKILKMP
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
WTTLDMSSINDAEQLTGSSRIYSNAKPGIIMEAFNMAGESNLVFIINELDKATSSNGNAN
CCEEEHHCCCCHHHHCCCHHEECCCCCCEEEEHHHCCCCCCEEEEEECHHHHCCCCCCCC
PADVLLTLLDNLGFTDNYMECLIPTSGVYPIATANDKDKISAPLLSRFAVIDIPDYTREE
HHHHHHHHHHHCCCCCCHHHEEECCCCCEEEEECCCCHHHHHHHHHCEEEEECCCCCCCC
KKTIFLKYSLPKVLKRIGLHEDECLVFDDGLDAVLDYCKDTTGIRDLEQAAEHLAAHALY
CEEEEEEECHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEE
MIEVEHATSVSYTADMVNELF
EEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA