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The map label for this gene is xdhD [H]

Identifier: 238917415

GI number: 238917415

Start: 1549017

End: 1551305

Strand: Reverse

Name: xdhD [H]

Synonym: EUBELI_01493

Alternate gene names: 238917415

Gene position: 1551305-1549017 (Counterclockwise)

Preceding gene: 238917416

Following gene: 238917414

Centisome position: 72.35

GC content: 40.98

Gene sequence:

>2289_bases
ATGAAGTCGGTTAATAAAGCTATCAGAAAGAAAGATGCGATGGAACTGCTTCTTGGAAAGCCGGTGTATACAGATGATAT
TGCACCTAAGGACTGCCTTGTTGTAAAGCTTCTGCGCTCACCATATGCCAACGCATTTGTAAAGAATATTAATACTGATA
TTGCGATGAAGGTGCCGGGAATAGAAGCAATATTTACATATAAAGATGTTGACCAGAATATGAAAAGATTCACATGTGCA
GGTCAGACATATCCTGAGCCAAGTCCTTATGACAGGCTTATTCTTGATAAGCATGTAAGATTCATAGGTGATCCGGTTGC
CATTGTTGCAGGTGCTGATGAACGCTGTGTTGATAAGGCAATGAAGCTTATTAAGACAGAATATGAAGTACTTGAACCAT
TGCTTGATTTCACTAAGGCAAAGGATAATGAGATTCTTGTACATCCAGAGGATAACTGGGAGGCATTATGTCCGGTTGGA
GCTGATAATAAAAGAAATCTGTGTGCGCATGATGAGAGCGGCAACGGAGATATCGATAAGGTACTAGACGAGTGTGATAT
TGTGATTGACAGGACATATCATACTAAGGCATGCCAGCAGAGCATGATGGAGACTTTCAGAACTTTCTGTACAATAGATA
CTTATGGAAGACTTCATGTCGTAAGTTCTACACAGATAGTATTCCATTGCAGGAGAATTATTTCACATGCACTTGGAATA
TCGCCATCTAAGATAAGAGTTACCAAGCCAAGAATCGGAGGCGGATTTGGAGCAAAGCAGACATCTGTGTCAGAGATATA
TCCTGCATTTGTTACATGGAAGACCAAGAAACCGTCTAAGATTATATTTTCAAGGGAAGAAACACAGTCAGCTTCATCAC
CAAGACATGAGATGCAGATGCATGTAAGACTTGGTGCAACTAAGGATGGTATTGTAAAAGGAATTGATTTATACACATTA
TCTAATACAGGTGCATATGGCGAGCATGGGCCTACAACAGTAGGTCTTTCTGGACACAAGTCAATTCCATTATATGGAAA
GGCAGAGGCGTTCCGTTTTGTAAGTGATGTTGTATATACTAATATAATGTCAGCGGGTGCTTACAGAGGTTATGGTGCGA
CACAGGGTCTTTTTGCAGTTGAGTCGGCTGTAAATGAACTGGCAGACAAACTTCATATGGACCCGTTTGAAATCAGATTT
AAGAACATAGTAAAAGAGGGCGATGTAATGCCTGCTTACTATGGACAGGTTAATACAAGCTGTGCACTTGACAGATGTCT
TGCAAAGGTCAAAGAGATGATTAAATGGGATGAGAAATATCCTATGAGAAAGATTTCTGATACTAAGGCACGTTTTGTCG
GAATGGGCATGGCAATGCAGGGCTCAGGTATATCAGGAGTTGATGTCGGCAGTGCGACACTAAAGCTTAATGATGAAGGT
GTATATACTATGAACATCGGAGCTGCTGATATGGGAACAGGCTGTGATACAATACTTGCACAGATTGCAGCAGAGGTTCT
TGAATGCAGCACAGACGATATAAGTGTATTTGGTGCAGATACTGACATATCACCTTATGATTCAGGTTCATACGCATCAA
GTACAACATATGTAACTGGTAAGGCTGTTGAAAAATGTGCATTAGAGCTTAGAGACAGAATCGAAAAGCTTGGTGCTAAG
ATGTTAGGCTGCGAGAAATGTGATGTCACATTTGACGGAAAGAAAGTAATATGCGAATCAGGTGAGAACAAGGATAAATG
TGTAACCCTGGCCGATATATCAACAGCATCCATGTGTGGTAATGATATAGCACTTTCAGTTACCAATACACATACATCAC
CTATTTCACCACCACCATTCATGGTTGGAGCAGCGGAGGTCGAGGTTGACCTTCTCACAGGTGAGAGCCGTGTTGTTGAG
TATGACGCATGTGTTGATTGTGGAACACCTGTTAATCCTAACCTTGCAAGAGTACAGGCAGAGGGTGGTATCTTACAGGG
AATTGGAATGACAATGTCAGAGAATATCACATATTCAGATAAAGGCAAGCTGTATGAGAACTCATTTTTACAGTACAAGA
TTCCATCAAGAATGGATATTGGACATATTAATGTTGAGTTTGAGAGCAGTTACGAGAATGCAGGTCCTTTTGGTGCTAAA
TCAATCGGAGAGGTTGTAATTAATACACCGCTTCCTGCAATTACAGATGCATTAAGCCATGCGGCAGGAAAGAGATTTTA
CGAGCTTCCTATAACTCCTGACCAGATTGCAATGGCAAGACAGAAGTGA

Upstream 100 bases:

>100_bases
GTTCCTTTCAGGAAATCTGTGCAGATGTTCAGGTTATGAGGGACAGTTAAGAGGAATTATGAATTTCCTTGAGGCAAAGA
AAGCAAAGGAGGCTGAATAG

Downstream 100 bases:

>100_bases
TTATTTTGAGGAAATGAATGAAAGAAGAGATTAAATTATCAGATCATTTTGGATATAGGAAACTCATGAGATTCACAATG
CCATCAATTGTTATGCTGAT

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MKSVNKAIRKKDAMELLLGKPVYTDDIAPKDCLVVKLLRSPYANAFVKNINTDIAMKVPGIEAIFTYKDVDQNMKRFTCA
GQTYPEPSPYDRLILDKHVRFIGDPVAIVAGADERCVDKAMKLIKTEYEVLEPLLDFTKAKDNEILVHPEDNWEALCPVG
ADNKRNLCAHDESGNGDIDKVLDECDIVIDRTYHTKACQQSMMETFRTFCTIDTYGRLHVVSSTQIVFHCRRIISHALGI
SPSKIRVTKPRIGGGFGAKQTSVSEIYPAFVTWKTKKPSKIIFSREETQSASSPRHEMQMHVRLGATKDGIVKGIDLYTL
SNTGAYGEHGPTTVGLSGHKSIPLYGKAEAFRFVSDVVYTNIMSAGAYRGYGATQGLFAVESAVNELADKLHMDPFEIRF
KNIVKEGDVMPAYYGQVNTSCALDRCLAKVKEMIKWDEKYPMRKISDTKARFVGMGMAMQGSGISGVDVGSATLKLNDEG
VYTMNIGAADMGTGCDTILAQIAAEVLECSTDDISVFGADTDISPYDSGSYASSTTYVTGKAVEKCALELRDRIEKLGAK
MLGCEKCDVTFDGKKVICESGENKDKCVTLADISTASMCGNDIALSVTNTHTSPISPPPFMVGAAEVEVDLLTGESRVVE
YDACVDCGTPVNPNLARVQAEGGILQGIGMTMSENITYSDKGKLYENSFLQYKIPSRMDIGHINVEFESSYENAGPFGAK
SIGEVVINTPLPAITDALSHAAGKRFYELPITPDQIAMARQK

Sequences:

>Translated_762_residues
MKSVNKAIRKKDAMELLLGKPVYTDDIAPKDCLVVKLLRSPYANAFVKNINTDIAMKVPGIEAIFTYKDVDQNMKRFTCA
GQTYPEPSPYDRLILDKHVRFIGDPVAIVAGADERCVDKAMKLIKTEYEVLEPLLDFTKAKDNEILVHPEDNWEALCPVG
ADNKRNLCAHDESGNGDIDKVLDECDIVIDRTYHTKACQQSMMETFRTFCTIDTYGRLHVVSSTQIVFHCRRIISHALGI
SPSKIRVTKPRIGGGFGAKQTSVSEIYPAFVTWKTKKPSKIIFSREETQSASSPRHEMQMHVRLGATKDGIVKGIDLYTL
SNTGAYGEHGPTTVGLSGHKSIPLYGKAEAFRFVSDVVYTNIMSAGAYRGYGATQGLFAVESAVNELADKLHMDPFEIRF
KNIVKEGDVMPAYYGQVNTSCALDRCLAKVKEMIKWDEKYPMRKISDTKARFVGMGMAMQGSGISGVDVGSATLKLNDEG
VYTMNIGAADMGTGCDTILAQIAAEVLECSTDDISVFGADTDISPYDSGSYASSTTYVTGKAVEKCALELRDRIEKLGAK
MLGCEKCDVTFDGKKVICESGENKDKCVTLADISTASMCGNDIALSVTNTHTSPISPPPFMVGAAEVEVDLLTGESRVVE
YDACVDCGTPVNPNLARVQAEGGILQGIGMTMSENITYSDKGKLYENSFLQYKIPSRMDIGHINVEFESSYENAGPFGAK
SIGEVVINTPLPAITDALSHAAGKRFYELPITPDQIAMARQK
>Mature_762_residues
MKSVNKAIRKKDAMELLLGKPVYTDDIAPKDCLVVKLLRSPYANAFVKNINTDIAMKVPGIEAIFTYKDVDQNMKRFTCA
GQTYPEPSPYDRLILDKHVRFIGDPVAIVAGADERCVDKAMKLIKTEYEVLEPLLDFTKAKDNEILVHPEDNWEALCPVG
ADNKRNLCAHDESGNGDIDKVLDECDIVIDRTYHTKACQQSMMETFRTFCTIDTYGRLHVVSSTQIVFHCRRIISHALGI
SPSKIRVTKPRIGGGFGAKQTSVSEIYPAFVTWKTKKPSKIIFSREETQSASSPRHEMQMHVRLGATKDGIVKGIDLYTL
SNTGAYGEHGPTTVGLSGHKSIPLYGKAEAFRFVSDVVYTNIMSAGAYRGYGATQGLFAVESAVNELADKLHMDPFEIRF
KNIVKEGDVMPAYYGQVNTSCALDRCLAKVKEMIKWDEKYPMRKISDTKARFVGMGMAMQGSGISGVDVGSATLKLNDEG
VYTMNIGAADMGTGCDTILAQIAAEVLECSTDDISVFGADTDISPYDSGSYASSTTYVTGKAVEKCALELRDRIEKLGAK
MLGCEKCDVTFDGKKVICESGENKDKCVTLADISTASMCGNDIALSVTNTHTSPISPPPFMVGAAEVEVDLLTGESRVVE
YDACVDCGTPVNPNLARVQAEGGILQGIGMTMSENITYSDKGKLYENSFLQYKIPSRMDIGHINVEFESSYENAGPFGAK
SIGEVVINTPLPAITDALSHAAGKRFYELPITPDQIAMARQK

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=779, Percent_Identity=26.3157894736842, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI71773480, Length=776, Percent_Identity=24.8711340206186, Blast_Score=158, Evalue=2e-38,
Organism=Escherichia coli, GI1789246, Length=803, Percent_Identity=35.1183063511831, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1789230, Length=762, Percent_Identity=32.2834645669291, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1786478, Length=584, Percent_Identity=26.1986301369863, Blast_Score=136, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17540638, Length=783, Percent_Identity=24.5210727969349, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566215, Length=536, Percent_Identity=27.4253731343284, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=715, Percent_Identity=23.2167832167832, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737937, Length=769, Percent_Identity=23.407022106632, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24647193, Length=794, Percent_Identity=23.551637279597, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24647199, Length=786, Percent_Identity=22.0101781170483, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24647201, Length=750, Percent_Identity=21.2, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 83281; Mature: 83281

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVNKAIRKKDAMELLLGKPVYTDDIAPKDCLVVKLLRSPYANAFVKNINTDIAMKVPG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCEEEECCC
IEAIFTYKDVDQNMKRFTCAGQTYPEPSPYDRLILDKHVRFIGDPVAIVAGADERCVDKA
CEEEEEEHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
MKLIKTEYEVLEPLLDFTKAKDNEILVHPEDNWEALCPVGADNKRNLCAHDESGNGDIDK
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCCEECCCCCCCCCHHH
VLDECDIVIDRTYHTKACQQSMMETFRTFCTIDTYGRLHVVSSTQIVFHCRRIISHALGI
HHHHCCEEEECCCCHHHHHHHHHHHHHHHEEEECCCEEEEEECHHHHHHHHHHHHHHHCC
SPSKIRVTKPRIGGGFGAKQTSVSEIYPAFVTWKTKKPSKIIFSREETQSASSPRHEMQM
CCCEEEEECCCCCCCCCCCCCCHHHHCCEEEEEECCCCCEEEEECHHHCCCCCCHHHEEE
HVRLGATKDGIVKGIDLYTLSNTGAYGEHGPTTVGLSGHKSIPLYGKAEAFRFVSDVVYT
EEEECCCCCCCEECEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NIMSAGAYRGYGATQGLFAVESAVNELADKLHMDPFEIRFKNIVKEGDVMPAYYGQVNTS
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCH
CALDRCLAKVKEMIKWDEKYPMRKISDTKARFVGMGMAMQGSGISGVDVGSATLKLNDEG
HHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHEECCEEECCCCCCCEECCCEEEEECCCC
VYTMNIGAADMGTGCDTILAQIAAEVLECSTDDISVFGADTDISPYDSGSYASSTTYVTG
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEH
KAVEKCALELRDRIEKLGAKMLGCEKCDVTFDGKKVICESGENKDKCVTLADISTASMCG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCEEEEECCCHHHHCC
NDIALSVTNTHTSPISPPPFMVGAAEVEVDLLTGESRVVEYDACVDCGTPVNPNLARVQA
CCEEEEEECCCCCCCCCCCEEEEEEEEEEEEEECCCEEEEEECEECCCCCCCCCCEEEEE
EGGILQGIGMTMSENITYSDKGKLYENSFLQYKIPSRMDIGHINVEFESSYENAGPFGAK
CCCEEEECCCEEECCEEECCCCCEECCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCC
SIGEVVINTPLPAITDALSHAAGKRFYELPITPDQIAMARQK
CCCCEEECCCCHHHHHHHHHHHCCEEEECCCCHHHHHHCCCC
>Mature Secondary Structure
MKSVNKAIRKKDAMELLLGKPVYTDDIAPKDCLVVKLLRSPYANAFVKNINTDIAMKVPG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCEEEECCC
IEAIFTYKDVDQNMKRFTCAGQTYPEPSPYDRLILDKHVRFIGDPVAIVAGADERCVDKA
CEEEEEEHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
MKLIKTEYEVLEPLLDFTKAKDNEILVHPEDNWEALCPVGADNKRNLCAHDESGNGDIDK
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCCCCCEECCCCCCCCCHHH
VLDECDIVIDRTYHTKACQQSMMETFRTFCTIDTYGRLHVVSSTQIVFHCRRIISHALGI
HHHHCCEEEECCCCHHHHHHHHHHHHHHHEEEECCCEEEEEECHHHHHHHHHHHHHHHCC
SPSKIRVTKPRIGGGFGAKQTSVSEIYPAFVTWKTKKPSKIIFSREETQSASSPRHEMQM
CCCEEEEECCCCCCCCCCCCCCHHHHCCEEEEEECCCCCEEEEECHHHCCCCCCHHHEEE
HVRLGATKDGIVKGIDLYTLSNTGAYGEHGPTTVGLSGHKSIPLYGKAEAFRFVSDVVYT
EEEECCCCCCCEECEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NIMSAGAYRGYGATQGLFAVESAVNELADKLHMDPFEIRFKNIVKEGDVMPAYYGQVNTS
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCH
CALDRCLAKVKEMIKWDEKYPMRKISDTKARFVGMGMAMQGSGISGVDVGSATLKLNDEG
HHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHEECCEEECCCCCCCEECCCEEEEECCCC
VYTMNIGAADMGTGCDTILAQIAAEVLECSTDDISVFGADTDISPYDSGSYASSTTYVTG
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEH
KAVEKCALELRDRIEKLGAKMLGCEKCDVTFDGKKVICESGENKDKCVTLADISTASMCG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCEEEEECCCHHHHCC
NDIALSVTNTHTSPISPPPFMVGAAEVEVDLLTGESRVVEYDACVDCGTPVNPNLARVQA
CCEEEEEECCCCCCCCCCCEEEEEEEEEEEEEECCCEEEEEECEECCCCCCCCCCEEEEE
EGGILQGIGMTMSENITYSDKGKLYENSFLQYKIPSRMDIGHINVEFESSYENAGPFGAK
CCCEEEECCCEEECCEEECCCCCEECCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCC
SIGEVVINTPLPAITDALSHAAGKRFYELPITPDQIAMARQK
CCCCEEECCCCHHHHHHHHHHHCCEEEECCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Two 2Fe-2S centers [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]