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The map label for this gene is trpF [H]

Identifier: 238917230

GI number: 238917230

Start: 1340631

End: 1341284

Strand: Reverse

Name: trpF [H]

Synonym: EUBELI_01303

Alternate gene names: 238917230

Gene position: 1341284-1340631 (Counterclockwise)

Preceding gene: 238917231

Following gene: 238917229

Centisome position: 62.55

GC content: 38.23

Gene sequence:

>654_bases
ATGCTGAAAGAAAATGATTCTTTAGTACAGGTTAAGATATGCGGACTTACAAGTATGGATGATGTACACATTATAGAAAA
ATATGGTGCTGACTATGCAGGTATGGTACTATATTATCCAAAAAGCAAACGCAATATTGACATTAATCTGGCAGCGGTGC
TTGTTGCACAATTGAAGAAATCGGACATCAAGAGCGTTGCTGTTGTTGTGTCCCCCGATGTATCACAGCTTGAAGCAATA
CAGAATGCAGGATTTGATTATATACAGATTCACGGTGAATTAAGTGATGATGTGTATAATGCATGCAGTGTCAGGATTAT
AAGAGCCGTTAACATTAAGCATCAGTCAGAAGAAGATATATATCTGGAGACTAAGCGATGGCGAAGTCTGGATAAAATAT
ATGGACTGCTTTTTGATGCGGGAGTTCCGGGGAGCGGTAAGACATTCGACTGGGAAAGTCTTAAAAAAGCGGACTGCGGT
AATAAAAAATTATTCCTTGCAGGAGGACTTACACCAGACAATGTAAAAGCTGCGATAGAAGCAGTAAGGTCTGATGTTGT
TGATATAAGTTCGGGCGTTGAATATGATGATGTGTCCGTTAAAGGAAAAGATGAGAGTAAAGTTAAAGCATTTATACAGA
ATGCAAAATATTAA

Upstream 100 bases:

>100_bases
GTGCTGGCAAAGAGTGGAGCAGATGCACTTCTTATAGGAACAGTGCTTATGGAAGCACCGAAGCCGGAAGAATTAATATC
AGAGTTTAAAGAGGTATATA

Downstream 100 bases:

>100_bases
GAAAAAGAGGTAAAGAGAAAATGGCAGAAAGCAAGTATTATGGACAGTTTGGAGGACAGTATGTTTCAGAGTCACTTATG
AATACTCTGGCAGAGCTTGA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MLKENDSLVQVKICGLTSMDDVHIIEKYGADYAGMVLYYPKSKRNIDINLAAVLVAQLKKSDIKSVAVVVSPDVSQLEAI
QNAGFDYIQIHGELSDDVYNACSVRIIRAVNIKHQSEEDIYLETKRWRSLDKIYGLLFDAGVPGSGKTFDWESLKKADCG
NKKLFLAGGLTPDNVKAAIEAVRSDVVDISSGVEYDDVSVKGKDESKVKAFIQNAKY

Sequences:

>Translated_217_residues
MLKENDSLVQVKICGLTSMDDVHIIEKYGADYAGMVLYYPKSKRNIDINLAAVLVAQLKKSDIKSVAVVVSPDVSQLEAI
QNAGFDYIQIHGELSDDVYNACSVRIIRAVNIKHQSEEDIYLETKRWRSLDKIYGLLFDAGVPGSGKTFDWESLKKADCG
NKKLFLAGGLTPDNVKAAIEAVRSDVVDISSGVEYDDVSVKGKDESKVKAFIQNAKY
>Mature_217_residues
MLKENDSLVQVKICGLTSMDDVHIIEKYGADYAGMVLYYPKSKRNIDINLAAVLVAQLKKSDIKSVAVVVSPDVSQLEAI
QNAGFDYIQIHGELSDDVYNACSVRIIRAVNIKHQSEEDIYLETKRWRSLDKIYGLLFDAGVPGSGKTFDWESLKKADCG
NKKLFLAGGLTPDNVKAAIEAVRSDVVDISSGVEYDDVSVKGKDESKVKAFIQNAKY

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=29.6803652968037, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23957; Mature: 23957

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKENDSLVQVKICGLTSMDDVHIIEKYGADYAGMVLYYPKSKRNIDINLAAVLVAQLKK
CCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHH
SDIKSVAVVVSPDVSQLEAIQNAGFDYIQIHGELSDDVYNACSVRIIRAVNIKHQSEEDI
CCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEEEECCCCCCCCCE
YLETKRWRSLDKIYGLLFDAGVPGSGKTFDWESLKKADCGNKKLFLAGGLTPDNVKAAIE
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
AVRSDVVDISSGVEYDDVSVKGKDESKVKAFIQNAKY
HHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLKENDSLVQVKICGLTSMDDVHIIEKYGADYAGMVLYYPKSKRNIDINLAAVLVAQLKK
CCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHH
SDIKSVAVVVSPDVSQLEAIQNAGFDYIQIHGELSDDVYNACSVRIIRAVNIKHQSEEDI
CCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEEEECCCCCCCCCE
YLETKRWRSLDKIYGLLFDAGVPGSGKTFDWESLKKADCGNKKLFLAGGLTPDNVKAAIE
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
AVRSDVVDISSGVEYDDVSVKGKDESKVKAFIQNAKY
HHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]