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The map label for this gene is trpC

Identifier: 238917231

GI number: 238917231

Start: 1341268

End: 1342074

Strand: Reverse

Name: trpC

Synonym: EUBELI_01304

Alternate gene names: 238917231

Gene position: 1342074-1341268 (Counterclockwise)

Preceding gene: 238917232

Following gene: 238917230

Centisome position: 62.59

GC content: 38.04

Gene sequence:

>807_bases
ATGATATTAGATGTTATTGTAGAGGATAAGTTAAAAAGACTTCCAGAACACAAGAAAAGAATCAGTGAAGAGGAGATGAC
AAGACTTGCGATTGAGAGCCAGAGAGTGTCACACAGCTTCTATGATGCACTTGCAAAGGACGGCCTTTCAATTATAAGTG
AGTTCAAGAAAGCATCACCAAGTCATGGTAATATGAACAATAAGATTACTCTGGAAAAAAGAATAAAACAGTACGGCGAA
AGCGCAGATGCTATTTCATGTCTTACAGAGGAAGACCATTTTAAGGGAAGTACAGAATATCTTAAGCAGATAAGACAGAT
GACAGACCTTCCGATTATCAGAAAGGATTTCATAATTGATCCATATCAGGTGTATGAAGCAAAGGTAATAGGAGCGGATG
CAGTTCTTCTCATTGCTGCGATTCTTGATGACAGTAGATTTAAAGAACTATATGACCTTGCTTACAGTTTAGGACTTGAT
GTTTTATGCGAGGTTCATAACGAAGAGGAAATGCAGAGAATGCTGAATCTTGATGTGAAGATTATAGGAATTAACAACCG
TAATCTTAAGACATTTGAGGTTGACCTTGATACTACGAAAAAACTTGCAGATATGGTTACACCAGAGATGAGAAAAGCTG
GAAAACTGCTTGTATCAGAAAGCGGTGTTGCGGATACAGACGATATTAAGGTGCTGGCAAAGAGTGGAGCAGATGCACTT
CTTATAGGAACAGTGCTTATGGAAGCACCGAAGCCGGAAGAATTAATATCAGAGTTTAAAGAGGTATATAATGCTGAAAG
AAAATGA

Upstream 100 bases:

>100_bases
ATGAGGATTATCCGGTGGTCGGATTGCAGTTCCATCCGGAGTCAATATATACAGAGCATGGCAAGAGAATGATTGAGAAT
TTTGTTAATGGGGTGATTTA

Downstream 100 bases:

>100_bases
TTCTTTAGTACAGGTTAAGATATGCGGACTTACAAGTATGGATGATGTACACATTATAGAAAAATATGGTGCTGACTATG
CAGGTATGGTACTATATTAT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MILDVIVEDKLKRLPEHKKRISEEEMTRLAIESQRVSHSFYDALAKDGLSIISEFKKASPSHGNMNNKITLEKRIKQYGE
SADAISCLTEEDHFKGSTEYLKQIRQMTDLPIIRKDFIIDPYQVYEAKVIGADAVLLIAAILDDSRFKELYDLAYSLGLD
VLCEVHNEEEMQRMLNLDVKIIGINNRNLKTFEVDLDTTKKLADMVTPEMRKAGKLLVSESGVADTDDIKVLAKSGADAL
LIGTVLMEAPKPEELISEFKEVYNAERK

Sequences:

>Translated_268_residues
MILDVIVEDKLKRLPEHKKRISEEEMTRLAIESQRVSHSFYDALAKDGLSIISEFKKASPSHGNMNNKITLEKRIKQYGE
SADAISCLTEEDHFKGSTEYLKQIRQMTDLPIIRKDFIIDPYQVYEAKVIGADAVLLIAAILDDSRFKELYDLAYSLGLD
VLCEVHNEEEMQRMLNLDVKIIGINNRNLKTFEVDLDTTKKLADMVTPEMRKAGKLLVSESGVADTDDIKVLAKSGADAL
LIGTVLMEAPKPEELISEFKEVYNAERK
>Mature_268_residues
MILDVIVEDKLKRLPEHKKRISEEEMTRLAIESQRVSHSFYDALAKDGLSIISEFKKASPSHGNMNNKITLEKRIKQYGE
SADAISCLTEEDHFKGSTEYLKQIRQMTDLPIIRKDFIIDPYQVYEAKVIGADAVLLIAAILDDSRFKELYDLAYSLGLD
VLCEVHNEEEMQRMLNLDVKIIGINNRNLKTFEVDLDTTKKLADMVTPEMRKAGKLLVSESGVADTDDIKVLAKSGADAL
LIGTVLMEAPKPEELISEFKEVYNAERK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=246, Percent_Identity=37.8048780487805, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=233, Percent_Identity=36.0515021459227, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_EUBE2 (C4Z138)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930748.1
- GeneID:   7956650
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01304
- OMA:   VDLPLLC
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 30352; Mature: 30352

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDVIVEDKLKRLPEHKKRISEEEMTRLAIESQRVSHSFYDALAKDGLSIISEFKKASP
CEEHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHGNMNNKITLEKRIKQYGESADAISCLTEEDHFKGSTEYLKQIRQMTDLPIIRKDFIID
CCCCCCCEEEHHHHHHHHCCCCHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCHHHHHCCC
PYQVYEAKVIGADAVLLIAAILDDSRFKELYDLAYSLGLDVLCEVHNEEEMQRMLNLDVK
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHCCCEE
IIGINNRNLKTFEVDLDTTKKLADMVTPEMRKAGKLLVSESGVADTDDIKVLAKSGADAL
EEEECCCCCEEEEECCCHHHHHHHHCCHHHHHHCCEEEECCCCCCCHHHHHHHHCCCCHH
LIGTVLMEAPKPEELISEFKEVYNAERK
HHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILDVIVEDKLKRLPEHKKRISEEEMTRLAIESQRVSHSFYDALAKDGLSIISEFKKASP
CEEHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHGNMNNKITLEKRIKQYGESADAISCLTEEDHFKGSTEYLKQIRQMTDLPIIRKDFIID
CCCCCCCEEEHHHHHHHHCCCCHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCHHHHHCCC
PYQVYEAKVIGADAVLLIAAILDDSRFKELYDLAYSLGLDVLCEVHNEEEMQRMLNLDVK
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHCCCEE
IIGINNRNLKTFEVDLDTTKKLADMVTPEMRKAGKLLVSESGVADTDDIKVLAKSGADAL
EEEECCCCCEEEEECCCHHHHHHHHCCHHHHHHCCEEEECCCCCCCHHHHHHHHCCCCHH
LIGTVLMEAPKPEELISEFKEVYNAERK
HHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA