Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 238917146

GI number: 238917146

Start: 1233450

End: 1235759

Strand: Reverse

Name: gyrA [H]

Synonym: EUBELI_01218

Alternate gene names: 238917146

Gene position: 1235759-1233450 (Counterclockwise)

Preceding gene: 238917147

Following gene: 238917143

Centisome position: 57.63

GC content: 38.83

Gene sequence:

>2310_bases
ATGGCTGAGAAGATTATAAGGACTGAGTATTCTGAGGTTATGCAGAAGTCCTATATAGATTATTCCATGAGTGTTATTAC
AGCAAGAGCACTTCCTGATGTAAGAGACGGTTTAAAGCCGGTACAGAGAAGAGTGCTGTATGCCATGGACCGGTTGGGGC
TTAATTACGACAAGCCTCACAGAAAGTCTGCACGTATCGTTGGTGATACAATGGGTAAATACCATCCACATGGTGACAGT
TCAATATATGAGACACTCGTTGTACTTTCACAGGATTTTAAGAAGGGTATGGCTCTTGTTGACGGACACGGAAACTTCGG
TTCTATCGAAGGTGACGGAGCTGCCGCTATGCGATATACAGAAGCTAAGTTAAAAAAGTTCACACAGGACGTATATCTTG
CTGACCTTGATAAAAATGTTGTGGATTTCGTGCCTAACTTTGATGAGACAGAAAAAGAGCCTGAGGTTCTTCCTGTAAGA
GTACCTAATCTGCTTGTAAATGGTGCAGATGGTATTGCGGTTGGTATGACAACTAATATCCCTCCACACAATCTTTCAGA
GGTTGTTGATGCAGTATGTGCATATATGGATAATGAGGATATCACAACAGACGAGCTTATGCAGCTCTGCCCTGGACCGG
ATTTTCCTACAGGCGGAATTGTAATTAATAAAAGCGAGCTTGGTGCAATATATGAGACTGGAACAGGTAAGATTAAGTTA
AGAGGCAAGGTCATATTCGAGCCTGCCAAGAACCGTTCTGAGAAGGACAAGCTTGTTATTACAGAGATTCCATATACAAT
GATTGGTGCTAACATAGGTAAATTTATATCTGATGTTGTAAGCCTTATAGAGACTAAGAAAACTACCGATATTGTCGACA
TTTCCAATGAATCTTCTAAGGAAGGAATAAGAATTGTCCTTGAACTTAAGAAGAACGCTGATGTCAAGAATCTTGAAAAT
CTTCTTTACAAGAAGACCAAGTTGGAAGATACATTTGGCGTAAATATGCTGGCTATCGTTGATGGAAGACCTGAGACCTT
AGGTATTAAGGATATAATAAAACACCACATTAATTTCCAGTATGAGCTTGCTACAAGAAAGTACACAACACTTCTTGAAA
AGGAGAAGGCTAACAGGGAGATTAAGGAAGGTCTTATAAGAGCATGTGATATTATTGACCTTATTATCGAGATATTACGA
GGCAGTGCTAATCTTAAGATGGCTAAGGACTGCCTTGTTAATGGTAATGTTGAGGGAATCAAGTTTAAGTCAGAGCAGTC
AAAAAAGCAGGCTGCAGGTCTTGATTTCACAGAAAGACAGGCTGGCGCAATATTGGAAATGCGTCTGTACAAGCTGATTG
GCCTTGAAATTCTTAATCTTCAGAAAGAATATGATGAATGTGTCAAGAAGATTGAGAAGTATGAAAAGATACTTGGCAGC
AGAAAAGAGATGGCTAAGGTTATCAAGGCTGACCTTCTTAATATTAAAAAGGAATATGGTGTTGAAAGAAGAACTGTAAT
TGAAGACGGAGAAGCTGCTGTATTTGAGGAAAAGAAGATTCCAGAGATGGAAGTTATGTTTATTATGGACAGATTCGGAT
ATGCAAGAACCATTGATATGGCTGCATTTGAGAGAAATAAAGATGCTGTATTTAATGAGAACAAATATGTCATTCCGGTA
ATGAACACAGATAAAATCTGCATATTTACTGATACGGGAGATCTGCACCAGTTAAAGATAAAGGATCTGCCATTCACTAA
GTTCAGAGATAAAGGCACACCGATTGATAATCTGTGTAACTATGACAGTTCTAAGGAGATAATTGTGTACATTACTCCAT
TTGAACGACTTAAGAATCAGAAAATGCTTTTTGTTACAAGACAGGGAATGATGAAGCTTGTAGACAGCGAAGAATTCCAG
GTTGCAAAGCGTACAGTTGCATGTACAAAATTAGCAGATGACGATAAACTTATCGGAATGTATTCAACAGACGCAAGAGT
AGAGATTTATTCAAAGTTCTCACTTGATGGAGAAATCAAGGAAGAAGAGGTTGTCGAGAGCAACCAGAATGTAATTGTAC
AGACAGAAAATGGAGTGTTCTTAAAGTTCCCATTAACAGATATTCCAATGAAGAAGAAGAGTGCTGTTGGCGTAAGAGGA
ATCAAGCTTTCAAAAGATGATTATATAGAAGATGTATTCCTGCTTACAGAAGGTGACGAGTTCACAATGGAATATAAGGG
CAAGAGTATCAGCTTTGCCAAGATGAAGACGGCACACAGGGATACTAAGGGGACTAAGATAAGAGTATAG

Upstream 100 bases:

>100_bases
AGCAATGCTTATGGGTACAGATGTACCACCTAGAAGAGAATTTATATATACGCATGCTAATGAAGCTGAGATTGATGCGT
AAAAGCTAAAGGAGTAGAAA

Downstream 100 bases:

>100_bases
TTGTTTAACGGTTGGAGAGTCGAAGAAGTGCTTCACACCATCACAACTAAGGTAAGCGGTCCTAGTGGCTGTAAATGCCG
CCATATACAGAGTTTATAAC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MAEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPHRKSARIVGDTMGKYHPHGDS
SIYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYTEAKLKKFTQDVYLADLDKNVVDFVPNFDETEKEPEVLPVR
VPNLLVNGADGIAVGMTTNIPPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKL
RGKVIFEPAKNRSEKDKLVITEIPYTMIGANIGKFISDVVSLIETKKTTDIVDISNESSKEGIRIVLELKKNADVKNLEN
LLYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQYELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILR
GSANLKMAKDCLVNGNVEGIKFKSEQSKKQAAGLDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGS
RKEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDMAAFERNKDAVFNENKYVIPV
MNTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCNYDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQ
VAKRTVACTKLADDDKLIGMYSTDARVEIYSKFSLDGEIKEEEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRG
IKLSKDDYIEDVFLLTEGDEFTMEYKGKSISFAKMKTAHRDTKGTKIRV

Sequences:

>Translated_769_residues
MAEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPHRKSARIVGDTMGKYHPHGDS
SIYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYTEAKLKKFTQDVYLADLDKNVVDFVPNFDETEKEPEVLPVR
VPNLLVNGADGIAVGMTTNIPPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKL
RGKVIFEPAKNRSEKDKLVITEIPYTMIGANIGKFISDVVSLIETKKTTDIVDISNESSKEGIRIVLELKKNADVKNLEN
LLYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQYELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILR
GSANLKMAKDCLVNGNVEGIKFKSEQSKKQAAGLDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGS
RKEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDMAAFERNKDAVFNENKYVIPV
MNTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCNYDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQ
VAKRTVACTKLADDDKLIGMYSTDARVEIYSKFSLDGEIKEEEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRG
IKLSKDDYIEDVFLLTEGDEFTMEYKGKSISFAKMKTAHRDTKGTKIRV
>Mature_768_residues
AEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPHRKSARIVGDTMGKYHPHGDSS
IYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYTEAKLKKFTQDVYLADLDKNVVDFVPNFDETEKEPEVLPVRV
PNLLVNGADGIAVGMTTNIPPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKLR
GKVIFEPAKNRSEKDKLVITEIPYTMIGANIGKFISDVVSLIETKKTTDIVDISNESSKEGIRIVLELKKNADVKNLENL
LYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQYELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILRG
SANLKMAKDCLVNGNVEGIKFKSEQSKKQAAGLDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGSR
KEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDMAAFERNKDAVFNENKYVIPVM
NTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCNYDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQV
AKRTVACTKLADDDKLIGMYSTDARVEIYSKFSLDGEIKEEEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRGI
KLSKDDYIEDVFLLTEGDEFTMEYKGKSISFAKMKTAHRDTKGTKIRV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=262, Percent_Identity=28.6259541984733, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI19913406, Length=198, Percent_Identity=30.8080808080808, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=798, Percent_Identity=37.0927318295739, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789396, Length=544, Percent_Identity=37.1323529411765, Blast_Score=342, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI17535065, Length=168, Percent_Identity=36.3095238095238, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=185, Percent_Identity=33.5135135135135, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=324, Percent_Identity=25.6172839506173, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=335, Percent_Identity=28.3582089552239, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136538, Length=252, Percent_Identity=29.7619047619048, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 86998; Mature: 86867

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPH
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RKSARIVGDTMGKYHPHGDSSIYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYT
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHH
EAKLKKFTQDVYLADLDKNVVDFVPNFDETEKEPEVLPVRVPNLLVNGADGIAVGMTTNI
HHHHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCEEEEECCCEEEECCCCEEEEEECCC
PPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKL
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCEEEE
RGKVIFEPAKNRSEKDKLVITEIPYTMIGANIGKFISDVVSLIETKKTTDIVDISNESSK
EEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCC
EGIRIVLELKKNADVKNLENLLYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQ
CCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHCCEEEEEECCCCCCCCHHHHHHHHCCEE
YELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILRGSANLKMAKDCLVNGNVEGI
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCE
KFKSEQSKKQAAGLDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGS
EECCHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDM
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCCCEEHHHHHCCCCEEEEH
AAFERNKDAVFNENKYVIPVMNTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCN
HHHHCCCCCEECCCCEEEEEECCCEEEEEECCCCEEEEEECCCCCHHCCCCCCCHHHHHC
YDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQVAKRTVACTKLADDDKLIGM
CCCCCCEEEEECCHHHHCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHEECCCCCEEEE
YSTDARVEIYSKFSLDGEIKEEEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRG
ECCCCEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEE
IKLSKDDYIEDVFLLTEGDEFTMEYKGKSISFAKMKTAHRDTKGTKIRV
EEECCCCCCCEEEEEECCCEEEEEECCCEEEHHHHHHHHCCCCCCEEEC
>Mature Secondary Structure 
AEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RKSARIVGDTMGKYHPHGDSSIYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYT
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHH
EAKLKKFTQDVYLADLDKNVVDFVPNFDETEKEPEVLPVRVPNLLVNGADGIAVGMTTNI
HHHHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCEEEEECCCEEEECCCCEEEEEECCC
PPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKL
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCEEEE
RGKVIFEPAKNRSEKDKLVITEIPYTMIGANIGKFISDVVSLIETKKTTDIVDISNESSK
EEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCC
EGIRIVLELKKNADVKNLENLLYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQ
CCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHCCEEEEEECCCCCCCCHHHHHHHHCCEE
YELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILRGSANLKMAKDCLVNGNVEGI
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCE
KFKSEQSKKQAAGLDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGS
EECCHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDM
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCCCEEHHHHHCCCCEEEEH
AAFERNKDAVFNENKYVIPVMNTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCN
HHHHCCCCCEECCCCEEEEEECCCEEEEEECCCCEEEEEECCCCCHHCCCCCCCHHHHHC
YDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQVAKRTVACTKLADDDKLIGM
CCCCCCEEEEECCHHHHCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHEECCCCCEEEE
YSTDARVEIYSKFSLDGEIKEEEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRG
ECCCCEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEE
IKLSKDDYIEDVFLLTEGDEFTMEYKGKSISFAKMKTAHRDTKGTKIRV
EEECCCCCCCEEEEEECCCEEEEEECCCEEEHHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]