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The map label for this gene is comEA [H]

Identifier: 238917143

GI number: 238917143

Start: 1228053

End: 1228658

Strand: Reverse

Name: comEA [H]

Synonym: EUBELI_01215

Alternate gene names: 238917143

Gene position: 1228658-1228053 (Counterclockwise)

Preceding gene: 238917146

Following gene: 238917142

Centisome position: 57.3

GC content: 38.12

Gene sequence:

>606_bases
ATGAATTATAAAAGAATATTTGTTAAACATAAAGAAACTGTTAAATACTGTATGTGCGCAGTTGTATTGCTGGTTACAGG
AACTGTATATTTTTCTGCCGGACAGAAGAAGCGTGAGTATGGGAATACAGTTATAATAACACAGGCAGACACAGAGAATG
AAGAATGCACGGATGAAGTGCAGGCAGAGAATGATATATATGTATATGTATGTGGAGATGTGCTTGAACCAGGAGTTATA
AAATGTGCTGCAGGAACAAGAATGTATGAGGCAGTACAGATGGCAGGTGGTATGGCTGAATGCGCTGACACAGCAGCTCT
TAATATGGCTGGTATTCTTTCTGATGGTGACAGGGTATATATACCCTGTGAAAGTGAACATATATCAGAAACTGATGGTA
CAGTGTCAACCTCAGGACTGGTTAATATTAACAGGGCAACGGAGAATGAGCTTATGACTCTTCCGGGAATTGGAAGTTCA
AGAGCGGCAGACATAATTAATTACAGGAATACTAATGGCAGATTTGACAGGATTGAGGATATAATGAAGGTATCCGGGAT
AAAAGAGTCCGCATTTAATAAAATTAAGAATTATATAAGTGTATAA

Upstream 100 bases:

>100_bases
ATTTAAACTAAAATTAGGCTTGTATTCGTTGTAACAATTCTGTAAAATATAAAGGTACGCAAAGGGAATTTCCTTGACCT
GTAAGTTAAGGAGATTGTAC

Downstream 100 bases:

>100_bases
AAAGAAAAAGGAGAAGGATATGGCAGGCAGAGTATTGGTTGTTGATGATGAGAAAATGATAGTTAAGGGACTTAAATTCA
GTCTTATGCAGGATTACAGT

Product: competence protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MNYKRIFVKHKETVKYCMCAVVLLVTGTVYFSAGQKKREYGNTVIITQADTENEECTDEVQAENDIYVYVCGDVLEPGVI
KCAAGTRMYEAVQMAGGMAECADTAALNMAGILSDGDRVYIPCESEHISETDGTVSTSGLVNINRATENELMTLPGIGSS
RAADIINYRNTNGRFDRIEDIMKVSGIKESAFNKIKNYISV

Sequences:

>Translated_201_residues
MNYKRIFVKHKETVKYCMCAVVLLVTGTVYFSAGQKKREYGNTVIITQADTENEECTDEVQAENDIYVYVCGDVLEPGVI
KCAAGTRMYEAVQMAGGMAECADTAALNMAGILSDGDRVYIPCESEHISETDGTVSTSGLVNINRATENELMTLPGIGSS
RAADIINYRNTNGRFDRIEDIMKVSGIKESAFNKIKNYISV
>Mature_201_residues
MNYKRIFVKHKETVKYCMCAVVLLVTGTVYFSAGQKKREYGNTVIITQADTENEECTDEVQAENDIYVYVCGDVLEPGVI
KCAAGTRMYEAVQMAGGMAECADTAALNMAGILSDGDRVYIPCESEHISETDGTVSTSGLVNINRATENELMTLPGIGSS
RAADIINYRNTNGRFDRIEDIMKVSGIKESAFNKIKNYISV

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 22057; Mature: 22057

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKRIFVKHKETVKYCMCAVVLLVTGTVYFSAGQKKREYGNTVIITQADTENEECTDEV
CCCEEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCEEEEEECCCCCCHHHHHH
QAENDIYVYVCGDVLEPGVIKCAAGTRMYEAVQMAGGMAECADTAALNMAGILSDGDRVY
CCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCEEE
IPCESEHISETDGTVSTSGLVNINRATENELMTLPGIGSSRAADIINYRNTNGRFDRIED
EECCCCCCCCCCCCEECCCEEEEECCCCCCEEECCCCCCCHHHHHHEECCCCCCHHHHHH
IMKVSGIKESAFNKIKNYISV
HHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYKRIFVKHKETVKYCMCAVVLLVTGTVYFSAGQKKREYGNTVIITQADTENEECTDEV
CCCEEEEEECHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCEEEEEECCCCCCHHHHHH
QAENDIYVYVCGDVLEPGVIKCAAGTRMYEAVQMAGGMAECADTAALNMAGILSDGDRVY
CCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCEEE
IPCESEHISETDGTVSTSGLVNINRATENELMTLPGIGSSRAADIINYRNTNGRFDRIED
EECCCCCCCCCCCCEECCCEEEEECCCCCCEEECCCCCCCHHHHHHEECCCCCCHHHHHH
IMKVSGIKESAFNKIKNYISV
HHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]