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The map label for this gene is argH

Identifier: 238917145

GI number: 238917145

Start: 1231546

End: 1232922

Strand: Direct

Name: argH

Synonym: EUBELI_01217

Alternate gene names: 238917145

Gene position: 1231546-1232922 (Clockwise)

Preceding gene: 238917144

Following gene: 238917165

Centisome position: 57.44

GC content: 39.51

Gene sequence:

>1377_bases
ATGAAATTATGGGGTGGACGATTCACCAAAGAAACTAATGAGCTTGTCAACAACTTCAACGCATCAATTTCATTTGACCA
GAAGTTCTATAAGCAGGATATTGAAGGAAGTATTGCACATGCTACTATGCTCGGCAAGCAGGGAATTATTCCTGAAAGCG
AAAGTGAGCAGATTGTAGAAGGTCTTAAGGGAATTCTTGCTGATATTGAATCAGGAAAGCTTGAAATCACTGATGAATAC
GAGGATATCCATACATTTATGGAGGCTACTCTTATTGAGAGAATCGGTGATGCCGGAAAGAGACTTCACACAGGACGAAG
CAGAAATGACCAGGTTGCTCTTGATATGAGACTTTTCACAAGACAGGAAGTTCTTAATACTGATGCTGAGCTTAAAGAGC
TTATGGCTGTTATCTTAAGAATCATGAAAGAAAATACACATACATTTATGCCTGGTTTTACTCATCTTCAGAAGGCACAG
CCTGTTACTGTTGCTCATCATTTCGGTGCATATTTCGAAATGTTCAAGCGCGACAGAAGCAGACTTCACGATATATATGA
AAGAATGAATTACTGCCCTCTTGGTGCAGGCGCACTTGCAGGAACAACTTATCCATTAGACAGAGAACTTACTGCTTCTC
TTCTTGGTTTCTACGGCCCAACACTCAACAGTATGGATTCTGTTTCTGACAGAGATTATCTTATTGAATTCTTATCTGCA
TTATCAACTATCATGATGCATTTAAGCCGTTTCTCTGAGGAAATATGCATCTGGAATTCTAATGAATACAGATTCATAGA
ACTTGATGACGCTTTCAGTACAGGAAGCTCTATTATGCCTCAGAAGAAGAACCCTGATATTGCAGAGCTTGTAAGAGGTA
AGACAGGCAGAGTATATGGTGCTCTTATAAGTCTCCTTACAACAATGAAGGGTATTCCTCTTGCTTACAATAAAGATATG
CAGGAAGATAAGGAATTATCATTTGACGCATTTGACACAGCTAAAGGTTGCATCAGCCTTTTCAAGGGCATGATTGATAC
TATGAAATTCAACAACAAGAGAATGGAAGCTTCAGCAAAGAACGGCTTCACTAATGCTACTGATGCTGCTGACTATCTTG
TTAAGAAGGGGGTTCCTTTCAGAGAAGCCCACGGTATTGTCGGTCAGCTTGTTCTTATGTGCATTGAGAAGAATATCGCA
CTTGATGACCTTTCACTTGACGAATACAAGGCTGTAAGCCCTGTATTTGATGAAGATATCTACGAGGCAATCAGCCTTCA
GACTTGTGTAGATAAGAGACTTACTCTTGGAGCTCCTGGTCCAGAGGTTATGAATAAGGTTATTGCTATTTATGATAAAT
ATATGGAAGAGAATTAA

Upstream 100 bases:

>100_bases
TGATGAAATGAATGATTTTGATAATCTCGAATCTCCGGATTTCGAAGATGATACATCAGATTATAATTTAAAAGACAATG
AAACCAAGGAGGATTTATAA

Downstream 100 bases:

>100_bases
ATAGTATTTCGGGGTCGTACAGTCTGTGAGTCAAGCATTAGTGCCAACTTTAGGTAAGCTTACATGCCGTTGTCCCTAAC
GCTTAACTCACAGACACTAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKLWGGRFTKETNELVNNFNASISFDQKFYKQDIEGSIAHATMLGKQGIIPESESEQIVEGLKGILADIESGKLEITDEY
EDIHTFMEATLIERIGDAGKRLHTGRSRNDQVALDMRLFTRQEVLNTDAELKELMAVILRIMKENTHTFMPGFTHLQKAQ
PVTVAHHFGAYFEMFKRDRSRLHDIYERMNYCPLGAGALAGTTYPLDRELTASLLGFYGPTLNSMDSVSDRDYLIEFLSA
LSTIMMHLSRFSEEICIWNSNEYRFIELDDAFSTGSSIMPQKKNPDIAELVRGKTGRVYGALISLLTTMKGIPLAYNKDM
QEDKELSFDAFDTAKGCISLFKGMIDTMKFNNKRMEASAKNGFTNATDAADYLVKKGVPFREAHGIVGQLVLMCIEKNIA
LDDLSLDEYKAVSPVFDEDIYEAISLQTCVDKRLTLGAPGPEVMNKVIAIYDKYMEEN

Sequences:

>Translated_458_residues
MKLWGGRFTKETNELVNNFNASISFDQKFYKQDIEGSIAHATMLGKQGIIPESESEQIVEGLKGILADIESGKLEITDEY
EDIHTFMEATLIERIGDAGKRLHTGRSRNDQVALDMRLFTRQEVLNTDAELKELMAVILRIMKENTHTFMPGFTHLQKAQ
PVTVAHHFGAYFEMFKRDRSRLHDIYERMNYCPLGAGALAGTTYPLDRELTASLLGFYGPTLNSMDSVSDRDYLIEFLSA
LSTIMMHLSRFSEEICIWNSNEYRFIELDDAFSTGSSIMPQKKNPDIAELVRGKTGRVYGALISLLTTMKGIPLAYNKDM
QEDKELSFDAFDTAKGCISLFKGMIDTMKFNNKRMEASAKNGFTNATDAADYLVKKGVPFREAHGIVGQLVLMCIEKNIA
LDDLSLDEYKAVSPVFDEDIYEAISLQTCVDKRLTLGAPGPEVMNKVIAIYDKYMEEN
>Mature_458_residues
MKLWGGRFTKETNELVNNFNASISFDQKFYKQDIEGSIAHATMLGKQGIIPESESEQIVEGLKGILADIESGKLEITDEY
EDIHTFMEATLIERIGDAGKRLHTGRSRNDQVALDMRLFTRQEVLNTDAELKELMAVILRIMKENTHTFMPGFTHLQKAQ
PVTVAHHFGAYFEMFKRDRSRLHDIYERMNYCPLGAGALAGTTYPLDRELTASLLGFYGPTLNSMDSVSDRDYLIEFLSA
LSTIMMHLSRFSEEICIWNSNEYRFIELDDAFSTGSSIMPQKKNPDIAELVRGKTGRVYGALISLLTTMKGIPLAYNKDM
QEDKELSFDAFDTAKGCISLFKGMIDTMKFNNKRMEASAKNGFTNATDAADYLVKKGVPFREAHGIVGQLVLMCIEKNIA
LDDLSLDEYKAVSPVFDEDIYEAISLQTCVDKRLTLGAPGPEVMNKVIAIYDKYMEEN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=419, Percent_Identity=42.9594272076372, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=419, Percent_Identity=42.9594272076372, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=419, Percent_Identity=40.8114558472554, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI68303547, Length=419, Percent_Identity=40.3341288782816, Blast_Score=328, Evalue=7e-90,
Organism=Escherichia coli, GI1790398, Length=450, Percent_Identity=48, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=43.5267857142857, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=419, Percent_Identity=40.3341288782816, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI78706858, Length=419, Percent_Identity=40.3341288782816, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_EUBE2 (C4Z0V2)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930662.1
- ProteinModelPortal:   C4Z0V2
- GeneID:   7957759
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01217
- OMA:   MAEDLIF
- ProtClustDB:   CLSK2541005
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51661; Mature: 51661

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFTKETNELVNNFNASISFDQKFYKQDIEGSIAHATMLGKQGIIPESESEQIVE
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHH
GLKGILADIESGKLEITDEYEDIHTFMEATLIERIGDAGKRLHTGRSRNDQVALDMRLFT
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
RQEVLNTDAELKELMAVILRIMKENTHTFMPGFTHLQKAQPVTVAHHFGAYFEMFKRDRS
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RLHDIYERMNYCPLGAGALAGTTYPLDRELTASLLGFYGPTLNSMDSVSDRDYLIEFLSA
HHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
LSTIMMHLSRFSEEICIWNSNEYRFIELDDAFSTGSSIMPQKKNPDIAELVRGKTGRVYG
HHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHH
ALISLLTTMKGIPLAYNKDMQEDKELSFDAFDTAKGCISLFKGMIDTMKFNNKRMEASAK
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
NGFTNATDAADYLVKKGVPFREAHGIVGQLVLMCIEKNIALDDLSLDEYKAVSPVFDEDI
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHH
YEAISLQTCVDKRLTLGAPGPEVMNKVIAIYDKYMEEN
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLWGGRFTKETNELVNNFNASISFDQKFYKQDIEGSIAHATMLGKQGIIPESESEQIVE
CCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHH
GLKGILADIESGKLEITDEYEDIHTFMEATLIERIGDAGKRLHTGRSRNDQVALDMRLFT
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
RQEVLNTDAELKELMAVILRIMKENTHTFMPGFTHLQKAQPVTVAHHFGAYFEMFKRDRS
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
RLHDIYERMNYCPLGAGALAGTTYPLDRELTASLLGFYGPTLNSMDSVSDRDYLIEFLSA
HHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
LSTIMMHLSRFSEEICIWNSNEYRFIELDDAFSTGSSIMPQKKNPDIAELVRGKTGRVYG
HHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHH
ALISLLTTMKGIPLAYNKDMQEDKELSFDAFDTAKGCISLFKGMIDTMKFNNKRMEASAK
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
NGFTNATDAADYLVKKGVPFREAHGIVGQLVLMCIEKNIALDDLSLDEYKAVSPVFDEDI
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHH
YEAISLQTCVDKRLTLGAPGPEVMNKVIAIYDKYMEEN
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA