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The map label for this gene is hisG

Identifier: 238916954

GI number: 238916954

Start: 1036441

End: 1037091

Strand: Reverse

Name: hisG

Synonym: EUBELI_01023

Alternate gene names: 238916954

Gene position: 1037091-1036441 (Counterclockwise)

Preceding gene: 238916955

Following gene: 238916953

Centisome position: 48.37

GC content: 37.63

Gene sequence:

>651_bases
ATGAGATATATAACTATTGCATTAGCAAAAGGCCGTCTTGCAAAGAAGGCAATGGAGATATTTGAACAGATTGGTATTCC
TTGCGAAGAGATGAAGGATGAAAAGACAAGAAAGCTTATCTTCACTAATGAAGAATTAGGATTCCGTTTCTTTTTATCAA
AGCCATCTGATGTTCCTACATATGTAGAATATGGTGCGGCCGATATCGGTATTGTAGGTAAGGATACAATTCTTGAGGAA
GGAAGAAGTCTTTATGAAGTATATGACCTTCAGATGGGCAAATGCAGAATGTGTGTATGCGGTCCTGAATCAGCAAGAGA
AAAGTTACAGCATCATGAGCTTATAAGAGTTGCTTCTAAGTATCCTAACATTGCAAAGGATTATTTTAATAATATAAAGC
ACCAGACTGTAGAGATTATCAAGCTTAACGGTTCTGTCGAGTTAGCACCTATTGTAGGTCTTGCAGAGGTTATCGTTGAT
ATCGTTGAGACAGGTGCAACTTTAAGAGAAAATGGTCTTGAAGTGCTCGAAGAGGTGTGTCCTCTTTCTGCGAGAATGGT
TGTAAACCAGGTAAGCATGAAGATGGAGCAGGAGCGAATTAATAAACTTATTAATGATGTTAAGAAATATATAGAAACAC
AGGGCAGATAA

Upstream 100 bases:

>100_bases
TTGATGATGAATACACTTCTGATTCAACAATAAGAGTTATTGATGAATCAGGAAAAAATGAAAGAGCAGCTGTAAAAAGC
CTTTTAGGAGGTACATTTTA

Downstream 100 bases:

>100_bases
CAAGCATTAAAACAAGGAGGAATACAATGCGTATCGTTGAATTAACAGATGAAAGTAAGAATAATATTTTAGAGAATCTT
TTAAAGAGAAGTCCTAACAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRYITIALAKGRLAKKAMEIFEQIGIPCEEMKDEKTRKLIFTNEELGFRFFLSKPSDVPTYVEYGAADIGIVGKDTILEE
GRSLYEVYDLQMGKCRMCVCGPESAREKLQHHELIRVASKYPNIAKDYFNNIKHQTVEIIKLNGSVELAPIVGLAEVIVD
IVETGATLRENGLEVLEEVCPLSARMVVNQVSMKMEQERINKLINDVKKYIETQGR

Sequences:

>Translated_216_residues
MRYITIALAKGRLAKKAMEIFEQIGIPCEEMKDEKTRKLIFTNEELGFRFFLSKPSDVPTYVEYGAADIGIVGKDTILEE
GRSLYEVYDLQMGKCRMCVCGPESAREKLQHHELIRVASKYPNIAKDYFNNIKHQTVEIIKLNGSVELAPIVGLAEVIVD
IVETGATLRENGLEVLEEVCPLSARMVVNQVSMKMEQERINKLINDVKKYIETQGR
>Mature_216_residues
MRYITIALAKGRLAKKAMEIFEQIGIPCEEMKDEKTRKLIFTNEELGFRFFLSKPSDVPTYVEYGAADIGIVGKDTILEE
GRSLYEVYDLQMGKCRMCVCGPESAREKLQHHELIRVASKYPNIAKDYFNNIKHQTVEIIKLNGSVELAPIVGLAEVIVD
IVETGATLRENGLEVLEEVCPLSARMVVNQVSMKMEQERINKLINDVKKYIETQGR

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=223, Percent_Identity=29.5964125560538, Blast_Score=87, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.2702702702703, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_EUBE2 (C4Z0B1)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930471.1
- GeneID:   7958437
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01023
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24531; Mature: 24531

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYITIALAKGRLAKKAMEIFEQIGIPCEEMKDEKTRKLIFTNEELGFRFFLSKPSDVPT
CCEEEEEECCCHHHHHHHHHHHHHCCCHHHHCCHHHHEEEEECCCCCEEEEECCCCCCCH
YVEYGAADIGIVGKDTILEEGRSLYEVYDLQMGKCRMCVCGPESAREKLQHHELIRVASK
HHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
YPNIAKDYFNNIKHQTVEIIKLNGSVELAPIVGLAEVIVDIVETGATLRENGLEVLEEVC
CCCHHHHHHHHHHHHEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
PLSARMVVNQVSMKMEQERINKLINDVKKYIETQGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRYITIALAKGRLAKKAMEIFEQIGIPCEEMKDEKTRKLIFTNEELGFRFFLSKPSDVPT
CCEEEEEECCCHHHHHHHHHHHHHCCCHHHHCCHHHHEEEEECCCCCEEEEECCCCCCCH
YVEYGAADIGIVGKDTILEEGRSLYEVYDLQMGKCRMCVCGPESAREKLQHHELIRVASK
HHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
YPNIAKDYFNNIKHQTVEIIKLNGSVELAPIVGLAEVIVDIVETGATLRENGLEVLEEVC
CCCHHHHHHHHHHHHEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
PLSARMVVNQVSMKMEQERINKLINDVKKYIETQGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA