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The map label for this gene is hisD [H]

Identifier: 238916953

GI number: 238916953

Start: 1035122

End: 1036414

Strand: Reverse

Name: hisD [H]

Synonym: EUBELI_01022

Alternate gene names: 238916953

Gene position: 1036414-1035122 (Counterclockwise)

Preceding gene: 238916954

Following gene: 238916952

Centisome position: 48.34

GC content: 37.82

Gene sequence:

>1293_bases
ATGCGTATCGTTGAATTAACAGATGAAAGTAAGAATAATATTTTAGAGAATCTTTTAAAGAGAAGTCCTAACAGCTATGG
AAAGTTTGAATCAGCCGTTGCTGAGATTCTTCTTAATATCAAGACAAGAGGTGATGAGGCTTTATTTGAATATACTAAGA
ATTTTGATAAGGCTGATATCAATGCTGACAATATTGTCGTAACAGAGGCAGAGATTGAAGAAGCATATTCTTTAGTTGAC
CCTGAGCTTATTGATGTTATAAGAAAGGCTATCGTTAATATTCGTTCTTTCCATGAGAAGCAGAAACAGTACAGCTGGTT
TGATTCTAAGCCGGATGGAACTATATTAGGTCAGAAGGTTACTGCACTTGCAAGAGTAGGTGTGTATGTACCTGGTGGAA
AGGCTGCCTATCCTTCATCAGTTCTTATGAATGTTCTTCCGGCAAAGGTTGCAGGCGTTGATCAGATTATAATGTGTACT
CCACCTGATAAAGAAGGAAAGGTATATCCTACAACACTTGTTGCAGCTAAAGAAGCTGGTGTTGATGTTATATACAAGGC
TGGTGGAGCGCAGGCTGTTGCAGCTATGGCATATGGTACAAAATCAATTCCTAAGGTTGATAAGATATGTGGACCTGGTA
ACATATATGTTGCCCTTGCTAAAAAGGCCGTATTTGGTTATGTAAGCATTGATTCTGTTGCTGGTCCTAGTGAGATTCTT
GTAATTGCTGATGAGACTGCTAATCCTCGTTACGTTGCAGCAGATCTTTTATCTCAGGCTGAACATGATGAGATGGCATC
TGCAATTCTTGTAACTACAAGTGAAGACCTTGCACATAAGGTATCTGCAGAAGTTGATAAGTTTGTAGCTGAATTATCAA
GAAAGGAAATTATCCAGAAATCACTTGATAATTACGGATATATTCTTGTTGCTAAGGATATTGATGAGGCTGTAGATGTT
GCTAACGAGATTGCATCAGAGCATATGGAAATCGTTACAAAGAATCCTTTTGATGTTATGACTAAGGTTAAGAACGCAGG
TGCTATCTTCCTTGGAGAATACAGTTCAGAGCCTCTTGGTGATTACTTTGCAGGTCCTAACCACGTTCTTCCTACTAATG
GAACAGCTAAGTTCTTCTCACCTTTAAGTGTTGATGACTTCATTAAGAAATCGAGCATTATTTCATATTCTAGAAATGCT
CTTGAAGCTATCCACACTGATATTGAGAAATTTGCTACAGCAGAGCATCTTACAGCTCATGCTAATTCAATTAAGGTAAG
ATTTGAAAATTAA

Upstream 100 bases:

>100_bases
TGAAGATGGAGCAGGAGCGAATTAATAAACTTATTAATGATGTTAAGAAATATATAGAAACACAGGGCAGATAACAAGCA
TTAAAACAAGGAGGAATACA

Downstream 100 bases:

>100_bases
TTAGCGCACTGGCGCGGAAACGGGGATTATATGGCTGTATCTGAAATCAGACAGGCAACTGTAAAAAGAAAAACGAGTGA
AACTGATATTGCTTTATTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MRIVELTDESKNNILENLLKRSPNSYGKFESAVAEILLNIKTRGDEALFEYTKNFDKADINADNIVVTEAEIEEAYSLVD
PELIDVIRKAIVNIRSFHEKQKQYSWFDSKPDGTILGQKVTALARVGVYVPGGKAAYPSSVLMNVLPAKVAGVDQIIMCT
PPDKEGKVYPTTLVAAKEAGVDVIYKAGGAQAVAAMAYGTKSIPKVDKICGPGNIYVALAKKAVFGYVSIDSVAGPSEIL
VIADETANPRYVAADLLSQAEHDEMASAILVTTSEDLAHKVSAEVDKFVAELSRKEIIQKSLDNYGYILVAKDIDEAVDV
ANEIASEHMEIVTKNPFDVMTKVKNAGAIFLGEYSSEPLGDYFAGPNHVLPTNGTAKFFSPLSVDDFIKKSSIISYSRNA
LEAIHTDIEKFATAEHLTAHANSIKVRFEN

Sequences:

>Translated_430_residues
MRIVELTDESKNNILENLLKRSPNSYGKFESAVAEILLNIKTRGDEALFEYTKNFDKADINADNIVVTEAEIEEAYSLVD
PELIDVIRKAIVNIRSFHEKQKQYSWFDSKPDGTILGQKVTALARVGVYVPGGKAAYPSSVLMNVLPAKVAGVDQIIMCT
PPDKEGKVYPTTLVAAKEAGVDVIYKAGGAQAVAAMAYGTKSIPKVDKICGPGNIYVALAKKAVFGYVSIDSVAGPSEIL
VIADETANPRYVAADLLSQAEHDEMASAILVTTSEDLAHKVSAEVDKFVAELSRKEIIQKSLDNYGYILVAKDIDEAVDV
ANEIASEHMEIVTKNPFDVMTKVKNAGAIFLGEYSSEPLGDYFAGPNHVLPTNGTAKFFSPLSVDDFIKKSSIISYSRNA
LEAIHTDIEKFATAEHLTAHANSIKVRFEN
>Mature_430_residues
MRIVELTDESKNNILENLLKRSPNSYGKFESAVAEILLNIKTRGDEALFEYTKNFDKADINADNIVVTEAEIEEAYSLVD
PELIDVIRKAIVNIRSFHEKQKQYSWFDSKPDGTILGQKVTALARVGVYVPGGKAAYPSSVLMNVLPAKVAGVDQIIMCT
PPDKEGKVYPTTLVAAKEAGVDVIYKAGGAQAVAAMAYGTKSIPKVDKICGPGNIYVALAKKAVFGYVSIDSVAGPSEIL
VIADETANPRYVAADLLSQAEHDEMASAILVTTSEDLAHKVSAEVDKFVAELSRKEIIQKSLDNYGYILVAKDIDEAVDV
ANEIASEHMEIVTKNPFDVMTKVKNAGAIFLGEYSSEPLGDYFAGPNHVLPTNGTAKFFSPLSVDDFIKKSSIISYSRNA
LEAIHTDIEKFATAEHLTAHANSIKVRFEN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=399, Percent_Identity=41.8546365914787, Blast_Score=303, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=37.1158392434988, Blast_Score=250, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46760; Mature: 46760

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVELTDESKNNILENLLKRSPNSYGKFESAVAEILLNIKTRGDEALFEYTKNFDKADI
CEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NADNIVVTEAEIEEAYSLVDPELIDVIRKAIVNIRSFHEKQKQYSWFDSKPDGTILGQKV
CCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
TALARVGVYVPGGKAAYPSSVLMNVLPAKVAGVDQIIMCTPPDKEGKVYPTTLVAAKEAG
HHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCEEEEEHHCC
VDVIYKAGGAQAVAAMAYGTKSIPKVDKICGPGNIYVALAKKAVFGYVSIDSVAGPSEIL
CEEEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEHHHHEEEEEECCCCCCCEEE
VIADETANPRYVAADLLSQAEHDEMASAILVTTSEDLAHKVSAEVDKFVAELSRKEIIQK
EEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDNYGYILVAKDIDEAVDVANEIASEHMEIVTKNPFDVMTKVKNAGAIFLGEYSSEPLG
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCCC
DYFAGPNHVLPTNGTAKFFSPLSVDDFIKKSSIISYSRNALEAIHTDIEKFATAEHLTAH
HHCCCCCCEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ANSIKVRFEN
CCEEEEEECC
>Mature Secondary Structure
MRIVELTDESKNNILENLLKRSPNSYGKFESAVAEILLNIKTRGDEALFEYTKNFDKADI
CEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NADNIVVTEAEIEEAYSLVDPELIDVIRKAIVNIRSFHEKQKQYSWFDSKPDGTILGQKV
CCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
TALARVGVYVPGGKAAYPSSVLMNVLPAKVAGVDQIIMCTPPDKEGKVYPTTLVAAKEAG
HHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCEEEEEHHCC
VDVIYKAGGAQAVAAMAYGTKSIPKVDKICGPGNIYVALAKKAVFGYVSIDSVAGPSEIL
CEEEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEHHHHEEEEEECCCCCCCEEE
VIADETANPRYVAADLLSQAEHDEMASAILVTTSEDLAHKVSAEVDKFVAELSRKEIIQK
EEEECCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDNYGYILVAKDIDEAVDVANEIASEHMEIVTKNPFDVMTKVKNAGAIFLGEYSSEPLG
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCCC
DYFAGPNHVLPTNGTAKFFSPLSVDDFIKKSSIISYSRNALEAIHTDIEKFATAEHLTAH
HHCCCCCCEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ANSIKVRFEN
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]