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The map label for this gene is proA

Identifier: 238916918

GI number: 238916918

Start: 1002043

End: 1003290

Strand: Direct

Name: proA

Synonym: EUBELI_00987

Alternate gene names: 238916918

Gene position: 1002043-1003290 (Clockwise)

Preceding gene: 238916917

Following gene: 238916919

Centisome position: 46.73

GC content: 37.74

Gene sequence:

>1248_bases
ATGGAATCACTTGAACAGATTGGAATTAAGGCTAAGAAGGCATCAAGATATCTTGCTAAGCTTGGAATAGATGAGAAGAA
TAAGGCACTTGAAGCGGTTGCTGATGCACTTACAGCTAATGCAGAGAGTATAATTGCAGCCAATGAAAAAGACCTTGTTA
ATGCCAAAGCCAACGGAATGAAGCCTGCTCTTATTGACAGACTTACGCTTGATATTAAGAGAATCAATGCAATGGCAGAT
GGAATAAGAGTTCTTACAGGTCTTGAAGATCCGGTTGGCGAAGTAACAGGCATGAAGAAAAGACCTAACGGACTTGTTAT
CGGAACGAAGAGAGTACCTCTTGGCGTTGTTGCAATTATATATGAGTCAAGACCTAATGTTACTGCTGATGCATTCGGAC
TTACTTTCAAGTCTGGCAATGCCTGCATCTTAAGAGGCGGAAGTGATTCTATTAATTCTAATATTGCTATTGCAGATGTT
ATTGCAAATGCACTTTCTGACAACGGAATTAATCCTGATGTTATTAATCTTATAAAAGATACAGACAGAGCACTTGTTAA
CCAGCTTATGAAGATGAATGATTACATTGATGTAATTATTCCAAGAGGTGGGGCAGGGCTTATTAAGAATGTTGTCAACA
ACAGTACAGTACCTGTAATTGAAACTGGTACAGGGAACTGTCATGTATATGTTGATGAATATGCTGATATTGATATGGCT
GTCAAAGTTATATATAATGCCAAGACTTCAAGAATTGGAGTATGTAATGCGTGTGAATCATTGGTTATTCACAAGGCTGT
TGCAAAGCAGGCAATTCCACTTATTGTAAATGCACTTAAAGAAAAGAATGTTGAAGTGCGTGGTGATGAATATGCAATGC
AGTGTGATTCAAGAATTGTTCCGGCAAGTGATGATGACTGGGGAATGGAATATCTTGATTATATTATATCTGTTAAGACT
GTTGACTCTGTTGACGAAGCAATAGAACATATTAATACATATAACACAGGCCATTCAGAGTCAATAATTACTAAAGATTA
CAATAATGCCAACAGATTTCTTGATGAAATAGATGCTGCATGTGTATATGTAAATGCTTCTACAAGATTTTCTGATGGGT
TTGAATTCGGATTTGGTGCTGAGATAGGAATAAGCACACAGAAGCTTCACGCAAGAGGACCTATGGGACTTAAAGCGCTT
ACAACGACTAAGTATGTCATATACGGAGAGGGGCAGATAAGACAGTAA

Upstream 100 bases:

>100_bases
CTTTTGATTTCCAGCTTTTAGAGAGTATTCCTTATGAGGAACATGATTTAAAACCGGATTATATTATTACACAGACACAG
TTTATAAGGAGGGAGAATTG

Downstream 100 bases:

>100_bases
GCTGTTTTATGGGTATTAGGTGTTTTTATGATTAGAAGAGATTTTGATTTAGAAGAAATGAAGTATTTTCTTCATCTTGT
CGGACAGAGTACAGATGATT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGMKPALIDRLTLDIKRINAMAD
GIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAIIYESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADV
IANALSDNGINPDVINLIKDTDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMA
VKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIVPASDDDWGMEYLDYIISVKT
VDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAACVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKAL
TTTKYVIYGEGQIRQ

Sequences:

>Translated_415_residues
MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGMKPALIDRLTLDIKRINAMAD
GIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAIIYESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADV
IANALSDNGINPDVINLIKDTDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMA
VKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIVPASDDDWGMEYLDYIISVKT
VDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAACVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKAL
TTTKYVIYGEGQIRQ
>Mature_415_residues
MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGMKPALIDRLTLDIKRINAMAD
GIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAIIYESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADV
IANALSDNGINPDVINLIKDTDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMA
VKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIVPASDDDWGMEYLDYIISVKT
VDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAACVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKAL
TTTKYVIYGEGQIRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=417, Percent_Identity=35.0119904076739, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI62912457, Length=417, Percent_Identity=35.0119904076739, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=46.2650602409639, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=35.4916067146283, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=35.4916067146283, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=435, Percent_Identity=37.0114942528736, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=34.5679012345679, Blast_Score=251, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_EUBE2 (C4Z075)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930435.1
- ProteinModelPortal:   C4Z075
- GeneID:   7957848
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_00987
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44829; Mature: 44829

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGM
CCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHEEECCCCHHCCCCCCCC
KPALIDRLTLDIKRINAMADGIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAII
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEE
YESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADVIANALSDNGINPDVINLIKD
EECCCCCEEEHEEEEEECCCEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHH
TDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCCEE
VKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIV
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHEECCCCCC
PASDDDWGMEYLDYIISVKTVDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCE
CVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKALTTTKYVIYGEGQIRQ
EEEEECCCCCCCCCCCCCCCEECCCHHHEECCCCCCEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MESLEQIGIKAKKASRYLAKLGIDEKNKALEAVADALTANAESIIAANEKDLVNAKANGM
CCCHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHEEECCCCHHCCCCCCCC
KPALIDRLTLDIKRINAMADGIRVLTGLEDPVGEVTGMKKRPNGLVIGTKRVPLGVVAII
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEE
YESRPNVTADAFGLTFKSGNACILRGGSDSINSNIAIADVIANALSDNGINPDVINLIKD
EECCCCCEEEHEEEEEECCCEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHH
TDRALVNQLMKMNDYIDVIIPRGGAGLIKNVVNNSTVPVIETGTGNCHVYVDEYADIDMA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCCEE
VKVIYNAKTSRIGVCNACESLVIHKAVAKQAIPLIVNALKEKNVEVRGDEYAMQCDSRIV
EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHEECCCCCC
PASDDDWGMEYLDYIISVKTVDSVDEAIEHINTYNTGHSESIITKDYNNANRFLDEIDAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHCCCE
CVYVNASTRFSDGFEFGFGAEIGISTQKLHARGPMGLKALTTTKYVIYGEGQIRQ
EEEEECCCCCCCCCCCCCCCEECCCHHHEECCCCCCEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA