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The map label for this gene is ilvD [H]

Identifier: 238916700

GI number: 238916700

Start: 771836

End: 773509

Strand: Direct

Name: ilvD [H]

Synonym: EUBELI_00762

Alternate gene names: 238916700

Gene position: 771836-773509 (Clockwise)

Preceding gene: 238916699

Following gene: 238916701

Centisome position: 36.0

GC content: 42.41

Gene sequence:

>1674_bases
ATGATAAGTGATAACGCCAGAAGTGGTATGCAGCAGGCACCTGCACGAAGCCTTTTTAATGCACTTGGCTTCACAGCAGA
AGAGATGAAGAAACCTATGATTGGTATTGTAAGCTCTTATAATGAGATTGTACCAGGTCATATGAATATTGATAAGATTG
TCAATGCAGTTAAATTAGGAGTTGCTGAGGCAGGCGGTGTGCCTGTAGTATTCCCTGCTATTGCAGTATGCGATGGTATT
GCAATGGGACATGTCGGAATGAAATATTCTTTAGTAACAAGAGATTTAATTGCAGATTCAACAGAGTGTATGGCAATTGC
ACATCAGTTTGACGGACTTGTAATGGTTCCTAACTGTGATAAGAATGTTCCAGGACTTTTAATGGCAGCAGCAAGACTTA
ATCTTCCAACTGTATTCGTATCAGGCGGACCAATGCTTGCAGGTCATGTTAAGGGTAAGAAGAGAAGCCTTTCTTCAATG
TTTGAGGCTGTTGGTTCATATGCAGCAGGAACAATGACAGAGGAAGATGTACTTGAGTTTGAGGAAAAGGTATGCCCAAC
ATGTGGTTCATGTTCAGGCATGTACACAGCCAATTCAATGAACTGCCTTACAGAGGCACTTGGTATGGGACTTCGCGGCA
ATGGTACAATTCCAGCCGTATATTCAGAGAGAATCAAGCTTGCAAAGCACGCAGGCATGGCTGTTATGGATATGGTTAAT
AAGGGAATCACAGCAAGAGATATCATCACTAAGGATTCTATTATGAATGCCCTTACAGTAGATATGGCACTTGGATGTTC
TACTAATTCAATGCTTCACCTTCCAGCTATTGCACATGAGATAGGATTTGATTTTGATATCAAATTCGCTAACCCAATAA
GTGAAAAGACTCCTAATCTCTGCCACCTTGCACCAGCAGGTCCAACATACATGGAAGACCTTAATGAAGCAGGCGGTGTA
TATGCAGTTATGAAAGAGCTTGCAGATATCGGACTTCTTAATACAGACTGCCTGACAGTTTCAGGAAAGACAATCGGCGA
GTGCATAGCAACAGCATACAACCGTGATCCTGAAGTCATAAGAACAGTTGATAATGCATACAGTAAGACAGGTGGTCTTG
CAGTTCTTTCAGGAAATCTTGCACCAGACGGATCAGTAGTCAAGCGTTCAGCAGTTGTTCCAGAGATGCTTGTACATGAA
GGCCCGGCAAGAGTATTTGATTCAGAAGAAGATGCAATTGCTGCTATTAAGGGTGGTAAGATAGTTGAAGGTGATGTAGT
TGTTATCCGTTACGAAGGTCCTAAGGGTGGTCCTGGTATGAGAGAAATGCTTAATCCTACATCAGCTATTGCAGGTATGG
GACTTGGCTCATCAGTTGCTCTTATTACAGATGGACGATTCTCAGGTGCAAGCCGTGGAGCTTCTATTGGTCATGTATCA
CCAGAGGCTGCTGTTGGCGGACCTATTGCTTTAGTTGAAGAAGGAGATATCATCAGCATTGATATTCCGGGACTTAAACT
TGAACTTAAGGTTTCAGATGAAGAGCTTGCTGCAAGAAAGGCTAAGTGGCAGCCAAGAGAACCTAAGGTAACAACAGGAT
ACTTAAAGAGATATGCTTCACTCGTTACATCAGGAAACAGAGGAGCTATTCTTAAAAGTTCAGCAGATGAGTAA

Upstream 100 bases:

>100_bases
ATGTCAGAAGGATGCACACTTGTAGGAACTGATAAGATGGGCGACTTAATCGCAGAGAGAGTTTAATACATTTAAATAAT
ACATATTAAGGAGATAAGCT

Downstream 100 bases:

>100_bases
TATTTAATATAATTATAAAAAGACATTAAAGAGAAATCAGGAGAAGATAAATGAAGTTAAATGGTTCAGAGATAATTGTT
GAATGCTTGAAAGAACAGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLGVAEAGGVPVVFPAIAVCDGI
AMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCDKNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSM
FEAVGSYAAGTMTEEDVLEFEEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVN
KGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNLCHLAPAGPTYMEDLNEAGGV
YAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVIRTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHE
GPARVFDSEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVS
PEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYASLVTSGNRGAILKSSADE

Sequences:

>Translated_557_residues
MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLGVAEAGGVPVVFPAIAVCDGI
AMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCDKNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSM
FEAVGSYAAGTMTEEDVLEFEEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVN
KGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNLCHLAPAGPTYMEDLNEAGGV
YAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVIRTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHE
GPARVFDSEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVS
PEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYASLVTSGNRGAILKSSADE
>Mature_557_residues
MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLGVAEAGGVPVVFPAIAVCDGI
AMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCDKNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSM
FEAVGSYAAGTMTEEDVLEFEEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVN
KGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNLCHLAPAGPTYMEDLNEAGGV
YAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVIRTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHE
GPARVFDSEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVS
PEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYASLVTSGNRGAILKSSADE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=601, Percent_Identity=44.5923460898502, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786464, Length=503, Percent_Identity=35.1888667992048, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI2367371, Length=522, Percent_Identity=33.9080459770115, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1788157, Length=522, Percent_Identity=32.9501915708812, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=40.5454545454545, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58343; Mature: 58343

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLG
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VAEAGGVPVVFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCD
HHCCCCCCCHHHHHHHHCCHHCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCEEECCCCC
KNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSMFEAVGSYAAGTMTEEDVLEF
CCCCHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVN
HHHHCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
KGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNL
CCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHCCCEEEEECCCHHHCCCCE
CHLAPAGPTYMEDLNEAGGVYAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVI
EEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHH
RTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHEGPARVFDSEEDAIAAIKGGK
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCE
IVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVS
EEECCEEEEEECCCCCCCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
PEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYAS
CCCCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LVTSGNRGAILKSSADE
HHCCCCCCEEECCCCCC
>Mature Secondary Structure
MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLG
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VAEAGGVPVVFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCD
HHCCCCCCCHHHHHHHHCCHHCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCEEECCCCC
KNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSMFEAVGSYAAGTMTEEDVLEF
CCCCHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVN
HHHHCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
KGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNL
CCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHCCCEEEEECCCHHHCCCCE
CHLAPAGPTYMEDLNEAGGVYAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVI
EEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHH
RTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHEGPARVFDSEEDAIAAIKGGK
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEEECCCE
IVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVS
EEECCEEEEEECCCCCCCCHHHHCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
PEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYAS
CCCCCCCCEEEEECCCEEEEECCCEEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LVTSGNRGAILKSSADE
HHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA