| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is mrcA [H]
Identifier: 238896864
GI number: 238896864
Start: 4826395
End: 4828959
Strand: Direct
Name: mrcA [H]
Synonym: KP1_5097
Alternate gene names: 238896864
Gene position: 4826395-4828959 (Clockwise)
Preceding gene: 238896851
Following gene: 238896866
Centisome position: 91.96
GC content: 59.26
Gene sequence:
>2565_bases GTGAAGTTCGTAAAGTATCTATTGATCCTTGCAGTCTGTTGCGTACTGCTGGGAGCAGGCTCGATTTTTGGCCTCTACAA ATACATAGAGCCGCAACTCCCCGACGTCGCAACCCTGAAGGATGTGCGTTTGCAGATCCCGATGCAGGTCTATAGCGCCG ACGGTGAGCTTATTGCGCAGTACGGCGAAAAGCGCCGTATCCCTGTGACGTTGCAGCAAATTCCCCCCGAGCTGGTGAAA GCGTTTATCGCCACCGAAGACAGCCGCTTCTATGAGCACCATGGCGTCGATCCGGTAGGTATTTTCCGCGCCGCCAGCGT GGCGATGTTTTCAGGCCACGCCTCCCAGGGCGCCAGCACCATCACCCAGCAGTTAGCGCGTAACTTCTTTCTCAGCCCCG AGAAGACGTTGATGCGTAAGATTAAAGAGGCCTTTCTGGCCATCCGCATCGAGCAGTTGCTGAATAAAGATGAAATCCTT GAGCTGTATCTGAACAAGATCTACCTCGGCTACCGCGCCTATGGCGTCGGCGCCGCGGCGCAGGTCTATTTTGGCAAACC TATCGACCAACTGACCCTGAGTGAGATGGCGGTGATTGCCGGTCTGCCGAAAGCGCCTTCCACTTTTAACCCGCTCTATT CGATGGATCGCGCGACCGCCCGTCGCAACGTGGTGCTGTCGCGTATGCTGAGCGAAGGATACATCACCCAGGCGCAATAC GATGAGGCGCGCAGCGAACCCATCGACGCCAGCTATCACGCGCCGAAAATCGCCTTCTCCGCCCCTTACCTGAGTGAAAT GGTGCGCCAGGAGATGGTGAATCGCTACGGCGAGCAGGCCTACGAAGATGGTTATCGGGTCTACACCACCATTACCCGTA AAAACCAGCAGGCGGCCCAGCAGGCGGTACGCAATAACGTGCTGGATTACGATATGCGTCACGGCTACCGCGGCCCGGCC AGCGTACTGTGGAAAGTCGGCGAAACGCCGTGGGAGACGAAGAAGATCGTCGATTCGCTGAAGCGTCAGTCTGGCTACGG TCCGCTTTTCCCGGCGGTGGTCACCTCCGCGAATGCCCAGGAGGCTGTCGCGCTGTTGGCTAACGGCGACTCCGTTTCGC TGACGATGGAGGGCGTGCGCTGGGCCCGTCGCTTTATCTCTGATACGCAGCAAGGGGCGACCCCGCGTAAAGTCAACGAC GTTGTGCAGGCCGGGCAGCAGATCTGGGTACGCAAGGTGGGTGACAGCTGGTGGCTGTCCCAGCTCCCGGACGTCAACTC AGCGCTGGTCTCCATTAACCCGCAAAACGGCGCGATTATTGCCCTTGTCGGCGGGTTTGACTTTAACCAGAGCAAATTCA ACCGCGCCACCCAGGCGCTGCGCCAGGTCGGCTCCAACATTAAACCGTTCCTCTATACCGCCGCGATGGATAAAGGCTTA ACGCTGGCAAGTATGCTCAACGATGTGCCGATCTCGCGCTGGGATGCGGGCGCAGGTTCCGACTGGCGGCCGAAGAACTC GCCGCCGCAGTATGCCGGTCCGATTCGTTTACGCCAGGGCCTGGGGCAGTCGAAAAACGTGGTGATGGTGCGCGCTATGC GCGCCATGGGCGTAGACTACGCCGCCGAGTATCTGCAGCGCTTTGGCTTCCCGGCGCAGAACATTGTCCACACGGAATCG TTGGCGCTGGGCTCAGCCTCCTTTACGCCCCTGCAGGTCGCTCGCGGTTATTCGGTGATGGCCAACGGCGGCTTCCTGGT CAATCCTTTCTTTATCATTAAGATTGAGAACGATCAGGGCGGGGTCCTCTTCGAGGAGCGTCCGAAAATTGCCTGTCCGC AGTGTGATTTACCGGTAATTTACGGCGATACGCCAAAATCCAACGTGCTGGAAAACAAGGATGTGGAAGATGTCGCCACC TCCGCGGAACCGCAGAATGGCAACGTGCCTCCGCAGCCGCAGCCGCAGCTGGAGCAGGCCAACCAGTCGCTGGTCGCGCA GAGCGGCGCACAGGAATACGCGCCGCATGTGATTAACACACCGCTGGCCTTCCTGATCAAGAGCGCGCTGAACAGCAACA TCTTTGGCGAGCCGGGCTGGATGGGCACCGGCTGGCGCGCCGGACGCGATCTGCAGCGGCATGACATCGGTGGGAAAACC GGGACCACCAACAGCTCGAAGGACGCCTGGTTCTCAGGCTACGGACCGGGCGTGGTGACCTCGGTTTGGATCGGCTTTGA CGATCATCGTCGCGATCTTGGCCGGACCACCGCCTCCGGAGCGATTAAAGATCAGATCTCTGGCTATGAAGGCGGTGCCA AAAGCGCCCAGCCGGCCTGGGATAGCTTTATGAAGAGCGTGCTGGAAGGCGTTCCGGAAGAACCGTTAACTCCGCCGCCG GGTATCGTCACGGTGAATATCGACCGTAGCACTGGTCAGTTGGCGAACGGGGGCAATAGCCGGGCGGAGTACTTTATTGA AGGAACCCAGCCCACCCAGCAGGCAGTCCGTGAGGTTGGCACCACCCTGACTGACGGCGGCGGTGAAACCCACGAATTGT TCTGA
Upstream 100 bases:
>100_bases CGGCAAAACTGCCCGGCTATATCAATGCACCTGGCTTGCCTTTATACTACCGCGCGTTTGTTTATAAACTGCCCAAATAA AACTAAATGGGAAAACACCG
Downstream 100 bases:
>100_bases CAAAAAAAGCGCCTGCGGGCGCTTTTTTATTGCTGCTTAGCGTGGACGCTCGTTCAGAGTCGGCCCTGGGCCTGCAGCCA TTCCCGCACTAAAAACAGCG
Product: peptidoglycan synthetase
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 854; Mature: 854
Protein sequence:
>854_residues MKFVKYLLILAVCCVLLGAGSIFGLYKYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLQQIPPELVK AFIATEDSRFYEHHGVDPVGIFRAASVAMFSGHASQGASTITQQLARNFFLSPEKTLMRKIKEAFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKPIDQLTLSEMAVIAGLPKAPSTFNPLYSMDRATARRNVVLSRMLSEGYITQAQY DEARSEPIDASYHAPKIAFSAPYLSEMVRQEMVNRYGEQAYEDGYRVYTTITRKNQQAAQQAVRNNVLDYDMRHGYRGPA SVLWKVGETPWETKKIVDSLKRQSGYGPLFPAVVTSANAQEAVALLANGDSVSLTMEGVRWARRFISDTQQGATPRKVND VVQAGQQIWVRKVGDSWWLSQLPDVNSALVSINPQNGAIIALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYSVMANGGFLVNPFFIIKIENDQGGVLFEERPKIACPQCDLPVIYGDTPKSNVLENKDVEDVAT SAEPQNGNVPPQPQPQLEQANQSLVAQSGAQEYAPHVINTPLAFLIKSALNSNIFGEPGWMGTGWRAGRDLQRHDIGGKT GTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDSFMKSVLEGVPEEPLTPPP GIVTVNIDRSTGQLANGGNSRAEYFIEGTQPTQQAVREVGTTLTDGGGETHELF
Sequences:
>Translated_854_residues MKFVKYLLILAVCCVLLGAGSIFGLYKYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLQQIPPELVK AFIATEDSRFYEHHGVDPVGIFRAASVAMFSGHASQGASTITQQLARNFFLSPEKTLMRKIKEAFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKPIDQLTLSEMAVIAGLPKAPSTFNPLYSMDRATARRNVVLSRMLSEGYITQAQY DEARSEPIDASYHAPKIAFSAPYLSEMVRQEMVNRYGEQAYEDGYRVYTTITRKNQQAAQQAVRNNVLDYDMRHGYRGPA SVLWKVGETPWETKKIVDSLKRQSGYGPLFPAVVTSANAQEAVALLANGDSVSLTMEGVRWARRFISDTQQGATPRKVND VVQAGQQIWVRKVGDSWWLSQLPDVNSALVSINPQNGAIIALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYSVMANGGFLVNPFFIIKIENDQGGVLFEERPKIACPQCDLPVIYGDTPKSNVLENKDVEDVAT SAEPQNGNVPPQPQPQLEQANQSLVAQSGAQEYAPHVINTPLAFLIKSALNSNIFGEPGWMGTGWRAGRDLQRHDIGGKT GTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDSFMKSVLEGVPEEPLTPPP GIVTVNIDRSTGQLANGGNSRAEYFIEGTQPTQQAVREVGTTLTDGGGETHELF >Mature_854_residues MKFVKYLLILAVCCVLLGAGSIFGLYKYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQYGEKRRIPVTLQQIPPELVK AFIATEDSRFYEHHGVDPVGIFRAASVAMFSGHASQGASTITQQLARNFFLSPEKTLMRKIKEAFLAIRIEQLLNKDEIL ELYLNKIYLGYRAYGVGAAAQVYFGKPIDQLTLSEMAVIAGLPKAPSTFNPLYSMDRATARRNVVLSRMLSEGYITQAQY DEARSEPIDASYHAPKIAFSAPYLSEMVRQEMVNRYGEQAYEDGYRVYTTITRKNQQAAQQAVRNNVLDYDMRHGYRGPA SVLWKVGETPWETKKIVDSLKRQSGYGPLFPAVVTSANAQEAVALLANGDSVSLTMEGVRWARRFISDTQQGATPRKVND VVQAGQQIWVRKVGDSWWLSQLPDVNSALVSINPQNGAIIALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTES LALGSASFTPLQVARGYSVMANGGFLVNPFFIIKIENDQGGVLFEERPKIACPQCDLPVIYGDTPKSNVLENKDVEDVAT SAEPQNGNVPPQPQPQLEQANQSLVAQSGAQEYAPHVINTPLAFLIKSALNSNIFGEPGWMGTGWRAGRDLQRHDIGGKT GTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAWDSFMKSVLEGVPEEPLTPPP GIVTVNIDRSTGQLANGGNSRAEYFIEGTQPTQQAVREVGTTLTDGGGETHELF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=854, Percent_Identity=87.1194379391101, Blast_Score=1556, Evalue=0.0, Organism=Escherichia coli, GI1786343, Length=251, Percent_Identity=35.0597609561753, Blast_Score=144, Evalue=2e-35, Organism=Escherichia coli, GI1788867, Length=224, Percent_Identity=38.8392857142857, Blast_Score=137, Evalue=3e-33, Organism=Escherichia coli, GI1789601, Length=176, Percent_Identity=37.5, Blast_Score=99, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 93677; Mature: 93677
Theoretical pI: Translated: 7.63; Mature: 7.63
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKFVKYLLILAVCCVLLGAGSIFGLYKYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ CHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH YGEKRRIPVTLQQIPPELVKAFIATEDSRFYEHHGVDPVGIFRAASVAMFSGHASQGAST CCCCCCCCEEHHHCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHH ITQQLARNFFLSPEKTLMRKIKEAFLAIRIEQLLNKDEILELYLNKIYLGYRAYGVGAAA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCE QVYFGKPIDQLTLSEMAVIAGLPKAPSTFNPLYSMDRATARRNVVLSRMLSEGYITQAQY EEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH DEARSEPIDASYHAPKIAFSAPYLSEMVRQEMVNRYGEQAYEDGYRVYTTITRKNQQAAQ HHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH QAVRNNVLDYDMRHGYRGPASVLWKVGETPWETKKIVDSLKRQSGYGPLFPAVVTSANAQ HHHHHCCCCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHH EAVALLANGDSVSLTMEGVRWARRFISDTQQGATPRKVNDVVQAGQQIWVRKVGDSWWLS HEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH QLPDVNSALVSINPQNGAIIALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL HCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH AAEYLQRFGFPAQNIVHTESLALGSASFTPLQVARGYSVMANGGFLVNPFFIIKIENDQG HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCCEEEECCCEEECCEEEEEEECCCC GVLFEERPKIACPQCDLPVIYGDTPKSNVLENKDVEDVATSAEPQNGNVPPQPQPQLEQA CEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHH NQSLVAQSGAQEYAPHVINTPLAFLIKSALNSNIFGEPGWMGTGWRAGRDLQRHDIGGKT HHHHHHHCCHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC GTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAW CCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCHHHCCHHHHHHCCCCCCCCCCCHHH DSFMKSVLEGVPEEPLTPPPGIVTVNIDRSTGQLANGGNSRAEYFIEGTQPTQQAVREVG HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHC TTLTDGGGETHELF CEEECCCCCCCCCC >Mature Secondary Structure MKFVKYLLILAVCCVLLGAGSIFGLYKYIEPQLPDVATLKDVRLQIPMQVYSADGELIAQ CHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHEECCCEEECCCCHHHHH YGEKRRIPVTLQQIPPELVKAFIATEDSRFYEHHGVDPVGIFRAASVAMFSGHASQGAST CCCCCCCCEEHHHCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHH ITQQLARNFFLSPEKTLMRKIKEAFLAIRIEQLLNKDEILELYLNKIYLGYRAYGVGAAA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCE QVYFGKPIDQLTLSEMAVIAGLPKAPSTFNPLYSMDRATARRNVVLSRMLSEGYITQAQY EEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH DEARSEPIDASYHAPKIAFSAPYLSEMVRQEMVNRYGEQAYEDGYRVYTTITRKNQQAAQ HHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH QAVRNNVLDYDMRHGYRGPASVLWKVGETPWETKKIVDSLKRQSGYGPLFPAVVTSANAQ HHHHHCCCCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHH EAVALLANGDSVSLTMEGVRWARRFISDTQQGATPRKVNDVVQAGQQIWVRKVGDSWWLS HEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH QLPDVNSALVSINPQNGAIIALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGL HCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCC TLASMLNDVPISRWDAGAGSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEHHHHHHHHCHHH AAEYLQRFGFPAQNIVHTESLALGSASFTPLQVARGYSVMANGGFLVNPFFIIKIENDQG HHHHHHHCCCCHHHHEEHHHHCCCCCCCCHHHHHCCCEEEECCCEEECCEEEEEEECCCC GVLFEERPKIACPQCDLPVIYGDTPKSNVLENKDVEDVATSAEPQNGNVPPQPQPQLEQA CEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHH NQSLVAQSGAQEYAPHVINTPLAFLIKSALNSNIFGEPGWMGTGWRAGRDLQRHDIGGKT HHHHHHHCCHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC GTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRDLGRTTASGAIKDQISGYEGGAKSAQPAW CCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCHHHCCHHHHHHCCCCCCCCCCCHHH DSFMKSVLEGVPEEPLTPPPGIVTVNIDRSTGQLANGGNSRAEYFIEGTQPTQQAVREVG HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHC TTLTDGGGETHELF CEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3882429; 9278503; 3920658; 7006606; 9841666 [H]