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The map label for this gene is exuR [H]

Identifier: 238896619

GI number: 238896619

Start: 4603268

End: 4604044

Strand: Direct

Name: exuR [H]

Synonym: KP1_4820

Alternate gene names: 238896619

Gene position: 4603268-4604044 (Clockwise)

Preceding gene: 238896618

Following gene: 238896620

Centisome position: 87.71

GC content: 53.15

Gene sequence:

>777_bases
ATGGAAATCATTGAACCACGCCGTCTATATCAGCAGCTTGCCGCTGAGCTGAAGACGCGCATCGAACAAGGTGTCTACCT
TGTAGGGGATAAGCTGCCCGCCGAGCGCTTCATCGCCGATGAAAAAAACGTCAGCCGCACCGTGGTTCGTGAAGCCATTA
TCATGCTGGAAGTGGAAGGGTATGTCGAAGTCCGCAAAGGGTCGGGTATCCACGTTATCTCCAACCATCCGAAATACCAG
CAGGTGGCCGATGAAAGCCTTGAGTTCGCCAACTATGGCCCCTTTGAACTGCTGCAGGCGCGGCAGCTAATTGAAAGCAA
TATTGCCGAATTCGCGGCGACTCAGGTGACCAAACAGGACATCATGAAGCTGATGGAGATTCAGGAGAAAGCGCGTAACG
AGAAATGTTTCCGCGACTCCGAGTGGGACCTGCAGTTTCACGTCCAGGTGGCGCTGGCGACGCAGAACAGCGCGCTGGCG
GCGATCGTGGAAAAGATGTGGACCCAGCGCGTGCATAACCCCTACTGGAAAAAGCTGCATGAGCATATCGACCTGCGTAC
GGTCGATAACTGGTGCGACGACCACGATCAGATCCTGAAAGCTCTGCTGCGAAAAGATCCCAACGCCGCCAAGCTGGCGA
TGTGGCAGCATCTGGAAAATACCAAGCAAATGTTGTTCAACGAAACCAGCGATGACTTTGAATTTAATGCCGATCGCTAC
TTATTTGCCGAAAACCCAGTCGTTCATCTCGATACCGCAGTCAACGGCGCGAAATAA

Upstream 100 bases:

>100_bases
AGCCGCCTTCTCAGGCGGCTTTTTCATGCCTGCCAGTGGTGGAAAGCGCGTAAAAGTGGTATAACAAATCGAATATTGTC
GCCATCTTCCGGGAGCGAAT

Downstream 100 bases:

>100_bases
GGCCTTATCCCTCCGGCGCGCCCCCCTGCGCGCCTGTCTGACAGTGAGGCTGGAGTAAGCAAGTCATATATAGTGTCAGC
CTGTGTAAATCCTCTCGCCT

Product: DNA-binding transcriptional repressor ExuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MEIIEPRRLYQQLAAELKTRIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVISNHPKYQ
QVADESLEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQEKARNEKCFRDSEWDLQFHVQVALATQNSALA
AIVEKMWTQRVHNPYWKKLHEHIDLRTVDNWCDDHDQILKALLRKDPNAAKLAMWQHLENTKQMLFNETSDDFEFNADRY
LFAENPVVHLDTAVNGAK

Sequences:

>Translated_258_residues
MEIIEPRRLYQQLAAELKTRIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVISNHPKYQ
QVADESLEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQEKARNEKCFRDSEWDLQFHVQVALATQNSALA
AIVEKMWTQRVHNPYWKKLHEHIDLRTVDNWCDDHDQILKALLRKDPNAAKLAMWQHLENTKQMLFNETSDDFEFNADRY
LFAENPVVHLDTAVNGAK
>Mature_258_residues
MEIIEPRRLYQQLAAELKTRIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVISNHPKYQ
QVADESLEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQEKARNEKCFRDSEWDLQFHVQVALATQNSALA
AIVEKMWTQRVHNPYWKKLHEHIDLRTVDNWCDDHDQILKALLRKDPNAAKLAMWQHLENTKQMLFNETSDDFEFNADRY
LFAENPVVHLDTAVNGAK

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=258, Percent_Identity=90.6976744186046, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1790780, Length=252, Percent_Identity=46.031746031746, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1790032, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789353, Length=237, Percent_Identity=24.4725738396624, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786303, Length=224, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29993; Mature: 29993

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIEPRRLYQQLAAELKTRIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVISNHPKYQQVADESLEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMEIQEKARNEKCFRDSEWDLQFHVQVALATQNSALAAIVEKMWTQRVHNPYWKKLH
HHHHHHHHHHHHCHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHH
EHIDLRTVDNWCDDHDQILKALLRKDPNAAKLAMWQHLENTKQMLFNETSDDFEFNADRY
HHCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEE
LFAENPVVHLDTAVNGAK
EEECCCEEEEECCCCCCC
>Mature Secondary Structure
MEIIEPRRLYQQLAAELKTRIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVISNHPKYQQVADESLEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMEIQEKARNEKCFRDSEWDLQFHVQVALATQNSALAAIVEKMWTQRVHNPYWKKLH
HHHHHHHHHHHHCHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHH
EHIDLRTVDNWCDDHDQILKALLRKDPNAAKLAMWQHLENTKQMLFNETSDDFEFNADRY
HHCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEE
LFAENPVVHLDTAVNGAK
EEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]