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The map label for this gene is exuT [H]

Identifier: 238896618

GI number: 238896618

Start: 4601839

End: 4603140

Strand: Direct

Name: exuT [H]

Synonym: KP1_4819

Alternate gene names: 238896618

Gene position: 4601839-4603140 (Clockwise)

Preceding gene: 238896614

Following gene: 238896619

Centisome position: 87.68

GC content: 59.45

Gene sequence:

>1302_bases
ATGCGTAAAATTAAAGGGTTACGTTGGTACATGATCGCGCTGGTGACGCTGGGCACCGTGCTGGGCTACCTGACCCGTAA
CACCGTAGCGGCGGCCGCGCCGACGCTGATGGAAGAGTTACACATTTCGACCCAACAGTACTCCTATATCATTGCAGCCT
ATTCCGCTGCCTATACCGTTATGCAGCCCGTCGCGGGGTATGTCCTTGATATTCTGGGGACCAAAATTGGCTATGCCTTC
TTCGCCATCGCCTGGGCGGTATTCTGCGGCTCAACGGCTCTGGCCGGCAGCTGGGGTGGACTGGCGCTGGCCCGTGGCGC
AGTCGGCGCAGCGGAGGCCGCAATGATCCCCGCCGGCCTGAAGGCCAGCTCAGAGTGGTTCCCGGCAAAAGAGCGTTCTA
TCGCGGTGGGCTACTTCAACGTGGGTTCCTCTATAGGCGCCATGATCGCGCCACCGTTGGTGGTGTGGGCGATTGTCATG
CACAGCTGGCAGATGGCGTTCATCATCTCCGGGGTATTGAGCTTCGCCTGGGCTATCGCCTGGCTTATCTTCTACAAACA
TCCGCGCGACCAGAAAAAATTATCTGACGAAGAACGTGACTACATCATTGGCGGTCAGGAGTCTCAGCATCAGACCAATA
ACGCGAAGAAAATGTCGCCGTGGCAAATCCTGCGCAACCGTCAGTTCTGGGGTATCGCCCTGCCGCGCTTCCTCGCTGAG
CCGGCCTGGGGGACCTTTAACGCCTGGATCCCGCTGTTCATGTTCAAAGTTTACGGTTTTAACCTGAAAGAGATCGCCAT
GTTCGCCTGGATGCCGATGCTGTTCGCCGACCTCGGCTGCATCGTCGGCGGATATCTGCCGCCGCTGTTCCAGCGCTGGT
TTGGCGTCAACCTGATCGTGTCGCGTAAAATGGTGGTCACCATGGGCGCCCTGCTAATGATTGGCCCGGGGATGATCGGC
CTGTTCACCAGCCCGTACGTGGCGATTGCCCTGCTGTGCATCGGCGGGTTCGCTCACCAGGCGCTGTCCGGGGCGCTGAT
TACCCTCTCTTCCGACGTCTTTGGCCGTAACGAAGTCGCTACCGCTAACGGTCTGACCGGGATGGCCGCCTGGCTGGCGA
GCACCATGTTCGCCCTGGTCGTCGGCGCGCTGGCGGATACCATCGGCTTTAGCCCGCTGTTTGCGGTACTGGCCGTCTTT
GACCTCCTTGGCGCGCTGGTTATCTGGACGGTGCTGAAAAACAAACCGGCTGACGATGACTCGACGCCGCTTAGCAGCCG
CAAACCGGTCACGCAGAGTTAG

Upstream 100 bases:

>100_bases
GGACTACCCTCCTGAATCCTCCGTTTCGCTTTCCCGGCCGCTTATTGCGCTCGGTAAAGGCCGCACCTGATGCGGAAAGA
TAACAGACGATGAGGTTTAC

Downstream 100 bases:

>100_bases
ATCGAATGGCAAGGTAATCGCCGATCAAGCCGCCTTCTCAGGCGGCTTTTTCATGCCTGCCAGTGGTGGAAAGCGCGTAA
AAGTGGTATAACAAATCGAA

Product: transport protein of hexuronates

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAF
FAIAWAVFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM
HSWQMAFIISGVLSFAWAIAWLIFYKHPRDQKKLSDEERDYIIGGQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE
PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIG
LFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVF
DLLGALVIWTVLKNKPADDDSTPLSSRKPVTQS

Sequences:

>Translated_433_residues
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAF
FAIAWAVFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM
HSWQMAFIISGVLSFAWAIAWLIFYKHPRDQKKLSDEERDYIIGGQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE
PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIG
LFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVF
DLLGALVIWTVLKNKPADDDSTPLSSRKPVTQS
>Mature_433_residues
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAF
FAIAWAVFCGSTALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM
HSWQMAFIISGVLSFAWAIAWLIFYKHPRDQKKLSDEERDYIIGGQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE
PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIG
LFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVATANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVF
DLLGALVIWTVLKNKPADDDSTPLSSRKPVTQS

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=384, Percent_Identity=23.6979166666667, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148743791, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI9966811, Length=261, Percent_Identity=26.0536398467433, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI154800443, Length=401, Percent_Identity=23.6907730673317, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI2367193, Length=419, Percent_Identity=93.0787589498807, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI2367379, Length=433, Percent_Identity=26.0969976905312, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082320, Length=410, Percent_Identity=26.3414634146341, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1789515, Length=332, Percent_Identity=26.5060240963855, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1789152, Length=350, Percent_Identity=24.2857142857143, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082071, Length=429, Percent_Identity=23.3100233100233, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533554, Length=378, Percent_Identity=24.3386243386243, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533556, Length=378, Percent_Identity=24.3386243386243, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24580790, Length=292, Percent_Identity=25.6849315068493, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550460, Length=412, Percent_Identity=24.7572815533981, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641682, Length=260, Percent_Identity=26.1538461538462, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24655255, Length=370, Percent_Identity=25.4054054054054, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129235, Length=279, Percent_Identity=27.9569892473118, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573708, Length=426, Percent_Identity=23.4741784037559, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573707, Length=426, Percent_Identity=23.4741784037559, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639764, Length=370, Percent_Identity=21.6216216216216, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648416, Length=260, Percent_Identity=25, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356189, Length=260, Percent_Identity=25, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24658696, Length=276, Percent_Identity=24.2753623188406, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47001; Mature: 47001

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MQPVAGYVLDILGTKIGYAFFAIAWAVFCGSTALAGSWGGLALARGAVGAAEAAMIPAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCCCHHHHHHCCCCC
KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIA
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLIFYKHPRDQKKLSDEERDYIIGGQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE
HHHHHCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHCC
PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIV
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC
TANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
STPLSSRKPVTQS
CCCCCCCCCCCCC
>Mature Secondary Structure
MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MQPVAGYVLDILGTKIGYAFFAIAWAVFCGSTALAGSWGGLALARGAVGAAEAAMIPAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHCCCCHHHHHHCCCCC
KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAIA
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLIFYKHPRDQKKLSDEERDYIIGGQESQHQTNNAKKMSPWQILRNRQFWGIALPRFLAE
HHHHHCCCCHHHHCCCCCCCEEECCCCCHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHCC
PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIV
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQALSGALITLSSDVFGRNEVA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC
TANGLTGMAAWLASTMFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLKNKPADDD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
STPLSSRKPVTQS
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]