Click here to switch to the map view.

The map label for this gene is arsC [H]

Identifier: 238896415

GI number: 238896415

Start: 4396830

End: 4397252

Strand: Reverse

Name: arsC [H]

Synonym: KP1_4590

Alternate gene names: 238896415

Gene position: 4397252-4396830 (Counterclockwise)

Preceding gene: 238896416

Following gene: 238896414

Centisome position: 83.78

GC content: 60.99

Gene sequence:

>423_bases
ATGAGCATCACCATTTACCATAACCCTGACTGCGGCACCTCGCGTAATACGCTGGCGCTGATCCGTAACAGCGGCGCCGA
GCCCACCGTTATCTATTATCTGGAGACGCCGCCGTCGGGTGATGAGCTGCGCCAGCTGCTCGCCGCGATGGGGATCCCGG
TGCGCGCGCTGCTGCGGAAAAACGTCGAACCCTACGACGCGCTGGGCCTGGCGGAAGACCGGTTTACTGACGACCAGATA
ATCGACTTTATGCTTCAGCATCCGATCCTGATTAACCGTCCGATCGTAACGACGCCGCAGGGCACCCGACTCTGCCGCCC
GTCAGAGGTGGTGCTGGAGATCCTGACGGCGCCGCAACAAGGCGCATTCGTGAAGGAGGACGGTGAGCCAGTCATTGATG
CCGCAGGGCAGCGTGTGAAATAG

Upstream 100 bases:

>100_bases
TTATTTCCGCTGCGGCATCACCATGACCCTGCCGGTGCTGCTTGTGACGCTGGCCGCGCTGGCGCTGCGTCTCTCCTTCA
ACCAGCCATGAGAACGTACT

Downstream 100 bases:

>100_bases
CGCGCAGAATGGCGCCGGCTGTAGCAGCCGGCATGCCGTGTTAAACCTGCTGTATGGTAGGCTCTCCAGGTATGTAGCGC
CTGGATTGCTGACAATATTC

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MSITIYHNPDCGTSRNTLALIRNSGAEPTVIYYLETPPSGDELRQLLAAMGIPVRALLRKNVEPYDALGLAEDRFTDDQI
IDFMLQHPILINRPIVTTPQGTRLCRPSEVVLEILTAPQQGAFVKEDGEPVIDAAGQRVK

Sequences:

>Translated_140_residues
MSITIYHNPDCGTSRNTLALIRNSGAEPTVIYYLETPPSGDELRQLLAAMGIPVRALLRKNVEPYDALGLAEDRFTDDQI
IDFMLQHPILINRPIVTTPQGTRLCRPSEVVLEILTAPQQGAFVKEDGEPVIDAAGQRVK
>Mature_139_residues
SITIYHNPDCGTSRNTLALIRNSGAEPTVIYYLETPPSGDELRQLLAAMGIPVRALLRKNVEPYDALGLAEDRFTDDQII
DFMLQHPILINRPIVTTPQGTRLCRPSEVVLEILTAPQQGAFVKEDGEPVIDAAGQRVK

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=139, Percent_Identity=77.6978417266187, Blast_Score=228, Evalue=1e-61,
Organism=Escherichia coli, GI1788841, Length=114, Percent_Identity=42.1052631578947, Blast_Score=96, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15453; Mature: 15322

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIYHNPDCGTSRNTLALIRNSGAEPTVIYYLETPPSGDELRQLLAAMGIPVRALLRK
CEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHC
NVEPYDALGLAEDRFTDDQIIDFMLQHPILINRPIVTTPQGTRLCRPSEVVLEILTAPQQ
CCCCCHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEECCCCCCCCCHHHHHHHHHCCCCC
GAFVKEDGEPVIDAAGQRVK
CCEECCCCCCHHHCCCCCCC
>Mature Secondary Structure 
SITIYHNPDCGTSRNTLALIRNSGAEPTVIYYLETPPSGDELRQLLAAMGIPVRALLRK
EEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHC
NVEPYDALGLAEDRFTDDQIIDFMLQHPILINRPIVTTPQGTRLCRPSEVVLEILTAPQQ
CCCCCHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEECCCCCCCCCHHHHHHHHHCCCCC
GAFVKEDGEPVIDAAGQRVK
CCEECCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]