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The map label for this gene is arsB [H]

Identifier: 238896416

GI number: 238896416

Start: 4397262

End: 4398554

Strand: Reverse

Name: arsB [H]

Synonym: KP1_4591

Alternate gene names: 238896416

Gene position: 4398554-4397262 (Counterclockwise)

Preceding gene: 238896417

Following gene: 238896415

Centisome position: 83.81

GC content: 60.94

Gene sequence:

>1293_bases
ATGTTGCTGGCAGGTACGATTTTTATCCTGACCCTGGTGCTGGTGATTTGGCAGCCGCGGGGGTTAGGGATCGGCTGGAG
CGCGGCCTTTGGCGCGGCGCTGGCGCTGGCCACCGGTGGCGTACAGGTAGCCGATATCCCGGTGGTATGGCATATCGTCT
GGAATGCGACCGCCACCTTTATCGCCGTTATCATTATCAGCCTGCTGCTTGATGAGTCTGGCTTTTTCGAATGGGCCGCG
CTGCACGTTTCCCGCTGGGGAAGAGGCCGGGGTCGTCTGCTGTTTACCTGGATTATCCTGCTCGGCGCGGCTGTGGCGGC
GCTGTTTGCCAACGATGGGGCGGCGCTGATCCTCACGCCAATCGTGATTGCCATGCTGCGAGCGCTGGGGTTCAGCAAGG
GAACGATGCTGGCCTTTGTCATGGCCGCCGGATTTATTGCCGATACCGCCAGCCTGCCGCTGGTGGTGTCGAATCTGGTG
AATATCGTTTCGGCAGATTTCTTTGCCATCGGCTTCAGGGAGTACGCTTCGGTGATGGTGCCGGTCGATCTCGCGGCGAT
CCTCACCACCCTGGCGATGCTGCACCTGTTCTTTCGCAAGGATATCCCGCCGGCCTGGGATATGGCGTTACTAAAAGCGC
CGGCCACGGCGATAAAAGATCCAGCGACGTTCCGCACCGGCTGGGGCGTGCTGCTGCTGTTGCTGGCTGGCTTTTTCGTC
CTTGAACCGCTGGGGATCCCGGTCAGCGCCATCGCGGCGCTCGGCGCCGGGATCCTGTTTGCTGTCGCGAAGCGCGGGCG
GGTAATTAACACCGGCAAGGTGCTGCGCGGCGCCCCGTGGCAGATAGTGATCTTCTCGCTGGGAATGTATCTGGTGGTGT
ATGGTCTGCGAAACGCCGGGTTAACGGACTATCTGACCACGGTGCTGAACATGCTGGCGGAGCGCGGGCTCTGGGCCGCG
ACGCTGGGCACCGGTATCCTGTCGGCCTTCCTCTCTTCAATAATGAATAATATGCCCAGCGTACTGGTCGGCGCCCTGTC
GATTGATGGCAGCGCGGCAACAGGGACGATCAAAGAGGCCATGATTTATGCCAACGTCATCGGCTGCGATCTGGGGCCCA
AGATCACGCCAATTGGTAGCCTGGCCACGCTGCTCTGGCTGCATGTGCTGGCGCAGAAGTACATCACCATCGGTTGGGGG
TATTATTTCCGCTGCGGCATCACCATGACCCTGCCGGTGCTGCTTGTGACGCTGGCCGCGCTGGCGCTGCGTCTCTCCTT
CAACCAGCCATGA

Upstream 100 bases:

>100_bases
TGTGCGGCTGATGATCAGCAGACTGGCTGGCGGGCCGGGTTGCCGGTAAAAAATTTATCTTAACATATATGATTTTTCGA
ATGTGATTGGCGGAGGAACG

Downstream 100 bases:

>100_bases
GAACGTACTATGAGCATCACCATTTACCATAACCCTGACTGCGGCACCTCGCGTAATACGCTGGCGCTGATCCGTAACAG
CGGCGCCGAGCCCACCGTTA

Product: Ars family arsenical pump

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: Arsenic efflux pump protein [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLLAGTIFILTLVLVIWQPRGLGIGWSAAFGAALALATGGVQVADIPVVWHIVWNATATFIAVIIISLLLDESGFFEWAA
LHVSRWGRGRGRLLFTWIILLGAAVAALFANDGAALILTPIVIAMLRALGFSKGTMLAFVMAAGFIADTASLPLVVSNLV
NIVSADFFAIGFREYASVMVPVDLAAILTTLAMLHLFFRKDIPPAWDMALLKAPATAIKDPATFRTGWGVLLLLLAGFFV
LEPLGIPVSAIAALGAGILFAVAKRGRVINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTDYLTTVLNMLAERGLWAA
TLGTGILSAFLSSIMNNMPSVLVGALSIDGSAATGTIKEAMIYANVIGCDLGPKITPIGSLATLLWLHVLAQKYITIGWG
YYFRCGITMTLPVLLVTLAALALRLSFNQP

Sequences:

>Translated_430_residues
MLLAGTIFILTLVLVIWQPRGLGIGWSAAFGAALALATGGVQVADIPVVWHIVWNATATFIAVIIISLLLDESGFFEWAA
LHVSRWGRGRGRLLFTWIILLGAAVAALFANDGAALILTPIVIAMLRALGFSKGTMLAFVMAAGFIADTASLPLVVSNLV
NIVSADFFAIGFREYASVMVPVDLAAILTTLAMLHLFFRKDIPPAWDMALLKAPATAIKDPATFRTGWGVLLLLLAGFFV
LEPLGIPVSAIAALGAGILFAVAKRGRVINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTDYLTTVLNMLAERGLWAA
TLGTGILSAFLSSIMNNMPSVLVGALSIDGSAATGTIKEAMIYANVIGCDLGPKITPIGSLATLLWLHVLAQKYITIGWG
YYFRCGITMTLPVLLVTLAALALRLSFNQP
>Mature_430_residues
MLLAGTIFILTLVLVIWQPRGLGIGWSAAFGAALALATGGVQVADIPVVWHIVWNATATFIAVIIISLLLDESGFFEWAA
LHVSRWGRGRGRLLFTWIILLGAAVAALFANDGAALILTPIVIAMLRALGFSKGTMLAFVMAAGFIADTASLPLVVSNLV
NIVSADFFAIGFREYASVMVPVDLAAILTTLAMLHLFFRKDIPPAWDMALLKAPATAIKDPATFRTGWGVLLLLLAGFFV
LEPLGIPVSAIAALGAGILFAVAKRGRVINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTDYLTTVLNMLAERGLWAA
TLGTGILSAFLSSIMNNMPSVLVGALSIDGSAATGTIKEAMIYANVIGCDLGPKITPIGSLATLLWLHVLAQKYITIGWG
YYFRCGITMTLPVLLVTLAALALRLSFNQP

Specific function: Involved in arsenical resistance. Thought to form the channel of an arsenite pump [H]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsB family [H]

Homologues:

Organism=Escherichia coli, GI87082277, Length=428, Percent_Identity=85.981308411215, Blast_Score=696, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802 [H]

Pfam domain/function: PF02040 ArsB [H]

EC number: NA

Molecular weight: Translated: 45641; Mature: 45641

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAGTIFILTLVLVIWQPRGLGIGWSAAFGAALALATGGVQVADIPVVWHIVWNATATF
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHH
IAVIIISLLLDESGFFEWAALHVSRWGRGRGRLLFTWIILLGAAVAALFANDGAALILTP
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IVIAMLRALGFSKGTMLAFVMAAGFIADTASLPLVVSNLVNIVSADFFAIGFREYASVMV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVDLAAILTTLAMLHLFFRKDIPPAWDMALLKAPATAIKDPATFRTGWGVLLLLLAGFFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHH
LEPLGIPVSAIAALGAGILFAVAKRGRVINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAG
HCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHCCCC
LTDYLTTVLNMLAERGLWAATLGTGILSAFLSSIMNNMPSVLVGALSIDGSAATGTIKEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCHHHHHH
MIYANVIGCDLGPKITPIGSLATLLWLHVLAQKYITIGWGYYFRCGITMTLPVLLVTLAA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHCCCHHHHHHHHHHHHHH
LALRLSFNQP
HHHHHCCCCC
>Mature Secondary Structure
MLLAGTIFILTLVLVIWQPRGLGIGWSAAFGAALALATGGVQVADIPVVWHIVWNATATF
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEHHHHHHHHHH
IAVIIISLLLDESGFFEWAALHVSRWGRGRGRLLFTWIILLGAAVAALFANDGAALILTP
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IVIAMLRALGFSKGTMLAFVMAAGFIADTASLPLVVSNLVNIVSADFFAIGFREYASVMV
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVDLAAILTTLAMLHLFFRKDIPPAWDMALLKAPATAIKDPATFRTGWGVLLLLLAGFFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHH
LEPLGIPVSAIAALGAGILFAVAKRGRVINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAG
HCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHCCCC
LTDYLTTVLNMLAERGLWAATLGTGILSAFLSSIMNNMPSVLVGALSIDGSAATGTIKEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCHHHHHH
MIYANVIGCDLGPKITPIGSLATLLWLHVLAQKYITIGWGYYFRCGITMTLPVLLVTLAA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHCCCHHHHHHHHHHHHHH
LALRLSFNQP
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9006011 [H]