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The map label for this gene is sdaC [H]

Identifier: 238896258

GI number: 238896258

Start: 4236763

End: 4238052

Strand: Direct

Name: sdaC [H]

Synonym: KP1_4414

Alternate gene names: 238896258

Gene position: 4236763-4238052 (Clockwise)

Preceding gene: 238896257

Following gene: 238896259

Centisome position: 80.72

GC content: 56.67

Gene sequence:

>1290_bases
ATGGAAACCACTCAAACCAGCACCATCGTTTCGGGCGAAACCCGCAGCGGATGGCGTAAAACCGACACCATGTGGATGCT
GGGCCTGTACGGCACGGCGATTGGCGCGGGCGTCTTGTTCCTGCCGATCAACGCCGGCGTTGGCGGCATGATCCCCCTGA
TCATCATGGCGATTCTGGCCTTCCCGATGACTTTCTTCGCCCACCGCGGCATGACCCGCTTCGTGCTCTCCGGGAAAAAC
CCGGGCGAAGACATCACCGAAGTAGTGGAAGAACACTTCGGCGTAGGCGCAGGTAAGCTGATTACCCTGCTTTATTTCTT
CGCTATCTACCCGATCCTGCTGGTTTATAGCGTGGCGATCACTAACACCGTCGAAACCTTCATGGCGCACCAGCTGCACA
TGACGCCGCCGCCGCGCGCCATTCTGTCGCTGATCCTGATTGTCGGCATGATGACCATTGTGCGTTTCGGCGAGCAGATG
ATTGTGAAAGCGATGAGCGTGCTGGTGTTCCCGTTCGTTATCGCGCTGATGGTGCTGGCTCTGTATCTGATCCCGCAGTG
GAACGGCGCGGCGCTGGAGACGCTCTCCCTGAGCGGCGCTTCCGTTACCGGCAACGGCCTGCTGATGACCCTGTGGCTGG
CGATCCCGGTGATGGTCTTCTCCTTCAACCACTCGCCGATCATCTCTTCCTTCGCGGTAGCCAAACGTGAAGAGTACGGC
GAAGGCGCTGAGAAGAAATGCTCCAGTATCCTCGCGCGCGCCCACATCATGATGGTGCTGACCGTGATGTTCTTCGTCTT
CAGCTGCGTTCTGAGCCTCTCTCCGGCAGACCTGGCGGCGGCGAAAGAGCAGAACATCTCGATTCTGTCTTACCTGGCGA
ACCACTTTAACGCGCCAATCATTGCCTGGATGGCACCGATCATCGCGATGATCGCCATCACCAAATCCTTCCTTGGCCAC
TATCTGGGCGCTCGCGAAGGCTTTAACGGCATGGTGATTAAATCCCTGCGCAGTAAAGGCAAATCGATTGAAATCAACAA
ACTGAACAAGCTGACCGCGCTGTTCATGCTGATCACCACCTGGATTGTGGCAACCCTGAACCCGAGCATCCTCGGTATGA
TCGAGACCCTTGGCGGCCCGATTATCGCGATGATCCTGTTCCTGATGCCGATGTACGCGATTCAGAAAGTCCCGGCGATG
CGTAAATACAGCGGCCATATCAGCAACGTCTTCGTGGTGATTATGGGCCTGATTGCCATCTCCGCGATCTTCTACTCTCT
GTTCAGCTAA

Upstream 100 bases:

>100_bases
ATTACGGAGAAAATTTCTAAAAAAACCGTAATTAAACGAATTTCATGTTACGCAATTGTATTTATTCATTAGATTTTGTT
GATTCCTCCAGGAGATACAG

Downstream 100 bases:

>100_bases
TTCATTCAACGCCTCCCCCCGCGCCGCTTTACGGCGGCGCGCTTTCCGACAGCACGGGAATACATATGATCAGCGTATTC
GATATCTTTAAAATCGGCAT

Product: putative HAAAP-family serine transport protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
METTQTSTIVSGETRSGWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGMTRFVLSGKN
PGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVETFMAHQLHMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSVLVFPFVIALMVLALYLIPQWNGAALETLSLSGASVTGNGLLMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSSILARAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRSKGKSIEINKLNKLTALFMLITTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS

Sequences:

>Translated_429_residues
METTQTSTIVSGETRSGWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGMTRFVLSGKN
PGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVETFMAHQLHMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSVLVFPFVIALMVLALYLIPQWNGAALETLSLSGASVTGNGLLMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSSILARAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRSKGKSIEINKLNKLTALFMLITTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS
>Mature_429_residues
METTQTSTIVSGETRSGWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGMTRFVLSGKN
PGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAITNTVETFMAHQLHMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSVLVFPFVIALMVLALYLIPQWNGAALETLSLSGASVTGNGLLMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
EGAEKKCSSILARAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPIIAWMAPIIAMIAITKSFLGH
YLGAREGFNGMVIKSLRSKGKSIEINKLNKLTALFMLITTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVIMGLIAISAIFYSLFS

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=92.7738927738928, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=50.4524886877828, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1789211, Length=416, Percent_Identity=39.4230769230769, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI145693183, Length=422, Percent_Identity=27.2511848341232, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1789961, Length=410, Percent_Identity=26.3414634146341, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46799; Mature: 46799

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTQTSTIVSGETRSGWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGMTRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVETFMAHQLHMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSVLVFPFVIALMVLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLSGASVTGNGLLMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHHCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EGAEKKCSSILARAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAMIAITKSFLGHYLGAREGFNGMVIKSLRSKGKSIEINKLNKLTALFMLITT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVIMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC
>Mature Secondary Structure
METTQTSTIVSGETRSGWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGMTRFVLSGKNPGEDITEVVEEHFGVGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVETFMAHQLHMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSVLVFPFVIALMVLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLSGASVTGNGLLMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHHCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
EGAEKKCSSILARAHIMMVLTVMFFVFSCVLSLSPADLAAAKEQNISILSYLANHFNAPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCH
IAWMAPIIAMIAITKSFLGHYLGAREGFNGMVIKSLRSKGKSIEINKLNKLTALFMLITT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVIMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]