| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is relA [H]
Identifier: 238896245
GI number: 238896245
Start: 4218690
End: 4220927
Strand: Reverse
Name: relA [H]
Synonym: KP1_4398
Alternate gene names: 238896245
Gene position: 4220927-4218690 (Counterclockwise)
Preceding gene: 238896246
Following gene: 238896244
Centisome position: 80.42
GC content: 59.52
Gene sequence:
>2238_bases ATGGTTGCGGTAAGAAGTGCACATCTTAATAAAGCTGGTGAATTTGACCCGAAGAAATGGATCGCGAGTCTGGGAATTTC CAGCCAGCAGTCGTGTGAGCGCTTAGCCGAAACCTGGGATTATTGTCGCGAAAAAACGCAAGGACACCCGCAGGCGGACC TGCTGCTGTGGCGGGGCGTCGAAATGGTGGAGATCCTCTCCACCCTAAGTATGGACATCGATACGCTGCGCGCGGCGCTG CTGTTCCCGCTGGCCGACGGCGAAGTTGTCAGCGAAGAGGTGATGCAGGAGAGCGTAGGTAAATCGGTCGTGACCCTGAT TCACGGGGTGCGGGACATGGCCGCTATCCGCCAGCTGAAGGCTACCCATACCGACTCGGTCTCTTCCGAGCAGGTGGATA ACATTCGCCGTATGCTGCTGGCGATGGTTGACGATTTCCGCTGCGTGGTCATCAAACTTGCTGAGCGTATCGCGCATCTG CGCGAGGTCAAGGACGCGCCGGAAGATGAGCGCGTTCTTGCGGCGAAAGAGTGCACCAATATCTATGCTCCCCTGGCGAA CCGCTTAGGTATCGGCCAGCTGAAGTGGGAGCTGGAAGATTACTGCTTCCGCTATCTGCACCCGGCGGAATACAAGCGCA TTGCCAAACTGCTCCACGAGCGCCGTATCGACCGCGAGCATTACATCGAAGAGTTTGTCGGCCACCTGCGCTCAGAGATG AAAGCCGAAGGCGTCAAGGCGGAAGTCTATGGCCGGCCGAAGCATATCTACAGTATCTGGCGCAAAATGCAGAAAAAACA CCTCGCTTTCGACGAGCTGTTTGACGTTCGCGCGGTGCGTATTGTGGCTGAGCGTTTGCAGGATTGCTATGCCGCGCTGG GGATCGTCCATACTCACTACCGCCATCTGCCGGATGAATTCGACGACTACGTGGCCAACCCGAAACCCAACGGTTACCAG TCTATCCATACCGTGGTGCTGGGGCCGAGCGGCAAGACGGTGGAGATTCAGATCCGCACCCGGCAGATGCATGAAGACGC CGAGCTGGGCGTGGCCGCGCACTGGAAGTACAAAGAGGGCGCGGGAGCCGGCACCAGCGGCGGCCGCGGCTATGAAGACC GTATCGCCTGGCTGCGTAAGCTGATTGCCTGGCAGGAAGAGATGGCCGACTCCGGCGAGATGCTCGACGAAGTGCGCAGC CAGGTCTTCGACGACCGGGTGTATGTCTTTACGCCGAAAGGCGACGTGGTGGACCTGCCTGCGGGGTCGACGCCGCTGGA CTTTGCCTATCATATTCACAGCGATGTCGGCCATCGCTGCATCGGCGCCAAAATTGGCGGCCGCATCGTGCCGTTCACCT ACCAGCTGCAGATGGGCGATCAGATCGAAATTATTACCCAGAAGCAGCCGAACCCGAGCCGTGACTGGCTGAACCCTAAC CTCGGCTATGTGACCACCAGCCGCGGACGTTCGAAGATCCACGCCTGGTTCCGTAAGCAGGATCGCGACAAGAACATTCT CGCCGGTCGGCAGATCCTCGACGACGAGCTGGAGCATTTGGGCATCAGCCTGAAGGATGCGGAAAAGCACCTGCTGCCGC GCTATAACTTCAACGAGCTCGATGAACTGCTGGCCGCCATCGGCGGTGGCGATATCCGTCTCAACCAGATGGTCAACTTC CTGCAGGCGCAGTTCAATAAACCTAGCGCCGCCGAGCAGGATGCGGCCGCGCTGAAGCAACTGCAGCAGAAAACCTACAC GCCGCAAAATCGCACCAAGGACAATGGCCGGGTAGTGGTGGAAGGGGTAGGCAACCTGATGCACCATATTGCCCGCTGCT GCCAGCCAATCCCGGGCGACGAGATCGTCGGCTTTATCACCCAGGGGCGCGGGATCTCCGTGCATCGCGCGGACTGCGAT CAGCTGGCAGAACTGCAGTCGCATGCCCCGGAGCGCATCGTCGATGCGGTATGGGGCGAAAGCTACTCGGCGGGCTACTC GCTGGTGGTCAGGGTGGAGGCGAACGATCGCAGCGGTTTACTGCGCGATATCACTACCATCCTCGCCAATGAGAAGGTGA ACGTGCTGGGCGTCGCCAGCCGCAGCGATACCCGTCAGCAGCTGGCAACCATCGATATGACCATCGAGATTTACAACCTG CAGGTGCTGGGCCGGGTGCTCGGTAAGCTCAACCAGGTGCCGGATGTGATCGACGCGCGCCGTCTGCACGGCGGTTAA
Upstream 100 bases:
>100_bases AGAGCCACCCTGGCCATGAATGCTGACGCGACCTGCAGGATGACATGTAGAAAGTTGAGGCTTGCCGACTTCGGCAGGCC GGTCCCTTAAGGAGAGGACA
Downstream 100 bases:
>100_bases TTCGTCTGTAGGCCGGATAAGGCGAAGCCGCCATCCGGCAATTTCGCAACGTCGGATAAGGTCTAAACGCCTTATCCGGC CGACTATTTTTTAAATTTCC
Product: GDP/GTP pyrophosphokinase
Products: NA
Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]
Number of amino acids: Translated: 745; Mature: 745
Protein sequence:
>745_residues MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGVEMVEILSTLSMDIDTLRAAL LFPLADGEVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLKATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHL REVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIEEFVGHLRSEM KAEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQ SIHTVVLGPSGKTVEIQIRTRQMHEDAELGVAAHWKYKEGAGAGTSGGRGYEDRIAWLRKLIAWQEEMADSGEMLDEVRS QVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPN LGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNELDELLAAIGGGDIRLNQMVNF LQAQFNKPSAAEQDAAALKQLQQKTYTPQNRTKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCD QLAELQSHAPERIVDAVWGESYSAGYSLVVRVEANDRSGLLRDITTILANEKVNVLGVASRSDTRQQLATIDMTIEIYNL QVLGRVLGKLNQVPDVIDARRLHGG
Sequences:
>Translated_745_residues MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGVEMVEILSTLSMDIDTLRAAL LFPLADGEVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLKATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHL REVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIEEFVGHLRSEM KAEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQ SIHTVVLGPSGKTVEIQIRTRQMHEDAELGVAAHWKYKEGAGAGTSGGRGYEDRIAWLRKLIAWQEEMADSGEMLDEVRS QVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPN LGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNELDELLAAIGGGDIRLNQMVNF LQAQFNKPSAAEQDAAALKQLQQKTYTPQNRTKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCD QLAELQSHAPERIVDAVWGESYSAGYSLVVRVEANDRSGLLRDITTILANEKVNVLGVASRSDTRQQLATIDMTIEIYNL QVLGRVLGKLNQVPDVIDARRLHGG >Mature_745_residues MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGVEMVEILSTLSMDIDTLRAAL LFPLADGEVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLKATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHL REVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIEEFVGHLRSEM KAEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQ SIHTVVLGPSGKTVEIQIRTRQMHEDAELGVAAHWKYKEGAGAGTSGGRGYEDRIAWLRKLIAWQEEMADSGEMLDEVRS QVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPN LGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNELDELLAAIGGGDIRLNQMVNF LQAQFNKPSAAEQDAAALKQLQQKTYTPQNRTKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCD QLAELQSHAPERIVDAVWGESYSAGYSLVVRVEANDRSGLLRDITTILANEKVNVLGVASRSDTRQQLATIDMTIEIYNL QVLGRVLGKLNQVPDVIDARRLHGG
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ACT domain [H]
Homologues:
Organism=Escherichia coli, GI1789147, Length=745, Percent_Identity=94.2281879194631, Blast_Score=1449, Evalue=0.0, Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=31.8435754189944, Blast_Score=394, Evalue=1e-110,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5 [H]
Molecular weight: Translated: 84170; Mature: 84170
Theoretical pI: Translated: 6.69; Mature: 6.69
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGV CCEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCH EMVEILSTLSMDIDTLRAALLFPLADGEVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLK HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTN HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH IYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIEEFVGHLRSEM HHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH KAEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHY HHCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RHLPDEFDDYVANPKPNGYQSIHTVVLGPSGKTVEIQIRTRQMHEDAELGVAAHWKYKEG HHCCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEHHHCCHHCCCEEEEEEECCC AGAGTSGGRGYEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLP CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCEEECC AGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPN CCCCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC LGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNEL CCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHH DELLAAIGGGDIRLNQMVNFLQAQFNKPSAAEQDAAALKQLQQKTYTPQNRTKDNGRVVV HHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEE EGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCDQLAELQSHAPERIVDAVWGE HHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCC SYSAGYSLVVRVEANDRSGLLRDITTILANEKVNVLGVASRSDTRQQLATIDMTIEIYNL CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHEEEEEEHHH QVLGRVLGKLNQVPDVIDARRLHGG HHHHHHHHHHHCCCHHHHHHHHCCC >Mature Secondary Structure MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGV CCEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCH EMVEILSTLSMDIDTLRAALLFPLADGEVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLK HHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTN HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH IYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIEEFVGHLRSEM HHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH KAEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHY HHCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RHLPDEFDDYVANPKPNGYQSIHTVVLGPSGKTVEIQIRTRQMHEDAELGVAAHWKYKEG HHCCHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEHHHCCHHCCCEEEEEEECCC AGAGTSGGRGYEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLP CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCEEECC AGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPN CCCCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC LGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNEL CCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHH DELLAAIGGGDIRLNQMVNFLQAQFNKPSAAEQDAAALKQLQQKTYTPQNRTKDNGRVVV HHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEE EGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCDQLAELQSHAPERIVDAVWGE HHHHHHHHHHHHHCCCCCCCHHEEEEECCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCC SYSAGYSLVVRVEANDRSGLLRDITTILANEKVNVLGVASRSDTRQQLATIDMTIEIYNL CCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHEEEEEEHHH QVLGRVLGKLNQVPDVIDARRLHGG HHHHHHHHHHHCCCHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]