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The map label for this gene is uraA [H]

Identifier: 238895947

GI number: 238895947

Start: 3894666

End: 3895952

Strand: Reverse

Name: uraA [H]

Synonym: KP1_4072

Alternate gene names: 238895947

Gene position: 3895952-3894666 (Counterclockwise)

Preceding gene: 238895948

Following gene: 238895946

Centisome position: 74.23

GC content: 58.66

Gene sequence:

>1287_bases
ATGACGCGCCGTGCCATCGGGGTGAGTGAAAGACCGCCGCTTTTACAGACAATCCCGCTTAGTTTGCAACATCTGTTCGC
CATGTTTGGCGCAACGGTACTGGTGCCTATTCTGTTCCACATTAACCCGGCCACCGTCCTGCTGTTCAACGGCATCGGTA
CGCTGTTGTACCTCTTTATCTGTAAAGGCAAAATTCCCGCTTATCTGGGATCAAGCTTCGCTTTTATCTCCCCGGTGCTG
CTGCTGTTGCCGCTGGGCTACGAAGTGGCGCTGGGCGGCTTTATTATGTGCGGCGTGCTGTTCTGCCTCGTCTCCTTTAT
TGTCAAAAAAGCCGGTACCGGCTGGCTGGATGTGATGTTCCCGCCGGCGGCGATGGGCGCCATCGTGGCGGTTATCGGCC
TCGAACTGGCGGGCGTGGCGGCTAATATGGCCGGGCTGCTGCCGGCCGACGGCCAGTCACCGGACAGTAAAACCATTATT
ATCTCGATGGTGACCCTGGCGGTGACGGTGTTCGGATCCGTGCTGTTCCGCGGCTTCCTGGCGATTATTCCGATCCTGAT
CGGCGTGCTGGTGGGCTATGCGCTGTCGTTTGTGATGGGCGTGGTCGATACCACCCCGATCGCCGAGGCCCACTGGTTCG
CGCTGCCGACTTTCTACACTCCGCGCTTTGAGTGGTTTGCTATCTTCACCATACTGCCCGCCGCGCTGGTGGTGATTGCC
GAGCACGTGGGGCATCTGGTGGTGACCGCTAATATCGTTAAGCGCGATCTGATCCGCGACCCGGGCCTGCATCGTTCGAT
GTTTGCCAACGGCCTGTCGACGATCGTTTCCGGCTTCTTCGGTTCGACGCCCAACACTACCTACGGTGAAAATATCGGCG
TGATGGCGATTACCCGGGTCTACAGCACCTGGGTAATCGGCGGCGCGGCGATCATTGCGATTCTGCTCTCCTGCGTCGGC
AAACTGGCGGCGGCTATCCAGATCATCCCGGTGCCGGTGATGGGCGGCGTTTCCCTGCTGCTGTACGGGGTGATTGGCGC
CTCGGGGATCCGCGTACTGATTGAATCGAAGGTGGATTACAGTAAAGCGCAGAATCTGATCCTCACCTCCGTGATCCTGA
TCATCGGCGTTAGCGGCGCTAAAGTGCACATTGGCGCCGCCGAGCTGAAAGGGATGGCGCTGGCGACTATCGTGGGCATC
GCCCTCAGCCTGATTTTCAAGCTTATCAGCGTCCTGCGTCCGGAAGAGGTGGTCCTCGACGCGGCGGATAGCGAAGAGTT
TAAATAA

Upstream 100 bases:

>100_bases
AATAAAATATACCGCGAAAAAAGCCGACTTTGAGAGTCGGCTTTTTTTTGAATAAAAGTAATCCACAGCAAATAACAGAC
GACTCTCAGAGGAATACACT

Downstream 100 bases:

>100_bases
CGATCGCCTGACCGGGCGGCGATCCCGCCCGGTTCTCTCCTGACCTAAATCTGTGGTAAACTCTTCGCGTTTTTCTGTAA
GCCTATGTTGAGGTCCATCT

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPILFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAANMAGLLPADGQSPDSKTII
ISMVTLAVTVFGSVLFRGFLAIIPILIGVLVGYALSFVMGVVDTTPIAEAHWFALPTFYTPRFEWFAIFTILPAALVVIA
EHVGHLVVTANIVKRDLIRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIIAILLSCVG
KLAAAIQIIPVPVMGGVSLLLYGVIGASGIRVLIESKVDYSKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
ALSLIFKLISVLRPEEVVLDAADSEEFK

Sequences:

>Translated_428_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPILFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAANMAGLLPADGQSPDSKTII
ISMVTLAVTVFGSVLFRGFLAIIPILIGVLVGYALSFVMGVVDTTPIAEAHWFALPTFYTPRFEWFAIFTILPAALVVIA
EHVGHLVVTANIVKRDLIRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIIAILLSCVG
KLAAAIQIIPVPVMGGVSLLLYGVIGASGIRVLIESKVDYSKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
ALSLIFKLISVLRPEEVVLDAADSEEFK
>Mature_427_residues
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPILFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLL
LLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAANMAGLLPADGQSPDSKTIII
SMVTLAVTVFGSVLFRGFLAIIPILIGVLVGYALSFVMGVVDTTPIAEAHWFALPTFYTPRFEWFAIFTILPAALVVIAE
HVGHLVVTANIVKRDLIRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIIAILLSCVGK
LAAAIQIIPVPVMGGVSLLLYGVIGASGIRVLIESKVDYSKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIA
LSLIFKLISVLRPEEVVLDAADSEEFK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=238, Percent_Identity=27.3109243697479, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI40316845, Length=238, Percent_Identity=27.3109243697479, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788843, Length=425, Percent_Identity=93.6470588235294, Blast_Score=788, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=425, Percent_Identity=38.1176470588235, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI87082181, Length=450, Percent_Identity=26, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790087, Length=441, Percent_Identity=25.6235827664399, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541904, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=216, Percent_Identity=25.462962962963, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=135, Percent_Identity=31.8518518518519, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356175, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45118; Mature: 44987

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCC
>Mature Secondary Structure 
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPILFHINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPAAMGAIVAVIGLELAGVAANMAGLLPADGQSPDSKTIIISMVTLAVTVFGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYALSFVMGVVDTTPIAEAHWFALPTFYTPRFEWFAIFTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKRDLIRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAIIAILLSCVGKLAAAIQIIPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCH
SKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIALSLIFKLISVLRPEEVVLD
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEE
AADSEEFK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]