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The map label for this gene is hda [H]

Identifier: 238895946

GI number: 238895946

Start: 3893866

End: 3894543

Strand: Reverse

Name: hda [H]

Synonym: KP1_4071

Alternate gene names: 238895946

Gene position: 3894543-3893866 (Counterclockwise)

Preceding gene: 238895947

Following gene: 238895941

Centisome position: 74.2

GC content: 59.44

Gene sequence:

>678_bases
TTGCCACTGTATCTTCCTGACGACGAAACCTTCGCGAGTTTCTGGCCGGGTGATAATCCTTCCCTACTTGCCGCCCTCCA
GAACGTACTGCGCCAGGAACACAGCGGGTACATTTATATCTGGTCACGTGAAGGGGCAGGTCGTAGCCACCTGTTACACG
CCGCCTGCGCGGAGCTTTCCCAGCGCGGGGATGCGGTAGGCTACGTGCCGCTGGATAAACGGACGTGGTTTGTGCCCGAG
GTGCTGGAGGGGATGGAACAGCTGGCGCTGGTGTGCATCGATAACATCGAGTGCGTCGCCGGCGATGAGCCCTGGGAGAT
GGCCATCTTTAATCTCTATAACCGGATCCTGGAATCAGGCAAAACCCGGCTGCTGATCACCGGCGATCGGCCGCCGCGGC
AGCTGAATCTTGGCCTGCCGGATCTGGCCTCACGGCTGGACTGGGGGCAGATCTATAAGCTGCAGCCGCTGTCGGATGAA
GACAAACTGCAGGCGCTGCAGCTGCGCGCCAGACTGCGCGGCTTCGAGATGCCGGAAGATGTGTGCCGCTTCCTGCTGAA
GCGGCTGGATCGCGAGATGCGTTCGCTGTTTATGACCCTCGATCAGCTGGATCATGCCTCGATTACCGCTCAGCGCAAGC
TGACGATCCCCTTCGTGAAAGAGATCCTTAAGCTTTAG

Upstream 100 bases:

>100_bases
TCCCGCCCGGTTCTCTCCTGACCTAAATCTGTGGTAAACTCTTCGCGTTTTTCTGTAAGCCTATGTTGAGGTCCATCTGA
ACGCACCGGCACAGCTCTCT

Downstream 100 bases:

>100_bases
TCCGCCAGGGGAGTCAGCTCCTGCTCCGTCAGCCCGGTCAACCGGGCGACCAGGTCGCGCGGAAGGCCGCTGTGCAGCAT
AGCGACAGCGATGCGCTGCG

Product: DNA replication initiation factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MPLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPE
VLEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDE
DKLQALQLRARLRGFEMPEDVCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL

Sequences:

>Translated_225_residues
MPLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPE
VLEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDE
DKLQALQLRARLRGFEMPEDVCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL
>Mature_224_residues
PLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEV
LEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDED
KLQALQLRARLRGFEMPEDVCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=225, Percent_Identity=93.7777777777778, Blast_Score=435, Evalue=1e-124,
Organism=Escherichia coli, GI2367267, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 25823; Mature: 25692

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELS
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
QRGDAVGYVPLDKRTWFVPEVLEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESG
HCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCC
KTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFEMPED
CCEEEEECCCCCCEECCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHH
VCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEECHHHHHHHCC
>Mature Secondary Structure 
PLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELS
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
QRGDAVGYVPLDKRTWFVPEVLEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESG
HCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCC
KTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFEMPED
CCEEEEECCCCCCEECCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHH
VCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA