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The map label for this gene is upp [H]

Identifier: 238895948

GI number: 238895948

Start: 3896048

End: 3896701

Strand: Reverse

Name: upp [H]

Synonym: KP1_4073

Alternate gene names: 238895948

Gene position: 3896701-3896048 (Counterclockwise)

Preceding gene: 238895949

Following gene: 238895947

Centisome position: 74.24

GC content: 56.42

Gene sequence:

>654_bases
GTGGCTGCCCCTCAGAGGAGAAAGAGAATGAAGATTGTGGAAGTCAAACACCCACTCGTCAAACACAAGCTAGGCCTGAT
GCGCGAGCACGACATCAGCACCAAACGCTTCCGTGAACTCGCCTCAGAAGTGGGCAGCTTACTGACTTATGAAGCCACCG
CCGATCTGGAGACTGAGAAAGTCACTATTGAAGGCTGGAACGGTCCGGTGGAAGTCGAGCAGATCAAGGGCAAGAAAATT
ACCGTTGTGCCTATCCTGCGCGCTGGCCTCGGCATGATGGAAGGGGTGCTGGAGCACGTGCCAAGCGCGCGTATCAGCGT
GGTCGGTATCTATCGCAATGAAGAAACCCTCGAGCCGGTGCCTTACTTCCAGAAACTGGTGTCTAACATCGATGAACGTA
TGGCGCTGGTCGTTGACCCGATGCTGGCCACCGGTGGGTCGATGATCGCCACTATCGATCTGCTGAAAAACGCCGGCTGC
ACCAGCATCAAGGTGCTGGTGCTGGTGGCGGCGCCGGAAGGGATTGCCGCGCTGGAGAAAGCCCACCCGGACGTTGAGCT
GTACACCGCCTCTGTCGATAAGGGACTGAACGAGCACGGGTATATCATTCCCGGTCTCGGCGATGCCGGCGACAAGATTT
TTGGAACGAAATAA

Upstream 100 bases:

>100_bases
CTCCGGTTTTTTTGTCTCTAAATCACTTTGCTTGATATACGTCAAGCAAGATGGGTATGGCACAATCCGCAAAAAGCGGT
ATAATCCCGCGATTTTTTTT

Downstream 100 bases:

>100_bases
AATATACCGCGAAAAAAGCCGACTTTGAGAGTCGGCTTTTTTTTGAATAAAAGTAATCCACAGCAAATAACAGACGACTC
TCAGAGGAATACACTATGAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAAPQRRKRMKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEVEQIKGKKI
TVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGC
TSIKVLVLVAAPEGIAALEKAHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_217_residues
MAAPQRRKRMKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEVEQIKGKKI
TVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGC
TSIKVLVLVAAPEGIAALEKAHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK
>Mature_216_residues
AAPQRRKRMKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEVEQIKGKKIT
VVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGCT
SIKVLVLVAAPEGIAALEKAHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.2178217821782, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.2178217821782, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=94.2307692307692, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.865671641791, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=224, Percent_Identity=33.4821428571429, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=28.0788177339901, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23661; Mature: 23530

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPQRRKRMKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLETEK
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCE
VTIEGWNGPVEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPV
EEEECCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
PYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGCTSIKVLVLVAAPEGIAALEK
HHHHHHHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHCCCCCEEEEEEEEECCCCHHHHHH
AHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK
CCCCEEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AAPQRRKRMKIVEVKHPLVKHKLGLMREHDISTKRFRELASEVGSLLTYEATADLETEK
CCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCE
VTIEGWNGPVEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPV
EEEECCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCC
PYFQKLVSNIDERMALVVDPMLATGGSMIATIDLLKNAGCTSIKVLVLVAAPEGIAALEK
HHHHHHHHHHHHHHHHHCCHHHHCCCCCEEHHHHHHCCCCCEEEEEEEEECCCCHHHHHH
AHPDVELYTASVDKGLNEHGYIIPGLGDAGDKIFGTK
CCCCEEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA