| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is menD [H]
Identifier: 238895789
GI number: 238895789
Start: 3733854
End: 3735542
Strand: Reverse
Name: menD [H]
Synonym: KP1_3903
Alternate gene names: 238895789
Gene position: 3735542-3733854 (Counterclockwise)
Preceding gene: 238895790
Following gene: 238895788
Centisome position: 71.17
GC content: 65.54
Gene sequence:
>1689_bases TTGATACCGGACAATTTCATGTCAGTAAGCGCATTTAACCGACGCTGGGCGGCGGTGATCCTGGAAGCTTTAACGCGCCA TGGCGTGCAGCATATCTGCATCGCGCCGGGCTCGCGCTCGACACCCTTAACCCTGGCGGCGGCGGAAAACCGCGCCTTTA TCCATCATACCCATTTCGACGAGCGCGGCCTCGGCCACCTGGCGCTCGGCCTGGCGAAGGCCAGCCGGCAGCCGGTGGCG GTGATAGTCACCTCCGGGACCGCCACCGCAAACCTCTATCCGGCGCTGATTGAGGCAGGGCTCACCGGTGAAAAGCTGAT CCTGTTAACCGCCGACCGTCCGCCGGAGCTGATCGACTGCGGCGCGAACCAGGCTATCCGCCAGCCGGGGATGTTTGCCT CCCATCCTGCGCAGACGATTTCTTTGCCGCGTCCCTCGCAGGATATTCCTGCCCGTTGGCTGGTCTCAACCATCGACCAG GCGCTGGGGGCGCTGCACGCCGGCGGGGTGCATATTAACTGTCCGTTCGCTGAACCGCTGTATGGTGATATGGATGAGAC CGGCGTGGAGTGGCAGCAGCAGCTCGGCAACTGGTGGCAGAGCGACAAACCCTGGCTGCGCCAGGCGCTGCAGTTAGAGA GCGAGAAGCAGCGCGACTGGTTCTTCTGGCGACAAAAACGCGGCGTCGTCGTGGCGGGCAGAATGAGCGCCGCGGAAGGG AAAAAGGTCGCTGAGTGGGCGCAGACCCTCGGCTGGCCGCTGATCGGCGATGTCCTGTCGCAGACCGGGCAGCCGCTGCC GTGCGCCGACCTGTGGCTGGGCAACGGCAAAGCGGTCAGCGAGCTGGCGCAGGCGCAGATCGTCGTGCAACTCGGCAGCA GCCTGACCGGCAAACGCGTGCTCCAGTGGCAGGCGACCTGCGAGCCGGATGAATACTGGCTGGTGGATAATCTGCCCGGT CGCCTCGACCCGGCGCAGCACCGCGGTCGCCGTCTGCTCTCAAGCGTTGAGCGCTGGCTCGAATTACATCCGGCGGAGAA ACGCCAGCCGTGGGCGACGGTGATCCCACAGCTTGCCGGGCAGGCGTGGCAGGCTGCGGTCGCCAGCAACGAGCCTTTTG GCGAAGCGCAGCTGGCGCAGCGTATTCGGCGCTATCTGCCGGAGCAGGGCCAATTGTTTGTTGGCAACAGCCTGGTGGTG CGCCTGATCGACGCCCTGGCGCAGCTACCGGCCGGGTATCCGGTCTACAGCAACCGCGGCGCCAGCGGCATCGATGGCCT GATCGCCACTGCGGCCGGCGTGCAGCGCGCCAGCGCCCGACCGACGCTGGCCATCGTTGGCGATCTCTCCGCGCTATACG ATCTCAACTCGCTGGCCCTGCTGCGCCAGGCGTCGGCGCCGCTGGTGCTGATCGTGGTGAATAACAACGGCGGGCAGATT TTTTCTATGCTGCCGACGCCGCAGGACGAACGCCGTCAGTTCTATTTAATGCCGCAGGACGTGGATTTCAGCCACGCGGC GGCGATGTTCGGCCTGGCCTATCATCGCCCTGATGACTGGCCGTCGCTGGATGAGGCGCTGGCCGGCGCCTGGCGCAGGG CAGGGGCGACGGTGATTGAGCTGGCGGTCAATGAGACCGACGGCGCGCAGACCCTCCAGCAGCTGCTGGCGCAGGTAAGT CGCCTGTGA
Upstream 100 bases:
>100_bases AAAGCGGCCGGGCTGCGCTCGCTGCTGTGTCCATAAAGCTTGAATGACGATGCATATCAAAACGACGTCACTTTGCCTTA TCTATACTTAGCATCAATAT
Downstream 100 bases:
>100_bases TCCTCAGCGCTGCTGTCGACAACGGCCAGCCGGGCTATCCCTGGCTGGTGTTTCTGCACGGTTTTTCCGGCGACCGCAAC GAGTGGCGGAAAGTGGGCGA
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 562; Mature: 562
Protein sequence:
>562_residues MIPDNFMSVSAFNRRWAAVILEALTRHGVQHICIAPGSRSTPLTLAAAENRAFIHHTHFDERGLGHLALGLAKASRQPVA VIVTSGTATANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPAQTISLPRPSQDIPARWLVSTIDQ ALGALHAGGVHINCPFAEPLYGDMDETGVEWQQQLGNWWQSDKPWLRQALQLESEKQRDWFFWRQKRGVVVAGRMSAAEG KKVAEWAQTLGWPLIGDVLSQTGQPLPCADLWLGNGKAVSELAQAQIVVQLGSSLTGKRVLQWQATCEPDEYWLVDNLPG RLDPAQHRGRRLLSSVERWLELHPAEKRQPWATVIPQLAGQAWQAAVASNEPFGEAQLAQRIRRYLPEQGQLFVGNSLVV RLIDALAQLPAGYPVYSNRGASGIDGLIATAAGVQRASARPTLAIVGDLSALYDLNSLALLRQASAPLVLIVVNNNGGQI FSMLPTPQDERRQFYLMPQDVDFSHAAAMFGLAYHRPDDWPSLDEALAGAWRRAGATVIELAVNETDGAQTLQQLLAQVS RL
Sequences:
>Translated_562_residues MIPDNFMSVSAFNRRWAAVILEALTRHGVQHICIAPGSRSTPLTLAAAENRAFIHHTHFDERGLGHLALGLAKASRQPVA VIVTSGTATANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPAQTISLPRPSQDIPARWLVSTIDQ ALGALHAGGVHINCPFAEPLYGDMDETGVEWQQQLGNWWQSDKPWLRQALQLESEKQRDWFFWRQKRGVVVAGRMSAAEG KKVAEWAQTLGWPLIGDVLSQTGQPLPCADLWLGNGKAVSELAQAQIVVQLGSSLTGKRVLQWQATCEPDEYWLVDNLPG RLDPAQHRGRRLLSSVERWLELHPAEKRQPWATVIPQLAGQAWQAAVASNEPFGEAQLAQRIRRYLPEQGQLFVGNSLVV RLIDALAQLPAGYPVYSNRGASGIDGLIATAAGVQRASARPTLAIVGDLSALYDLNSLALLRQASAPLVLIVVNNNGGQI FSMLPTPQDERRQFYLMPQDVDFSHAAAMFGLAYHRPDDWPSLDEALAGAWRRAGATVIELAVNETDGAQTLQQLLAQVS RL >Mature_562_residues MIPDNFMSVSAFNRRWAAVILEALTRHGVQHICIAPGSRSTPLTLAAAENRAFIHHTHFDERGLGHLALGLAKASRQPVA VIVTSGTATANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPAQTISLPRPSQDIPARWLVSTIDQ ALGALHAGGVHINCPFAEPLYGDMDETGVEWQQQLGNWWQSDKPWLRQALQLESEKQRDWFFWRQKRGVVVAGRMSAAEG KKVAEWAQTLGWPLIGDVLSQTGQPLPCADLWLGNGKAVSELAQAQIVVQLGSSLTGKRVLQWQATCEPDEYWLVDNLPG RLDPAQHRGRRLLSSVERWLELHPAEKRQPWATVIPQLAGQAWQAAVASNEPFGEAQLAQRIRRYLPEQGQLFVGNSLVV RLIDALAQLPAGYPVYSNRGASGIDGLIATAAGVQRASARPTLAIVGDLSALYDLNSLALLRQASAPLVLIVVNNNGGQI FSMLPTPQDERRQFYLMPQDVDFSHAAAMFGLAYHRPDDWPSLDEALAGAWRRAGATVIELAVNETDGAQTLQQLLAQVS RL
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=556, Percent_Identity=84.3525179856115, Blast_Score=967, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 61408; Mature: 61408
Theoretical pI: Translated: 6.71; Mature: 6.71
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIPDNFMSVSAFNRRWAAVILEALTRHGVQHICIAPGSRSTPLTLAAAENRAFIHHTHFD CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCEEEEECCCC ERGLGHLALGLAKASRQPVAVIVTSGTATANLYPALIEAGLTGEKLILLTADRPPELIDC CCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHEEC GANQAIRQPGMFASHPAQTISLPRPSQDIPARWLVSTIDQALGALHAGGVHINCPFAEPL CCCHHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC YGDMDETGVEWQQQLGNWWQSDKPWLRQALQLESEKQRDWFFWRQKRGVVVAGRMSAAEG CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCC KKVAEWAQTLGWPLIGDVLSQTGQPLPCADLWLGNGKAVSELAQAQIVVQLGSSLTGKRV HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHHHHHHCCCCCCCEE LQWQATCEPDEYWLVDNLPGRLDPAQHRGRRLLSSVERWLELHPAEKRQPWATVIPQLAG EEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC QAWQAAVASNEPFGEAQLAQRIRRYLPEQGQLFVGNSLVVRLIDALAQLPAGYPVYSNRG HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCC ASGIDGLIATAAGVQRASARPTLAIVGDLSALYDLNSLALLRQASAPLVLIVVNNNGGQI CCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEE FSMLPTPQDERRQFYLMPQDVDFSHAAAMFGLAYHRPDDWPSLDEALAGAWRRAGATVIE EEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE LAVNETDGAQTLQQLLAQVSRL EEECCCCHHHHHHHHHHHHHCC >Mature Secondary Structure MIPDNFMSVSAFNRRWAAVILEALTRHGVQHICIAPGSRSTPLTLAAAENRAFIHHTHFD CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCEEEEECCCC ERGLGHLALGLAKASRQPVAVIVTSGTATANLYPALIEAGLTGEKLILLTADRPPELIDC CCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHEEC GANQAIRQPGMFASHPAQTISLPRPSQDIPARWLVSTIDQALGALHAGGVHINCPFAEPL CCCHHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC YGDMDETGVEWQQQLGNWWQSDKPWLRQALQLESEKQRDWFFWRQKRGVVVAGRMSAAEG CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCCC KKVAEWAQTLGWPLIGDVLSQTGQPLPCADLWLGNGKAVSELAQAQIVVQLGSSLTGKRV HHHHHHHHHHCCHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHHHHHHCCCCCCCEE LQWQATCEPDEYWLVDNLPGRLDPAQHRGRRLLSSVERWLELHPAEKRQPWATVIPQLAG EEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC QAWQAAVASNEPFGEAQLAQRIRRYLPEQGQLFVGNSLVVRLIDALAQLPAGYPVYSNRG HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCC ASGIDGLIATAAGVQRASARPTLAIVGDLSALYDLNSLALLRQASAPLVLIVVNNNGGQI CCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEE FSMLPTPQDERRQFYLMPQDVDFSHAAAMFGLAYHRPDDWPSLDEALAGAWRRAGATVIE EEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE LAVNETDGAQTLQQLLAQVSRL EEECCCCHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA