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The map label for this gene is menF [H]

Identifier: 238895790

GI number: 238895790

Start: 3735607

End: 3736926

Strand: Reverse

Name: menF [H]

Synonym: KP1_3904

Alternate gene names: 238895790

Gene position: 3736926-3735607 (Counterclockwise)

Preceding gene: 238895791

Following gene: 238895789

Centisome position: 71.2

GC content: 63.71

Gene sequence:

>1320_bases
ATGTGGGGTTTTACTACCGTGGAGGTTTGCGTGCTGTCTGTTTCCACTGCGCTGGCCCGTTTGCAAGACGGCCTGGGCGA
GTCTTTTCCAGACTTGCCCGGCACGCGAATTATCGATGTTGCTTTTCCGCTGAATGATGCCTTCGATCCGCTACTATGGT
GCGGCCAGCAGGCGCAATGGCCGCAGTTTTACTGGCAGCAGCGCAATGGCGATGAGGAACTGGCGACGCTGGGGGCGGTA
AAAACCTTTACCTCGCTCGACGCGGCGAACCGCTTTTTACGCCAGGCCGGCCGGCAGGATCTGCGTATCTGCGGCCTGAA
TGCGTTTGAACCGCAGCAGGGCAGCCTGGCGCTGCCGCGTCTGGAGTGGCGCCGGTGCGGCGGCAGGGCCGTGCTGCGGC
TGGTGCTGCATAGTGATATCTCCCTGCGTGAGGATGCCGCGACGGCCCGCGCGTTTCTCGCCAGCCTGACAACCACTCAG
GCGACTCCCGGCGCCATACCGCCGTTGCTGAGCGAGCGCCACTCATCCGACTATCCTCAATGGCAGGCAATGATTGCGCG
GGCGACTAAGGCGATCAGCGCCGGTGAAATGGATAAAGTAGTGCTGGCGCGGGCAACCGACCTGCAGTTTGCCGCCCCGC
TGGACGCCGTGAGCATCATGGCGGCTAGCCGGCGCAGCAATCTTAACTGTTTTCATTTCCTGATGGCGTTCAATGCCCGG
CAGGCGTTTTTCGGCTCCACGCCAGAACGGCTGTGGCGCCGGCGCGGCGCGCTGCTGCGCACCGAAGCGCTGGCAGGGAC
CGTCGCGAACCATCAGGAAGACGCGAAGGCGCAGCAACTGGCCGACTGGTTGATGAAAGATGACAAAAACCAGCGGGAAA
ACATGCTGGTGGTAGAGGATATCTGCCAGCGCCTGCAGAGTGAGGCCTCGACGCTGGACGTCCTGCCGCCGCAGGTGGTG
AGGCTGCGTAAGGTGCAGCATCTCCGACGCTGCATCTGGACCGAGCTGGCGGCGCCTGACGACAGCCGCTGTCTGCTGCA
GCTGCAGCCCACCGCCGCGGTGGCCGGCCTGCCGCGCTGGGCGGCGCTGGCGTTCATTCAGCGCCATGAACCGTTTTCCC
GCGAATGGTACGCCGGGTCCGCCGGGTATCTGTCACTGGCGCAAAGCGAGTTTTGCGTGGCGCTGCGTTCGGCGAAAGTG
GACCACGACACCCTGCGGCTGTATGCCGGGGCGGGGATCGTTAGCGGCTCTGATGCACAGCAGGAGTGGCAGGAGATTGA
CAACAAAGCGGCCGGGCTGCGCTCGCTGCTGTGTCCATAA

Upstream 100 bases:

>100_bases
CTGCACCCTCGTCCACACGCAGCTCTGGCCCGGCGAGCGGGTAAGATAAAACCCGCTCCCTCATCATGGGTACTGCTATT
CCGCCGTCGAACCCCTTATA

Downstream 100 bases:

>100_bases
AGCTTGAATGACGATGCATATCAAAACGACGTCACTTTGCCTTATCTATACTTAGCATCAATATTTGATACCGGACAATT
TCATGTCAGTAAGCGCATTT

Product: menaquinone-specific isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MWGFTTVEVCVLSVSTALARLQDGLGESFPDLPGTRIIDVAFPLNDAFDPLLWCGQQAQWPQFYWQQRNGDEELATLGAV
KTFTSLDAANRFLRQAGRQDLRICGLNAFEPQQGSLALPRLEWRRCGGRAVLRLVLHSDISLREDAATARAFLASLTTTQ
ATPGAIPPLLSERHSSDYPQWQAMIARATKAISAGEMDKVVLARATDLQFAAPLDAVSIMAASRRSNLNCFHFLMAFNAR
QAFFGSTPERLWRRRGALLRTEALAGTVANHQEDAKAQQLADWLMKDDKNQRENMLVVEDICQRLQSEASTLDVLPPQVV
RLRKVQHLRRCIWTELAAPDDSRCLLQLQPTAAVAGLPRWAALAFIQRHEPFSREWYAGSAGYLSLAQSEFCVALRSAKV
DHDTLRLYAGAGIVSGSDAQQEWQEIDNKAAGLRSLLCP

Sequences:

>Translated_439_residues
MWGFTTVEVCVLSVSTALARLQDGLGESFPDLPGTRIIDVAFPLNDAFDPLLWCGQQAQWPQFYWQQRNGDEELATLGAV
KTFTSLDAANRFLRQAGRQDLRICGLNAFEPQQGSLALPRLEWRRCGGRAVLRLVLHSDISLREDAATARAFLASLTTTQ
ATPGAIPPLLSERHSSDYPQWQAMIARATKAISAGEMDKVVLARATDLQFAAPLDAVSIMAASRRSNLNCFHFLMAFNAR
QAFFGSTPERLWRRRGALLRTEALAGTVANHQEDAKAQQLADWLMKDDKNQRENMLVVEDICQRLQSEASTLDVLPPQVV
RLRKVQHLRRCIWTELAAPDDSRCLLQLQPTAAVAGLPRWAALAFIQRHEPFSREWYAGSAGYLSLAQSEFCVALRSAKV
DHDTLRLYAGAGIVSGSDAQQEWQEIDNKAAGLRSLLCP
>Mature_439_residues
MWGFTTVEVCVLSVSTALARLQDGLGESFPDLPGTRIIDVAFPLNDAFDPLLWCGQQAQWPQFYWQQRNGDEELATLGAV
KTFTSLDAANRFLRQAGRQDLRICGLNAFEPQQGSLALPRLEWRRCGGRAVLRLVLHSDISLREDAATARAFLASLTTTQ
ATPGAIPPLLSERHSSDYPQWQAMIARATKAISAGEMDKVVLARATDLQFAAPLDAVSIMAASRRSNLNCFHFLMAFNAR
QAFFGSTPERLWRRRGALLRTEALAGTVANHQEDAKAQQLADWLMKDDKNQRENMLVVEDICQRLQSEASTLDVLPPQVV
RLRKVQHLRRCIWTELAAPDDSRCLLQLQPTAAVAGLPRWAALAFIQRHEPFSREWYAGSAGYLSLAQSEFCVALRSAKV
DHDTLRLYAGAGIVSGSDAQQEWQEIDNKAAGLRSLLCP

Specific function: Menaquinone biosynthesis. [C]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI87082077, Length=426, Percent_Identity=66.4319248826291, Blast_Score=563, Evalue=1e-162,
Organism=Escherichia coli, GI1786809, Length=345, Percent_Identity=26.6666666666667, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787518, Length=299, Percent_Identity=26.7558528428094, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 48758; Mature: 48758

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGFTTVEVCVLSVSTALARLQDGLGESFPDLPGTRIIDVAFPLNDAFDPLLWCGQQAQW
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCC
PQFYWQQRNGDEELATLGAVKTFTSLDAANRFLRQAGRQDLRICGLNAFEPQQGSLALPR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCC
LEWRRCGGRAVLRLVLHSDISLREDAATARAFLASLTTTQATPGAIPPLLSERHSSDYPQ
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHH
WQAMIARATKAISAGEMDKVVLARATDLQFAAPLDAVSIMAASRRSNLNCFHFLMAFNAR
HHHHHHHHHHHHCCCCCHHHHHEEECCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QAFFGSTPERLWRRRGALLRTEALAGTVANHQEDAKAQQLADWLMKDDKNQRENMLVVED
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCEEHHHH
ICQRLQSEASTLDVLPPQVVRLRKVQHLRRCIWTELAAPDDSRCLLQLQPTAAVAGLPRW
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCHH
AALAFIQRHEPFSREWYAGSAGYLSLAQSEFCVALRSAKVDHDTLRLYAGAGIVSGSDAQ
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCHH
QEWQEIDNKAAGLRSLLCP
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWGFTTVEVCVLSVSTALARLQDGLGESFPDLPGTRIIDVAFPLNDAFDPLLWCGQQAQW
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCC
PQFYWQQRNGDEELATLGAVKTFTSLDAANRFLRQAGRQDLRICGLNAFEPQQGSLALPR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCC
LEWRRCGGRAVLRLVLHSDISLREDAATARAFLASLTTTQATPGAIPPLLSERHSSDYPQ
HHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHH
WQAMIARATKAISAGEMDKVVLARATDLQFAAPLDAVSIMAASRRSNLNCFHFLMAFNAR
HHHHHHHHHHHHCCCCCHHHHHEEECCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QAFFGSTPERLWRRRGALLRTEALAGTVANHQEDAKAQQLADWLMKDDKNQRENMLVVED
HHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCEEHHHH
ICQRLQSEASTLDVLPPQVVRLRKVQHLRRCIWTELAAPDDSRCLLQLQPTAAVAGLPRW
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCHH
AALAFIQRHEPFSREWYAGSAGYLSLAQSEFCVALRSAKVDHDTLRLYAGAGIVSGSDAQ
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCHH
QEWQEIDNKAAGLRSLLCP
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8549818; 8764478; 9205837; 9278503; 2666397; 7984428 [H]