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The map label for this gene is nhaB [H]

Identifier: 238895371

GI number: 238895371

Start: 3259082

End: 3260851

Strand: Direct

Name: nhaB [H]

Synonym: KP1_3436

Alternate gene names: 238895371

Gene position: 3259082-3260851 (Clockwise)

Preceding gene: 238895369

Following gene: 238895372

Centisome position: 62.1

GC content: 59.6

Gene sequence:

>1770_bases
TTGCACTCATCATACCAGAGCCGCTATAGCGCAGATAGCATGGCAAGTGAATTAAAAAGGGATCGCCGTTTCATTTTCCG
CTTTTACTTTGCGCTTTTCCTTATCTTCACAAACCGCCAGCGCGGCGCGAAGAAAGTTGCTTCTCATTTTGCTCAACTGG
TACTCTTGCCAATCGTTATGCACAAAACCATGCACTCATTGACGGGGAAGGATTCTGTCGTGGAAATTTCTTATGGCCGC
GCGCTGTGGCGCAATTTTCTTGGCCAGTCGCCGGACTGGTACAAGCTGGCATTAATCATTTTCTTAATCGTAAATCCGCT
GGTGTTCGCCGTGGCGCCGTTTGTCGCCGGCTGGCTGCTGGTGGTTGAGTTTATCTTTACCCTCGCCATGGCGCTGAAGT
GCTATCCGCTGCTGCCGGGTGGTCTGCTGGCTATCGAGGCGCTGCTGATCGGCATGACCAGCCCGGCGCACGTCCGGGAC
GAGATCGCCGGCAATCTGGAGGTGCTGCTCCTGCTGATGTTCATGGTGGCGGGTATCTACTTTATGAAACAGCTTTTGCT
GTTCGTGTTTACGCGCCTGCTGCTGGGGATCCGCAGCAAAATGCTGCTATCGCTGGCCTTCTGCCTGGCGGCCGCCTTCC
TCTCGGCCTTTCTCGATGCGCTGACGGTGGTGGCGGTAGTGATCAGCGTCGCCGTCGGGTTCTACGGCATCTATCACCGC
GTCGCCTCGGCGCGCCCGGACGATAGCGACCTGCTCGATGACAGCCATATCGAGCAGCACTACCGCGAGGTGCTGGAGCA
GTTCCGCGGCTTTCTGCGCAGCCTGATGATGCACGCCGGCGTCGGGACCGCGCTCGGCGGCGTCATGACCATGGTCGGCG
AGCCGCAAAACCTGATTATCGCCAAAGCCGCGGGCTGGCATTTTGGCGAGTTCTTTCTTCGCATGGCGCCCGTGACCCTG
CCGGTGATGGTCTGCGGTCTGTTAACCTGTCTGCTGGTCGAAAAGTATCGCCTGTTTGGCTACGGCGAACCGCTACCGCC
GACGGTGCGCAAGGTGCTGCAGGAGTTTGACGATCGCAGCCGCGCCCAGCGCAGTCGTCAGGAGCGACTGCGGCTGATTG
CCCAGGCGCTCATTGGCATTTGGCTGATCGTGGCCCTGGCTTTTCACCTGGCTGAGGTCGGCCTGATTGGCCTGTCGGTG
ATCATCCTCGCCACCACCTTTACCGGCGTTACCGATGAGCACGCCATTGGCAAGGCGTTCACCGAGGCGCTGCCCTTTAC
CGCGCTGCTGACGGTCTTCTTCTCCATCGTCGCGGTTATCATCGATCAGCAGCTGTTCACGCCGGTCATCGAGTTTGTCC
TGCAGGCCTCGCCGCACGCGCAGCTGTCGCTGTTTTATCTGTTCAACGGCCTGCTGTCGTCCATTTCGGATAACGTGTTT
GTCGGCACGGTCTACATCAACGAAGCGAAAGCGGCGCTCGAACATGGCGCCATCAGCCTGCCCCAGTTTGAGATGCTGGC
GGTAGCGATCAACACCGGCACCAACCTGCCCTCGGTGGCCACCCCGAACGGCCAGGCGGCGTTTCTCTTCCTGCTGACTT
CCGCCCTGGCGCCGCTTATTAGGCTCTCCTATGGCCGTATGGTGTGGATGGCGCTGCCCTACACCATCGTACTGACGCTG
GTCGGCCTGTTATGCGTCGAGTTCACCCTGATGCCAGTCACCGACTGGCTGCTGGCGCACGGCTGGCTGGTGACGCCCAG
CCTGCCCTGA

Upstream 100 bases:

>100_bases
CGGTTATTCCAGATACTCTCAATGATGTACTCTTCCGCGAAACCCGCAGGGCTCTGCGCCTTAATGACCATAGTAAGATT
TCCATTACACAGCGTTACAA

Downstream 100 bases:

>100_bases
GTCAGTTTTTGCCCGGGTTCGCCCGGGCGCATCAATAACCCGTTACGGAATATTTTCCGCCGCGCCTCTGGCGTCGGTTC
GGTTTTCGTTTACACTGCCA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MHSSYQSRYSADSMASELKRDRRFIFRFYFALFLIFTNRQRGAKKVASHFAQLVLLPIVMHKTMHSLTGKDSVVEISYGR
ALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLPGGLLAIEALLIGMTSPAHVRD
EIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLDALTVVAVVISVAVGFYGIYHR
VASARPDDSDLLDDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGEFFLRMAPVTL
PVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIGIWLIVALAFHLAEVGLIGLSV
IILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPHAQLSLFYLFNGLLSSISDNVF
VGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTL
VGLLCVEFTLMPVTDWLLAHGWLVTPSLP

Sequences:

>Translated_589_residues
MHSSYQSRYSADSMASELKRDRRFIFRFYFALFLIFTNRQRGAKKVASHFAQLVLLPIVMHKTMHSLTGKDSVVEISYGR
ALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLPGGLLAIEALLIGMTSPAHVRD
EIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLDALTVVAVVISVAVGFYGIYHR
VASARPDDSDLLDDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGEFFLRMAPVTL
PVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIGIWLIVALAFHLAEVGLIGLSV
IILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPHAQLSLFYLFNGLLSSISDNVF
VGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTL
VGLLCVEFTLMPVTDWLLAHGWLVTPSLP
>Mature_589_residues
MHSSYQSRYSADSMASELKRDRRFIFRFYFALFLIFTNRQRGAKKVASHFAQLVLLPIVMHKTMHSLTGKDSVVEISYGR
ALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLPGGLLAIEALLIGMTSPAHVRD
EIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLDALTVVAVVISVAVGFYGIYHR
VASARPDDSDLLDDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGEFFLRMAPVTL
PVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIGIWLIVALAFHLAEVGLIGLSV
IILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPHAQLSLFYLFNGLLSSISDNVF
VGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTL
VGLLCVEFTLMPVTDWLLAHGWLVTPSLP

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=512, Percent_Identity=85.15625, Blast_Score=869, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 65260; Mature: 65260

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA