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The map label for this gene is ldh2 [H]

Identifier: 238894667

GI number: 238894667

Start: 2557283

End: 2558227

Strand: Reverse

Name: ldh2 [H]

Synonym: KP1_2672

Alternate gene names: 238894667

Gene position: 2558227-2557283 (Counterclockwise)

Preceding gene: 238894669

Following gene: 238894663

Centisome position: 48.74

GC content: 64.23

Gene sequence:

>945_bases
ATGCACACCAAAGCCCGTAAAGTGATGATTATTGGCGCCGGCAATGTCGGCGCGTCGGCGGCCTACGCCCTGCTCAACCA
GAGCATTTGCGAGGAGCTGATCCTCGTCGACCTTAACCAACAGCGCGCTGAGGCCCACGCTCAGGACCTGAGCGACGCCG
CGGCCTACCTGCCGGGGATGATGACCATCTCCACCCGCGAGGCCAGCGACTGCGCCGATGTCGATATCGCGGTGATCACC
GTCTCCGGCGGCGCGCTGCGCCCCGGCCAGAGCCGGCTGGATGAACTGACCTCCACCGCGAAGATTGTGAAGAGCATTGT
GCCGACGATGATGGCCAACGGATTTAAGGGCATCTTTCTGGTGGCCACCAACCCCTGCGACATCATCACCTGGCAGGTAT
GGCAGCTTTCCGGCCTGCCGCGCAGCCAGGTGCTGGGCACCGGCGTCTGGCTGGATACCACCCGCCTGCGTCGCCTGCTG
GCGCAGGAACTGGAGATTGGCGCCCAGAGCATCGACGCCTTTATCCTCGGCGAGCATGGCGATACCCAGTTTCCGGTGTG
GTCGCACTCCTCGGTATATGGCACGCCAATCGCCGACCTCTACCAGCAGCGCACCGGCCTGCCGCTCGCTCGCGAGGCGA
TGGCTGACAAAGTGCGCAAGCTGGGATTTGAGATCTACGCGGGTAAAGGCTGCACCGAATATGGCGTGGCAGGGACCATC
GCCGAGATCTGCCGCAATATCTTCACCGGCAGCCACCGCGCGCTGGCGGTCTCCTGCATTCTTGACGGCGAGTACGGGGT
CAGCGGCGCGGCGGCTGGGGTGCCGGCGGTGCTGGCCCAGGGTGGCGTGAAGCAGATCATTGAACTGCAGCTGGCCGGCG
AAGAGCAGGCGAAGTTCAGCCAGTCGATCGCGGTGATCAAGGCCAATATCGCCCGTCTGCCCTGA

Upstream 100 bases:

>100_bases
TTCCCGACATAGCATTAACTTATATTGCCGCCCGCCTATTGCGCTAACCAACTGAAACACAGTAATTTTATCCCCTGCTG
TTCGTACTTGAGATCTGAAT

Downstream 100 bases:

>100_bases
CGGCAGCCTGCGAGTCAGTCGGCAATGATCAGCTGCGGGGAAAGGGTCTCCAGCGCCTCGCGGGTTTTATCCGGCAGGTG
GGCGTCGGTGACGATATCGG

Product: putative malate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MHTKARKVMIIGAGNVGASAAYALLNQSICEELILVDLNQQRAEAHAQDLSDAAAYLPGMMTISTREASDCADVDIAVIT
VSGGALRPGQSRLDELTSTAKIVKSIVPTMMANGFKGIFLVATNPCDIITWQVWQLSGLPRSQVLGTGVWLDTTRLRRLL
AQELEIGAQSIDAFILGEHGDTQFPVWSHSSVYGTPIADLYQQRTGLPLAREAMADKVRKLGFEIYAGKGCTEYGVAGTI
AEICRNIFTGSHRALAVSCILDGEYGVSGAAAGVPAVLAQGGVKQIIELQLAGEEQAKFSQSIAVIKANIARLP

Sequences:

>Translated_314_residues
MHTKARKVMIIGAGNVGASAAYALLNQSICEELILVDLNQQRAEAHAQDLSDAAAYLPGMMTISTREASDCADVDIAVIT
VSGGALRPGQSRLDELTSTAKIVKSIVPTMMANGFKGIFLVATNPCDIITWQVWQLSGLPRSQVLGTGVWLDTTRLRRLL
AQELEIGAQSIDAFILGEHGDTQFPVWSHSSVYGTPIADLYQQRTGLPLAREAMADKVRKLGFEIYAGKGCTEYGVAGTI
AEICRNIFTGSHRALAVSCILDGEYGVSGAAAGVPAVLAQGGVKQIIELQLAGEEQAKFSQSIAVIKANIARLP
>Mature_314_residues
MHTKARKVMIIGAGNVGASAAYALLNQSICEELILVDLNQQRAEAHAQDLSDAAAYLPGMMTISTREASDCADVDIAVIT
VSGGALRPGQSRLDELTSTAKIVKSIVPTMMANGFKGIFLVATNPCDIITWQVWQLSGLPRSQVLGTGVWLDTTRLRRLL
AQELEIGAQSIDAFILGEHGDTQFPVWSHSSVYGTPIADLYQQRTGLPLAREAMADKVRKLGFEIYAGKGCTEYGVAGTI
AEICRNIFTGSHRALAVSCILDGEYGVSGAAAGVPAVLAQGGVKQIIELQLAGEEQAKFSQSIAVIKANIARLP

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=300, Percent_Identity=31, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI221136809, Length=300, Percent_Identity=31, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI15082234, Length=299, Percent_Identity=29.4314381270903, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI5031857, Length=305, Percent_Identity=28.5245901639344, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI260099723, Length=305, Percent_Identity=28.5245901639344, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI9257228, Length=300, Percent_Identity=30, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4504973, Length=300, Percent_Identity=30, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI291575128, Length=302, Percent_Identity=29.8013245033113, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4557032, Length=302, Percent_Identity=29.8013245033113, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI260099725, Length=200, Percent_Identity=31, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI260099727, Length=200, Percent_Identity=31, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI207028494, Length=217, Percent_Identity=29.0322580645161, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI103472011, Length=300, Percent_Identity=24.3333333333333, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI103472015, Length=183, Percent_Identity=27.3224043715847, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535107, Length=295, Percent_Identity=29.8305084745763, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45550422, Length=303, Percent_Identity=27.3927392739274, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136226, Length=309, Percent_Identity=28.1553398058252, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33370; Mature: 33370

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTKARKVMIIGAGNVGASAAYALLNQSICEELILVDLNQQRAEAHAQDLSDAAAYLPGM
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
MTISTREASDCADVDIAVITVSGGALRPGQSRLDELTSTAKIVKSIVPTMMANGFKGIFL
EEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VATNPCDIITWQVWQLSGLPRSQVLGTGVWLDTTRLRRLLAQELEIGAQSIDAFILGEHG
EECCCCCEEEEEEEEECCCCHHHHHCCCEEECHHHHHHHHHHHHHHCHHHCCEEEEECCC
DTQFPVWSHSSVYGTPIADLYQQRTGLPLAREAMADKVRKLGFEIYAGKGCTEYGVAGTI
CCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCHHCHHHHH
AEICRNIFTGSHRALAVSCILDGEYGVSGAAAGVPAVLAQGGVKQIIELQLAGEEQAKFS
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCHHHHHH
QSIAVIKANIARLP
HHHHHHHHHHHCCC
>Mature Secondary Structure
MHTKARKVMIIGAGNVGASAAYALLNQSICEELILVDLNQQRAEAHAQDLSDAAAYLPGM
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
MTISTREASDCADVDIAVITVSGGALRPGQSRLDELTSTAKIVKSIVPTMMANGFKGIFL
EEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VATNPCDIITWQVWQLSGLPRSQVLGTGVWLDTTRLRRLLAQELEIGAQSIDAFILGEHG
EECCCCCEEEEEEEEECCCCHHHHHCCCEEECHHHHHHHHHHHHHHCHHHCCEEEEECCC
DTQFPVWSHSSVYGTPIADLYQQRTGLPLAREAMADKVRKLGFEIYAGKGCTEYGVAGTI
CCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCHHCHHHHH
AEICRNIFTGSHRALAVSCILDGEYGVSGAAAGVPAVLAQGGVKQIIELQLAGEEQAKFS
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCHHHHHH
QSIAVIKANIARLP
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]