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The map label for this gene is 4hbD [H]

Identifier: 238894663

GI number: 238894663

Start: 2552968

End: 2554116

Strand: Reverse

Name: 4hbD [H]

Synonym: KP1_2668

Alternate gene names: 238894663

Gene position: 2554116-2552968 (Counterclockwise)

Preceding gene: 238894667

Following gene: 238894662

Centisome position: 48.66

GC content: 62.84

Gene sequence:

>1149_bases
GTGGCGACGATACACAGCACAATCATCAGCGGGGCTGGCGCCTCATCGGCCCTGCTCCCGCTGCTGGCCGGTAAAACCTC
AATCCTGCTGGTGACCGACAAGAACGTCGGGGCGCTGGAGGCAACCCAGGCGATTCATCGCCTGCTGGCGGCTGAAGGGC
GTGAAGTTGAGGTCATTGACAGCGTGCCAGCGGAGCCCAACCATCACGATGTTACGCAGATCGTCAGCCAGCTGGGCGCC
AGCCAGCCGCAGATGGTCGTTGGTATCGGCGGGGGGAGCGTACTGGATGTAGCAAAACTGCTGTCAGTACTTCTGCACCC
TGAGGCGCCCTCGCTGACGTCCCTGCTGGCAGGCGAGCAGCCGCAACGACGAATTTGCTCATTGTTAATCCCGGCCACCG
CGGGCACCGGATCCGAAGCGACGCCGAACGCCATTCTGGCGATCCCCGAGCAGCAGACGAAGGTGGGGATCATCTCCCCG
GTGCTGCTTCCGGACTATGTCGCCCTGCTGCCGGAGCTGACCACCAGCATGCCGCCCAGCATCGCGGCGTCGACCGGAAT
CGATGCTCTGTGTCATCTGCTGGAGTGCTTTACCTCCACCGTCGCCAACCCGGTGAGCGATAACGCGGCGTTAATCGGTT
TACACAAGCTGGTACGCCATATCGAGCGTTCGGTAAATCAGCCGCAGGATCTGACGGCGAAGCTGGAGATGCTCTGGGCC
TCGTGGTACGGCGGCGCAGCGATCAACTATTCCGGCACTCACCTGGTGCATGCGCTCTCCTATCCGCTTGGCGGTACCTG
GCACCTGCCGCACGGGGTGGCCAACGCCATTCTACTGGCGCCCTGCATGCGGGTGGTCCGCCCTCACGCGGTGGCGAAGT
TCGCTCAAGTCTGGGACCTGATCCCCGATGCAGATCGCACGCTCAGCGCGGAAGAGAAATCCCATGCGCTGGTCGCATGG
CTGGCGGCGCTGGTCAAACGACTGCCGCTGCCGGACAACCTGGCCGCGCTAGGCGTGCCTCAGGAGAGTATTTCCGCCCT
CAGCGCAGCGGCGCAAAACGTCAAACGCCTGATGAACAATGCCCCATGCAGCGTCAGCCGCGAAGAGATCGCGGCCATCT
ACCAAACGCTGTATCCAGAACATGCCTAA

Upstream 100 bases:

>100_bases
AGTTATTAAGCTGCCGTATAAATTATAACTTTTCCCCATCAGACGAGTGGCAAGATTTATGAATGATTGAATTCAATCAA
TTACTACCAAGGAGAAACGC

Downstream 100 bases:

>100_bases
CAGGAGAAAGTTAAATGAGGAAAGCTATTAGCGGCGTACTCACCGCCATTGTCACTCCCTTTACCGCCGAGGGAGCGCTT
AACCTGCCGGCGCTACGCCA

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: 4HBD [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MATIHSTIISGAGASSALLPLLAGKTSILLVTDKNVGALEATQAIHRLLAAEGREVEVIDSVPAEPNHHDVTQIVSQLGA
SQPQMVVGIGGGSVLDVAKLLSVLLHPEAPSLTSLLAGEQPQRRICSLLIPATAGTGSEATPNAILAIPEQQTKVGIISP
VLLPDYVALLPELTTSMPPSIAASTGIDALCHLLECFTSTVANPVSDNAALIGLHKLVRHIERSVNQPQDLTAKLEMLWA
SWYGGAAINYSGTHLVHALSYPLGGTWHLPHGVANAILLAPCMRVVRPHAVAKFAQVWDLIPDADRTLSAEEKSHALVAW
LAALVKRLPLPDNLAALGVPQESISALSAAAQNVKRLMNNAPCSVSREEIAAIYQTLYPEHA

Sequences:

>Translated_382_residues
MATIHSTIISGAGASSALLPLLAGKTSILLVTDKNVGALEATQAIHRLLAAEGREVEVIDSVPAEPNHHDVTQIVSQLGA
SQPQMVVGIGGGSVLDVAKLLSVLLHPEAPSLTSLLAGEQPQRRICSLLIPATAGTGSEATPNAILAIPEQQTKVGIISP
VLLPDYVALLPELTTSMPPSIAASTGIDALCHLLECFTSTVANPVSDNAALIGLHKLVRHIERSVNQPQDLTAKLEMLWA
SWYGGAAINYSGTHLVHALSYPLGGTWHLPHGVANAILLAPCMRVVRPHAVAKFAQVWDLIPDADRTLSAEEKSHALVAW
LAALVKRLPLPDNLAALGVPQESISALSAAAQNVKRLMNNAPCSVSREEIAAIYQTLYPEHA
>Mature_381_residues
ATIHSTIISGAGASSALLPLLAGKTSILLVTDKNVGALEATQAIHRLLAAEGREVEVIDSVPAEPNHHDVTQIVSQLGAS
QPQMVVGIGGGSVLDVAKLLSVLLHPEAPSLTSLLAGEQPQRRICSLLIPATAGTGSEATPNAILAIPEQQTKVGIISPV
LLPDYVALLPELTTSMPPSIAASTGIDALCHLLECFTSTVANPVSDNAALIGLHKLVRHIERSVNQPQDLTAKLEMLWAS
WYGGAAINYSGTHLVHALSYPLGGTWHLPHGVANAILLAPCMRVVRPHAVAKFAQVWDLIPDADRTLSAEEKSHALVAWL
AALVKRLPLPDNLAALGVPQESISALSAAAQNVKRLMNNAPCSVSREEIAAIYQTLYPEHA

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=391, Percent_Identity=25.8312020460358, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789163, Length=380, Percent_Identity=28.6842105263158, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082107, Length=351, Percent_Identity=29.6296296296296, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787493, Length=368, Percent_Identity=28.2608695652174, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=26.984126984127, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789386, Length=357, Percent_Identity=23.8095238095238, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537053, Length=402, Percent_Identity=29.1044776119403, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=359, Percent_Identity=30.08356545961, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24657991, Length=410, Percent_Identity=25.8536585365854, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.61 [H]

Molecular weight: Translated: 40147; Mature: 40016

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIHSTIISGAGASSALLPLLAGKTSILLVTDKNVGALEATQAIHRLLAAEGREVEVID
CCCHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
SVPAEPNHHDVTQIVSQLGASQPQMVVGIGGGSVLDVAKLLSVLLHPEAPSLTSLLAGEQ
CCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PQRRICSLLIPATAGTGSEATPNAILAIPEQQTKVGIISPVLLPDYVALLPELTTSMPPS
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
IAASTGIDALCHLLECFTSTVANPVSDNAALIGLHKLVRHIERSVNQPQDLTAKLEMLWA
HHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SWYGGAAINYSGTHLVHALSYPLGGTWHLPHGVANAILLAPCMRVVRPHAVAKFAQVWDL
HHCCCEEECCCCHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPDADRTLSAEEKSHALVAWLAALVKRLPLPDNLAALGVPQESISALSAAAQNVKRLMNN
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
APCSVSREEIAAIYQTLYPEHA
CCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATIHSTIISGAGASSALLPLLAGKTSILLVTDKNVGALEATQAIHRLLAAEGREVEVID
CCHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
SVPAEPNHHDVTQIVSQLGASQPQMVVGIGGGSVLDVAKLLSVLLHPEAPSLTSLLAGEQ
CCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCC
PQRRICSLLIPATAGTGSEATPNAILAIPEQQTKVGIISPVLLPDYVALLPELTTSMPPS
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
IAASTGIDALCHLLECFTSTVANPVSDNAALIGLHKLVRHIERSVNQPQDLTAKLEMLWA
HHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SWYGGAAINYSGTHLVHALSYPLGGTWHLPHGVANAILLAPCMRVVRPHAVAKFAQVWDL
HHCCCEEECCCCHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPDADRTLSAEEKSHALVAWLAALVKRLPLPDNLAALGVPQESISALSAAAQNVKRLMNN
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
APCSVSREEIAAIYQTLYPEHA
CCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]