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The map label for this gene is phoP [H]

Identifier: 238894177

GI number: 238894177

Start: 2081389

End: 2082102

Strand: Reverse

Name: phoP [H]

Synonym: KP1_2137

Alternate gene names: 238894177

Gene position: 2082102-2081389 (Counterclockwise)

Preceding gene: 238894180

Following gene: 238894176

Centisome position: 39.67

GC content: 59.38

Gene sequence:

>714_bases
ATGAGCGTCAGACTACTATCGAAAATGCTAGGGAGAACAGCCATGCGCGTACTCGTGGTTGAGGATAATGCCCTGCTGCG
TCACCACCTCAAAGTTCAGCTGCAGGAGCTGGGCCATCAGGTCGATGCGGCGGAAGATGCCAGGGAAGCGGACTACTATC
TGGGCGAACATCTCCCGGATATCGCCATCGTCGATCTCGGCCTGCCGGATGAAGACGGTTTATCACTGATCCGCCGCTGG
CGCAGCCACGACGTGTCGCTGCCGGTGCTGGTGCTGACCGCCCGCGAAGGATGGCAGGATAAAGTGGAAGTGCTGAGCGC
CGGGGCGGATGATTACGTCACCAAGCCTTTCCATATTGAAGAGGTTGCCGCCCGCATGCAGGCGCTGCTGCGCCGTAACA
GCGGCCTGGCCTCGCAGGTGATCTCCCTGCCGCCGTTCCAGGTCGACCTCTCCCGGCGCGAGCTGTCGGTGAATGACCAG
CCGATCAAGCTGACCGCCTTTGAATACACCATTATGGAAACCCTGATCCGTAACCGCGGCAAAGTGGTCAGCAAAGATTC
GCTGATGCTCCAGCTTTACCCGGATGCCGAACTGCGAGAAAGCCACACCATCGACGTGCTGATGGGTCGGCTGCGCAAGA
AAATTCAGGCTGAATACCCACAGGACGTCATCACCACGGTGCGCGGCCAGGGCTATCTGTTCGAACTGCGCTGA

Upstream 100 bases:

>100_bases
TATGCGCAAAGGGCGCCGCCGAATGCTGGCCAGCCCGGGGCACCAGGGGCCCTTTTTATAAAAAGCTTTATTTAACAGCC
GTTTATATTTTGCGTATATA

Downstream 100 bases:

>100_bases
TGAAGGGACTGTTGCGGCATATCTTCCCGCTGTCATTACGGGTTCGCTTCCTGCTGGCGACCGCCGGGGTGGTGCTGGTG
CTCTCCCTGGCCTACGGCAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSVRLLSKMLGRTAMRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPDIAIVDLGLPDEDGLSLIRRW
RSHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQ
PIKLTAFEYTIMETLIRNRGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR

Sequences:

>Translated_237_residues
MSVRLLSKMLGRTAMRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPDIAIVDLGLPDEDGLSLIRRW
RSHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQ
PIKLTAFEYTIMETLIRNRGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR
>Mature_236_residues
SVRLLSKMLGRTAMRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPDIAIVDLGLPDEDGLSLIRRWR
SHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIEEVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQP
IKLTAFEYTIMETLIRNRGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=91.9282511210762, Blast_Score=422, Evalue=1e-120,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=37.1559633027523, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=36.1607142857143, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.5263157894737, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=34.8017621145374, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=33.0396475770925, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=36.5296803652968, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30.4545454545455, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.5676855895196, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.8385650224215, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=29.8701298701299, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=31.9327731092437, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.9622641509434, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26977; Mature: 26845

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRLLSKMLGRTAMRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPD
CCHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
IAIVDLGLPDEDGLSLIRRWRSHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIE
EEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHH
EVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQPIKLTAFEYTIMETLIRNRG
HHHHHHHHHHHHCCCHHHHHHCCCCCEEECCHHCCCCCCCCEEEEHHHHHHHHHHHHCCC
KVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR
CEEECCCEEEEECCCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
SVRLLSKMLGRTAMRVLVVEDNALLRHHLKVQLQELGHQVDAAEDAREADYYLGEHLPD
CHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
IAIVDLGLPDEDGLSLIRRWRSHDVSLPVLVLTAREGWQDKVEVLSAGADDYVTKPFHIE
EEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHH
EVAARMQALLRRNSGLASQVISLPPFQVDLSRRELSVNDQPIKLTAFEYTIMETLIRNRG
HHHHHHHHHHHHCCCHHHHHHCCCCCEEECCHHCCCCCCCCEEEEHHHHHHHHHHHHCCC
KVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAEYPQDVITTVRGQGYLFELR
CEEECCCEEEEECCCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA