| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is purB [H]
Identifier: 238894180
GI number: 238894180
Start: 2083650
End: 2085020
Strand: Reverse
Name: purB [H]
Synonym: KP1_2140
Alternate gene names: 238894180
Gene position: 2085020-2083650 (Counterclockwise)
Preceding gene: 238894181
Following gene: 238894177
Centisome position: 39.73
GC content: 56.53
Gene sequence:
>1371_bases ATGGAATTATCCTCACTGACCGCCGTTTCCCCTGTAGACGGCCGCTACGGCGATAAAGTCAGCGCGCTGCGCGGTATCTT CAGCGAATTCGGTTTGCTGAAATTCCGCGTTCAGGTGGAAGTACGTTGGCTGCAAAAACTGGCCGCCCACGCAGCGATCA AGGAAGTTCCTGCTTTTGCTGCCGACGCAAACGGTTTCCTTGATAAAATCGTCGCCGATTTCAGCGTTGAAGACGCGGAG CGCATCAAAACCATCGAGCGCACCACTAACCACGACGTGAAAGCGGTAGAGTATTTCCTGAAAGAGAAAGTCGCTGACGT CGCCGAGCTGCACGCGGTATCAGAGTTTATTCACTTCGCCTGTACGTCTGAAGACATCAATAACCTCTCCCACGCGCTGA TGCTGAAAACCGCCCGCGACGAAGTGGTTCTGCCTTACTGGCGCAAACTGATTGACGCGGTAAAAGATCTGGCGACCCAG TATCGCGATGTGCCGCTGCTCTCCCGTACCCACGGCCAGCCGGCAACGCCGTCCACCATGGGTAAAGAGATGGCGAACGT CGCCTACCGTATGGAGCGCCAGTATCGTCAACTGAACCAGGTGGAAATCCTCGGTAAAATCAACGGCGCGGTGGGTAACT ACAACGCCCACATCGCCGCCTACCCGGAAGTCGACTGGCATCAGTTCAGCGAAGAGTTCGTTACCTCGCTGGGTATTCAG TGGAACCCGTACACCACGCAGATCGAGCCGCATGACTATATCGCTGAGCTGTTTGACTGCATCGCGCGCTTCAACACCAT TCTGATCGACTTCGATCGCGACGTGTGGGGCTACATCGCGCTCAACCACTTCAAACAGAAGACCATCGCCGGGGAAATCG GCTCCTCCACCATGCCGCACAAGGTGAACCCGATTGACTTCGAAAACTCCGAAGGCAATCTCGGCCTGGCCAATGCGGTC ATGCAGCACCTGGCCAGCAAACTGCCGGTTTCCCGCTGGCAGCGCGACCTGACCGACTCCACCGTTCTGCGTAACCTCGG CGTGGGCATCGGCTATGCGCTGATCGCCTATCAGTCCACCCTCAAAGGGATCAGCAAGCTGGAGCTGAACCAGGATCGCC TGCTGGACGAACTGGATCACAACTGGGAAGTACTGGCTGAGCCGATCCAGACCGTGATGCGTCGTTACGGTATCGAAAAA CCGTACGAGAAGCTGAAAGAGCTGACCCGCGGCAAACGCGTGGACGCGGAAGGGATGAAGCAGTTTATTGACAGCCTCGC CCTGCCGGAAGAGGAAAAAGTGCGTCTCAAAGCGATGACCCCGGCCAACTATATCGGTCGGGCAACCACCATGGTTGACG AGCTGAAGTAA
Upstream 100 bases:
>100_bases TCAGGTGGGCGGCGGACGTCTGCAGCTTATGTTTTCCCGTAATCGTCTGGTTAACCAGGCAAAGCAAATTCTTGCTCATT TAACCCCGGAGTTGTGATCT
Downstream 100 bases:
>100_bases TCGCCCTGCCCCTCTTTCCGCCGGAAAGAGGGGCGTTTTATCGCCGGAAAGCGATCAGATCCAAACGTCGTTCACCGCCG TCCGCTCGCCGCCCTCGTGG
Product: adenylosuccinate lyase
Products: NA
Alternate protein names: ASL; Adenylosuccinase; ASase [H]
Number of amino acids: Translated: 456; Mature: 456
Protein sequence:
>456_residues MELSSLTAVSPVDGRYGDKVSALRGIFSEFGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADANGFLDKIVADFSVEDAE RIKTIERTTNHDVKAVEYFLKEKVADVAELHAVSEFIHFACTSEDINNLSHALMLKTARDEVVLPYWRKLIDAVKDLATQ YRDVPLLSRTHGQPATPSTMGKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQ WNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAV MQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGISKLELNQDRLLDELDHNWEVLAEPIQTVMRRYGIEK PYEKLKELTRGKRVDAEGMKQFIDSLALPEEEKVRLKAMTPANYIGRATTMVDELK
Sequences:
>Translated_456_residues MELSSLTAVSPVDGRYGDKVSALRGIFSEFGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADANGFLDKIVADFSVEDAE RIKTIERTTNHDVKAVEYFLKEKVADVAELHAVSEFIHFACTSEDINNLSHALMLKTARDEVVLPYWRKLIDAVKDLATQ YRDVPLLSRTHGQPATPSTMGKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQ WNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAV MQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGISKLELNQDRLLDELDHNWEVLAEPIQTVMRRYGIEK PYEKLKELTRGKRVDAEGMKQFIDSLALPEEEKVRLKAMTPANYIGRATTMVDELK >Mature_456_residues MELSSLTAVSPVDGRYGDKVSALRGIFSEFGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADANGFLDKIVADFSVEDAE RIKTIERTTNHDVKAVEYFLKEKVADVAELHAVSEFIHFACTSEDINNLSHALMLKTARDEVVLPYWRKLIDAVKDLATQ YRDVPLLSRTHGQPATPSTMGKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQ WNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAV MQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGISKLELNQDRLLDELDHNWEVLAEPIQTVMRRYGIEK PYEKLKELTRGKRVDAEGMKQFIDSLALPEEEKVRLKAMTPANYIGRATTMVDELK
Specific function: De novo purine biosynthesis; eighth step. [C]
COG id: COG0015
COG function: function code F; Adenylosuccinate lyase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily [H]
Homologues:
Organism=Escherichia coli, GI1787376, Length=456, Percent_Identity=94.0789473684211, Blast_Score=903, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013539 - InterPro: IPR000362 - InterPro: IPR020557 - InterPro: IPR008948 - InterPro: IPR022761 - InterPro: IPR004769 [H]
Pfam domain/function: PF08328 ASL_C; PF00206 Lyase_1 [H]
EC number: =4.3.2.2 [H]
Molecular weight: Translated: 51645; Mature: 51645
Theoretical pI: Translated: 5.93; Mature: 5.93
Prosite motif: PS00163 FUMARATE_LYASES
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MELSSLTAVSPVDGRYGDKVSALRGIFSEFGLLKFRVQVEVRWLQKLAAHAAIKEVPAFA CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHH ADANGFLDKIVADFSVEDAERIKTIERTTNHDVKAVEYFLKEKVADVAELHAVSEFIHFA CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CTSEDINNLSHALMLKTARDEVVLPYWRKLIDAVKDLATQYRDVPLLSRTHGQPATPSTM CCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHH GKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCC WNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPH CCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCC KVNPIDFENSEGNLGLANAVMQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQST CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH LKGISKLELNQDRLLDELDHNWEVLAEPIQTVMRRYGIEKPYEKLKELTRGKRVDAEGMK HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHH QFIDSLALPEEEKVRLKAMTPANYIGRATTMVDELK HHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCC >Mature Secondary Structure MELSSLTAVSPVDGRYGDKVSALRGIFSEFGLLKFRVQVEVRWLQKLAAHAAIKEVPAFA CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHH ADANGFLDKIVADFSVEDAERIKTIERTTNHDVKAVEYFLKEKVADVAELHAVSEFIHFA CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CTSEDINNLSHALMLKTARDEVVLPYWRKLIDAVKDLATQYRDVPLLSRTHGQPATPSTM CCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHH GKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCC WNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPH CCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCC KVNPIDFENSEGNLGLANAVMQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQST CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH LKGISKLELNQDRLLDELDHNWEVLAEPIQTVMRRYGIEKPYEKLKELTRGKRVDAEGMK HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHH QFIDSLALPEEEKVRLKAMTPANYIGRATTMVDELK HHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12471157 [H]