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The map label for this gene is phoQ [H]

Identifier: 238894176

GI number: 238894176

Start: 2079923

End: 2081389

Strand: Reverse

Name: phoQ [H]

Synonym: KP1_2136

Alternate gene names: 238894176

Gene position: 2081389-2079923 (Counterclockwise)

Preceding gene: 238894177

Following gene: 238894175

Centisome position: 39.66

GC content: 58.49

Gene sequence:

>1467_bases
ATGAAGGGACTGTTGCGGCATATCTTCCCGCTGTCATTACGGGTTCGCTTCCTGCTGGCGACCGCCGGGGTGGTGCTGGT
GCTCTCCCTGGCCTACGGCATGGTGGCCCTGGTGGGCTATAGCGTTAGCTTCGATAAAACCACCTTTCGCCTGCTGCGCG
GCGAGAGCAATCTCTTTTATATGCTGGCGAGATGGGAAAACGGCGCTATTGACGTCGACATCCCGGAAAACCTGAATATG
GAAAGCCCGACGGTGACCCTTATCTACGATGAGCAGGGCAAACTGCTGTGGGCGCAGCGTGATGTTCCATGGCTGGCGAA
ACGCATTCAACCGGAATGGCTGAAACGCAATGGCTTCCATGAGATTGAAGCCGATGTCGACAGCAGCAGTATGCTGTTGC
GCAATAACCATGAGATTCAGGAACAGCTGGACGCTATCCGCGAACAGGACGACGACTCTGAGATGACCCACTCGGTGGCG
ATCAACCTCTACCCGGCCACCAGCAAAATGCCTCAGCTCAGCATTGTGGTGGTCGACACCATTCCGGTGGAGCTCAAGCG
CAGCTATATGGTGTGGAGCTGGTTTGTCTATGTGCTGGCCGCCAACCTGCTGCTGGTGATCCCCCTGCTGTGGGTCGCCG
CCTGGTGGAGCCTGCGGCCCATTGAGTCGCTGGCCAAAGAGGTGCGCGAACTGGAGGAACATCACCGCGAAAAGCTCAAT
CCCAACACCACTCGCGAGCTGACCCGGCTGGTCAGCAACCTCAACCGCCTGGTTCGCAGCGAGCGCGAACGCTATGACAA
ATACCGCACTACCCTCACCGATCTCACTCACAGTCTGAAAACGCCGCTGGCGGTGATGCAGAGTACACTGCGCTCGCTGC
GCGGCGAGAAGATCAGCGTCGACGAGGCGGAGCCGGTGATGCTGGAGCAGATAAGCCGCATCTCGCAGCAGATTGGTTAT
TACCTGCATCGCGCCAGCATGCGCAGCGGCGGCACCCTCTTGAGCCGGGAATTACACCCGATCGCCCCCCTGCTTGACAG
CCTGACTTCCGCTCTCAACAAGGTCTATCAGCGCAAAGGGGTCAATATCTCGCTCGACATCTCGCCGGAGATCACTTTTG
TCGGCGAGCAGAACGATTTTATGGAAGTGATGGGTAACGTTCTTGATAACGCCTGTAAGTATTGTCTGGAGTTCGTGGAA
GTTTCCGTGCGCCAGACCACCGACAGCCATCTGCACATCCTGGTGGAAGACGATGGGCCGGGGATCCCGCAGAGCCAGCG
CCGGGCCGTTTTCGACCGCGGCCAGCGGGCTGATACCCTGCGTCCCGGCCAGGGGGTAGGGCTCTCCGTTGCGCGTGAAA
TTGTCGAACAATATGATGGAGAGATCATCGCCGGGGAAAGCCTGCTCGGCGGCGCCTGCATGGAGGTGGTGTTTGGCCGC
CAGCAGATGGAAGATAAACAGAGTTAA

Upstream 100 bases:

>100_bases
ACGTGCTGATGGGTCGGCTGCGCAAGAAAATTCAGGCTGAATACCCACAGGACGTCATCACCACGGTGCGCGGCCAGGGC
TATCTGTTCGAACTGCGCTG

Downstream 100 bases:

>100_bases
TCGTTGAGATTTTTCACGGCGCCTGCATCGCCAGGGCGCCGCATCCGTTATAATCCCTGTCAGACACCTGCAGTGGAATA
TCAATATGGATTATCAATTA

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKGLLRHIFPLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYMLARWENGAIDVDIPENLNM
ESPTVTLIYDEQGKLLWAQRDVPWLAKRIQPEWLKRNGFHEIEADVDSSSMLLRNNHEIQEQLDAIREQDDDSEMTHSVA
INLYPATSKMPQLSIVVVDTIPVELKRSYMVWSWFVYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
PNTTRELTRLVSNLNRLVRSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSLRGEKISVDEAEPVMLEQISRISQQIGY
YLHRASMRSGGTLLSRELHPIAPLLDSLTSALNKVYQRKGVNISLDISPEITFVGEQNDFMEVMGNVLDNACKYCLEFVE
VSVRQTTDSHLHILVEDDGPGIPQSQRRAVFDRGQRADTLRPGQGVGLSVAREIVEQYDGEIIAGESLLGGACMEVVFGR
QQMEDKQS

Sequences:

>Translated_488_residues
MKGLLRHIFPLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYMLARWENGAIDVDIPENLNM
ESPTVTLIYDEQGKLLWAQRDVPWLAKRIQPEWLKRNGFHEIEADVDSSSMLLRNNHEIQEQLDAIREQDDDSEMTHSVA
INLYPATSKMPQLSIVVVDTIPVELKRSYMVWSWFVYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
PNTTRELTRLVSNLNRLVRSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSLRGEKISVDEAEPVMLEQISRISQQIGY
YLHRASMRSGGTLLSRELHPIAPLLDSLTSALNKVYQRKGVNISLDISPEITFVGEQNDFMEVMGNVLDNACKYCLEFVE
VSVRQTTDSHLHILVEDDGPGIPQSQRRAVFDRGQRADTLRPGQGVGLSVAREIVEQYDGEIIAGESLLGGACMEVVFGR
QQMEDKQS
>Mature_488_residues
MKGLLRHIFPLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYMLARWENGAIDVDIPENLNM
ESPTVTLIYDEQGKLLWAQRDVPWLAKRIQPEWLKRNGFHEIEADVDSSSMLLRNNHEIQEQLDAIREQDDDSEMTHSVA
INLYPATSKMPQLSIVVVDTIPVELKRSYMVWSWFVYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
PNTTRELTRLVSNLNRLVRSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSLRGEKISVDEAEPVMLEQISRISQQIGY
YLHRASMRSGGTLLSRELHPIAPLLDSLTSALNKVYQRKGVNISLDISPEITFVGEQNDFMEVMGNVLDNACKYCLEFVE
VSVRQTTDSHLHILVEDDGPGIPQSQRRAVFDRGQRADTLRPGQGVGLSVAREIVEQYDGEIIAGESLLGGACMEVVFGR
QQMEDKQS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=486, Percent_Identity=81.8930041152263, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=24.9084249084249, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=29.5275590551181, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=257, Percent_Identity=28.7937743190661, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786783, Length=269, Percent_Identity=21.1895910780669, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=24.7148288973384, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55563; Mature: 55563

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLLRHIFPLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEE
MLARWENGAIDVDIPENLNMESPTVTLIYDEQGKLLWAQRDVPWLAKRIQPEWLKRNGFH
EEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHCCHHHHHCCCCC
EIEADVDSSSMLLRNNHEIQEQLDAIREQDDDSEMTHSVAINLYPATSKMPQLSIVVVDT
EEECCCCCCCHHHHCCHHHHHHHHHHHCCCCCHHHEEEEEEEEEECCCCCCCEEEEEEEC
IPVELKRSYMVWSWFVYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PNTTRELTRLVSNLNRLVRSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSLRGEKISV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECC
DEAEPVMLEQISRISQQIGYYLHRASMRSGGTLLSRELHPIAPLLDSLTSALNKVYQRKG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
VNISLDISPEITFVGEQNDFMEVMGNVLDNACKYCLEFVEVSVRQTTDSHLHILVEDDGP
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
GIPQSQRRAVFDRGQRADTLRPGQGVGLSVAREIVEQYDGEIIAGESLLGGACMEVVFGR
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QQMEDKQS
HHHHCCCC
>Mature Secondary Structure
MKGLLRHIFPLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEE
MLARWENGAIDVDIPENLNMESPTVTLIYDEQGKLLWAQRDVPWLAKRIQPEWLKRNGFH
EEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHCCHHHHHCCCCC
EIEADVDSSSMLLRNNHEIQEQLDAIREQDDDSEMTHSVAINLYPATSKMPQLSIVVVDT
EEECCCCCCCHHHHCCHHHHHHHHHHHCCCCCHHHEEEEEEEEEECCCCCCCEEEEEEEC
IPVELKRSYMVWSWFVYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PNTTRELTRLVSNLNRLVRSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSLRGEKISV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECC
DEAEPVMLEQISRISQQIGYYLHRASMRSGGTLLSRELHPIAPLLDSLTSALNKVYQRKG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
VNISLDISPEITFVGEQNDFMEVMGNVLDNACKYCLEFVEVSVRQTTDSHLHILVEDDGP
CEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
GIPQSQRRAVFDRGQRADTLRPGQGVGLSVAREIVEQYDGEIIAGESLLGGACMEVVFGR
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QQMEDKQS
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA