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The map label for this gene is mrdB [H]

Identifier: 238893701

GI number: 238893701

Start: 1562498

End: 1563610

Strand: Reverse

Name: mrdB [H]

Synonym: KP1_1621

Alternate gene names: 238893701

Gene position: 1563610-1562498 (Counterclockwise)

Preceding gene: 238893702

Following gene: 238893700

Centisome position: 29.79

GC content: 57.14

Gene sequence:

>1113_bases
ATGACGGATAATCCGAACAAAAAATCGCTATGGGATAAAATCCATCTTGACCCCACCATGCTGCTTATCCTGCTGGCGCT
GCTGACCTACAGCGCGCTGGTTATCTGGAGCGCCAGCGGTCAGGACGTCGGCATGATGGAGCGTAAAATCGGCCAGATCG
CCATGGGCGTGGTGATCATGATCGTCATGGCGCAGATCCCGCCGCGGGTCTATGAAGGCTGGGCGCCCTACCTCTATATT
TTCTGTATCATCCTGCTGGTAGCCGTTGACGCCTTCGGCGCCATCTCCAAAGGGGCGCAGCGCTGGCTGGATCTCGGTAT
TGTGCGCTTTCAGCCGTCGGAGATCGCCAAAATAGCCGTGCCGCTGATGGTGGCGCGGTTTATTAACCGCGATGTCTGTC
CACCGTCGCTGAAGAACACCGGCATTGCCCTGGTGCTAATCTTCCTGCCGACGCTGCTGGTGGCGGCGCAGCCTGACCTC
GGGACCTCGATCCTGATCGCCCTATCCGGGCTGTTTGTGCTGTTCCTCTCCGGCCTCAGCTGGCGCCTGATTGGTATCGC
CGTGGTGCTGGTCGCCGCCTTTATTCCGATCCTGTGGTTCTTCCTGATGCACGACTATCAGCGTCAGCGCGTGATGATGC
TCCTCGATCCGGAAACCGACCCGCTGGGCGCCGGCTATCACATTATTCAGTCTAAAATTGCCATTGGCTCCGGCGGTCTG
CGCGGCAAAGGCTGGCTGCACGGCACCCAGTCGCAGCTGGAGTTTCTGCCGGAACGCCACACCGACTTTATCTTCGCCGT
CCTCGCCGAAGAGCTGGGCCTGATTGGCGTACTGATCCTGCTAGCGCTTTATATTCTGCTGATTATGCGCGGACTGTGGA
TCGCCGCCCAGGCGCAAACCACCTTTGGCCGGGTCATGGCCGGTGGTTTAATGTTGATTTTATTCGTTTATGTCTTCGTA
AATATTGGTATGGTGAGTGGTATTTTACCGGTGGTGGGCGTACCGTTGCCGCTGGTGAGCTACGGGGGCTCCGCCCTGAT
CGTACTGATGGCCGGGTTTGGTATCGTAATGTCGATCCATACCCACAGAAAAATGTTGTCGAAAAGCGTTTAA

Upstream 100 bases:

>100_bases
GTACGATTATGCGCCAGATCCTCGATCACATCATGCTGGGCGATAACAACACTACGCTGCCAAGCGAAAACCCGGCGGTA
ACCGCAGGGGAGGATCAATA

Downstream 100 bases:

>100_bases
AGGGGTTAGCAATGCGTAAGCAATGGCTGGGGATCTGCATAGCAGCGGGGCTGCTGGCGGCATGTTCGAGTGATGACGTG
CAACAAAAAACGGTCAGTAC

Product: cell wall shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTDNPNKKSLWDKIHLDPTMLLILLALLTYSALVIWSASGQDVGMMERKIGQIAMGVVIMIVMAQIPPRVYEGWAPYLYI
FCIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFLPTLLVAAQPDL
GTSILIALSGLFVLFLSGLSWRLIGIAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
RGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLILLALYILLIMRGLWIAAQAQTTFGRVMAGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV

Sequences:

>Translated_370_residues
MTDNPNKKSLWDKIHLDPTMLLILLALLTYSALVIWSASGQDVGMMERKIGQIAMGVVIMIVMAQIPPRVYEGWAPYLYI
FCIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFLPTLLVAAQPDL
GTSILIALSGLFVLFLSGLSWRLIGIAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
RGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLILLALYILLIMRGLWIAAQAQTTFGRVMAGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV
>Mature_369_residues
TDNPNKKSLWDKIHLDPTMLLILLALLTYSALVIWSASGQDVGMMERKIGQIAMGVVIMIVMAQIPPRVYEGWAPYLYIF
CIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFLPTLLVAAQPDLG
TSILIALSGLFVLFLSGLSWRLIGIAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPETDPLGAGYHIIQSKIAIGSGGLR
GKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLILLALYILLIMRGLWIAAQAQTTFGRVMAGGLMLILFVYVFVN
IGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV

Specific function: This is one of the proteins responsible for the rod shape of E.coli. Is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=370, Percent_Identity=95.9459459459459, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1786277, Length=374, Percent_Identity=31.0160427807487, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40461; Mature: 40330

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNPNKKSLWDKIHLDPTMLLILLALLTYSALVIWSASGQDVGMMERKIGQIAMGVVIM
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
IVMAQIPPRVYEGWAPYLYIFCIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAV
HHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHH
PLMVARFINRDVCPPSLKNTGIALVLIFLPTLLVAAQPDLGTSILIALSGLFVLFLSGLS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
WRLIGIAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
RGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLILLALYILLIMRGLWIAAQAQT
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
THRKMLSKSV
HHHHHHHCCC
>Mature Secondary Structure 
TDNPNKKSLWDKIHLDPTMLLILLALLTYSALVIWSASGQDVGMMERKIGQIAMGVVIM
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
IVMAQIPPRVYEGWAPYLYIFCIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAV
HHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHH
PLMVARFINRDVCPPSLKNTGIALVLIFLPTLLVAAQPDLGTSILIALSGLFVLFLSGLS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
WRLIGIAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
RGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLILLALYILLIMRGLWIAAQAQT
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
THRKMLSKSV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]