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The map label for this gene is mrdA [H]

Identifier: 238893702

GI number: 238893702

Start: 1563610

End: 1565511

Strand: Reverse

Name: mrdA [H]

Synonym: KP1_1622

Alternate gene names: 238893702

Gene position: 1565511-1563610 (Counterclockwise)

Preceding gene: 238893703

Following gene: 238893701

Centisome position: 29.83

GC content: 58.41

Gene sequence:

>1902_bases
ATGAAATTACAGAATTCTTTCCGCGACTATACGGCTGAATCCTCGCTGTTCGTGCGCCGGGCGCTGGTCGCTTTTTTGGG
GATTTTGCTGCTTACCGGCGTTCTGATCGCCAACCTGTACAATGTGCAAATCGTTCGCTTCGACGACTATCAGACGCGCT
CGAACGAAAACCGCATCAAGCTGGTGCCGATCCCGCCGAGCCGCGGCATTATTTACGATCGCAACGGCACCCCGCTGGCG
CTTAACCGCACCATTTACCAGCTGGAGATGATGCCGGAGAAAGTCGATAACGTACAGCAGACGCTGGATGCGCTACGCGA
CGTCGTCGATTTAACCGACGATGACATCGCCGGTTTCAAAAAGGAGCGCGCCCGCTCCCATCGTTTTACCTCGATTCCGG
TAAAGGTCAACCTCAGCGAAGTGCAGGTGGCCCGCTTTGCCGTCAACCAGTACCGCTTTCCCGGCGTGGAAGTCAAAGGC
TACAAGCGTCGTTATTACCCCTATAATTCGGCGCTGACTCACGTCATTGGCTATGTCTCAAAAATTAACGATAAAGACGT
CGACCGCCTGGATAAAGAGGGCAAGCTGGCCAACTACGCCTCGACGCACGACATTGGTAAGCTGGGTATAGAGCGTTATT
ACGAGGACGTTCTGCACGGTCAGACCGGCTACGAAGAGGTTGAAGTGAACAACCGCGGCCGCGTCATTCGTCAGCTGAAA
GAGGTGCCTCCGCAGGCCGGACGCGACATTTACCTCACCCTCGACCTCAAGCTGCAGCAGTATATTGAAACGCTGCTGGC
CGGCAGCCGCGCCGCCGTGGTGGTGACCGACCCGCGTACCGGCGCTATTCTGGCGCTGGTTTCAACCCCGAGCTATGACC
CGAACCTGTTCGTCGACGGCATCTCCAGCAAAGATTACTCCGCGCTGCTCAACGACCCGAACACACCGCTGGTCAACCGA
GCGACGCAGGGGGTCTATCCCCCGGCGTCGACGGTCAAACCCTACGTCGCCGTCTCGGCGCTGAGCGCCGGGGTGATCAC
CCGCAACACCAGCCTCTTCGACCCCGGCTGGTGGCAGTTGCCCGGCTCAGAGAAACGCTATCGTGACTGGAAAAAGTGGG
GCCACGGCCATCTGAACGTCACCAAAGCGCTCGAGGAGTCTGCAGATACCTATTTCTACCAGGTCGCCTATGACATGGGC
ATCGACCGTCTCTCAGAGTGGATGAGCAAGTTTGGCTACGGCCACTACACCGGTATCGACCTCTCCGAGGAGCGCTCTGG
CAACATGCCGACCCGCGAATGGAAGCTCAAGCGCTTTAAGAAACCCTGGTACCAGGGGGACACCATTCCGGTGGGCATCG
GCCAGGGTTACTGGACCGCCACGCCGATCCAGATGAACAAAGCGCTGATGATCCTGATTAACGACGGCGTGGTGAAGGTG
CCTCATCTGCTGCAGAGCACCGTGGAAGACGGCAAGCCCGTACCCTGGGTCCAGCCCCATGAGCCGCCGGTAGGCGATAT
CCATTCCGGCTATTGGGAAATCGCCAAAGACGGCATGTACGGCGTGGCCAACCGCGGCAACGGCACCGCGCACAAATACT
TCGCCAGCGCGCCGTATAAAATCGCGGCCAAGTCAGGTACCGCTCAGGTGTTCGGCCTGAAGGCCAACGAAACCTATAAC
GCGCACCGGATCTCCGAGCGCTTGCGCGACCATAAACTGATGACAGCGTTTGCGCCTTATAACAACCCGCAGGTTGCCGT
GGCGATGATTCTGGAAAACGGCGGCGCCGGCCCGGCGGTCGGTACGATTATGCGCCAGATCCTCGATCACATCATGCTGG
GCGATAACAACACTACGCTGCCAAGCGAAAACCCGGCGGTAACCGCAGGGGAGGATCAATAA

Upstream 100 bases:

>100_bases
GCGCGTACTGGTGGCCGAGAGTCTGTACCGGGCGTGGAGCATCACCACCAACCACCCGTACCACCGTGAGTAATGATGAT
CAGGGTAGACTAAGCAGCGA

Downstream 100 bases:

>100_bases
TGACGGATAATCCGAACAAAAAATCGCTATGGGATAAAATCCATCTTGACCCCACCATGCTGCTTATCCTGCTGGCGCTG
CTGACCTACAGCGCGCTGGT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MKLQNSFRDYTAESSLFVRRALVAFLGILLLTGVLIANLYNVQIVRFDDYQTRSNENRIKLVPIPPSRGIIYDRNGTPLA
LNRTIYQLEMMPEKVDNVQQTLDALRDVVDLTDDDIAGFKKERARSHRFTSIPVKVNLSEVQVARFAVNQYRFPGVEVKG
YKRRYYPYNSALTHVIGYVSKINDKDVDRLDKEGKLANYASTHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGRDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGAILALVSTPSYDPNLFVDGISSKDYSALLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNVTKALEESADTYFYQVAYDMG
IDRLSEWMSKFGYGHYTGIDLSEERSGNMPTREWKLKRFKKPWYQGDTIPVGIGQGYWTATPIQMNKALMILINDGVVKV
PHLLQSTVEDGKPVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRGNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHRISERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAVGTIMRQILDHIMLGDNNTTLPSENPAVTAGEDQ

Sequences:

>Translated_633_residues
MKLQNSFRDYTAESSLFVRRALVAFLGILLLTGVLIANLYNVQIVRFDDYQTRSNENRIKLVPIPPSRGIIYDRNGTPLA
LNRTIYQLEMMPEKVDNVQQTLDALRDVVDLTDDDIAGFKKERARSHRFTSIPVKVNLSEVQVARFAVNQYRFPGVEVKG
YKRRYYPYNSALTHVIGYVSKINDKDVDRLDKEGKLANYASTHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGRDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGAILALVSTPSYDPNLFVDGISSKDYSALLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNVTKALEESADTYFYQVAYDMG
IDRLSEWMSKFGYGHYTGIDLSEERSGNMPTREWKLKRFKKPWYQGDTIPVGIGQGYWTATPIQMNKALMILINDGVVKV
PHLLQSTVEDGKPVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRGNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHRISERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAVGTIMRQILDHIMLGDNNTTLPSENPAVTAGEDQ
>Mature_633_residues
MKLQNSFRDYTAESSLFVRRALVAFLGILLLTGVLIANLYNVQIVRFDDYQTRSNENRIKLVPIPPSRGIIYDRNGTPLA
LNRTIYQLEMMPEKVDNVQQTLDALRDVVDLTDDDIAGFKKERARSHRFTSIPVKVNLSEVQVARFAVNQYRFPGVEVKG
YKRRYYPYNSALTHVIGYVSKINDKDVDRLDKEGKLANYASTHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGRDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGAILALVSTPSYDPNLFVDGISSKDYSALLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNVTKALEESADTYFYQVAYDMG
IDRLSEWMSKFGYGHYTGIDLSEERSGNMPTREWKLKRFKKPWYQGDTIPVGIGQGYWTATPIQMNKALMILINDGVVKV
PHLLQSTVEDGKPVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRGNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHRISERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAVGTIMRQILDHIMLGDNNTTLPSENPAVTAGEDQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=633, Percent_Identity=93.2069510268562, Blast_Score=1232, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=620, Percent_Identity=24.8387096774194, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70982; Mature: 70982

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQNSFRDYTAESSLFVRRALVAFLGILLLTGVLIANLYNVQIVRFDDYQTRSNENRIK
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEE
LVPIPPSRGIIYDRNGTPLALNRTIYQLEMMPEKVDNVQQTLDALRDVVDLTDDDIAGFK
EEECCCCCCEEECCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KERARSHRFTSIPVKVNLSEVQVARFAVNQYRFPGVEVKGYKRRYYPYNSALTHVIGYVS
HHHHHCCCEEECEEEEEHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHH
KINDKDVDRLDKEGKLANYASTHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
HCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
EVPPQAGRDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGAILALVSTPSYDPNLFVDG
HCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEC
ISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQL
CCCCCHHHHHCCCCCCHHHHCCCCCCCCHHCCCHHHHHHHHHCCEEECCCCCCCCCCEEC
PGSEKRYRDWKKWGHGHLNVTKALEESADTYFYQVAYDMGIDRLSEWMSKFGYGHYTGID
CCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHCCCCCEECCC
LSEERSGNMPTREWKLKRFKKPWYQGDTIPVGIGQGYWTATPIQMNKALMILINDGVVKV
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEEECCEEECCEEEEEEECCCCHH
PHLLQSTVEDGKPVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRGNGTAHKYFASAPYK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCHHEEECCCCEE
IAAKSGTAQVFGLKANETYNAHRISERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAV
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCHHH
GTIMRQILDHIMLGDNNTTLPSENPAVTAGEDQ
HHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLQNSFRDYTAESSLFVRRALVAFLGILLLTGVLIANLYNVQIVRFDDYQTRSNENRIK
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEE
LVPIPPSRGIIYDRNGTPLALNRTIYQLEMMPEKVDNVQQTLDALRDVVDLTDDDIAGFK
EEECCCCCCEEECCCCCCEEECCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KERARSHRFTSIPVKVNLSEVQVARFAVNQYRFPGVEVKGYKRRYYPYNSALTHVIGYVS
HHHHHCCCEEECEEEEEHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHH
KINDKDVDRLDKEGKLANYASTHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
HCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
EVPPQAGRDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGAILALVSTPSYDPNLFVDG
HCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEC
ISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQL
CCCCCHHHHHCCCCCCHHHHCCCCCCCCHHCCCHHHHHHHHHCCEEECCCCCCCCCCEEC
PGSEKRYRDWKKWGHGHLNVTKALEESADTYFYQVAYDMGIDRLSEWMSKFGYGHYTGID
CCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHCCCCCEECCC
LSEERSGNMPTREWKLKRFKKPWYQGDTIPVGIGQGYWTATPIQMNKALMILINDGVVKV
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEEECCEEECCEEEEEEECCCCHH
PHLLQSTVEDGKPVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRGNGTAHKYFASAPYK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCHHEEECCCCEE
IAAKSGTAQVFGLKANETYNAHRISERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAV
EEECCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCHHH
GTIMRQILDHIMLGDNNTTLPSENPAVTAGEDQ
HHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]