Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 238893259

GI number: 238893259

Start: 1102356

End: 1103609

Strand: Reverse

Name: proA [H]

Synonym: KP1_1132

Alternate gene names: 238893259

Gene position: 1103609-1102356 (Counterclockwise)

Preceding gene: 238893260

Following gene: 238893258

Centisome position: 21.03

GC content: 62.28

Gene sequence:

>1254_bases
ATGCTGGAACAAATGGGCATTGCCGCCAAAGCGGCCTCCTGGCAGCTGGCGTTACTCTCCAGCCGGGAAAAGAATCAGGT
ACTGGAAAAGATCGCCGATTATCTGGAAGCGCAGACCGACGATATTCTGCGCGCCAACGCGGAAGATTTAGCCGAAGCTC
GCGCCAATGGCCTGAGTGAAGCGATGCTCGATCGCCTCGCGCTGACCCCGGCGCGTCTGAGCGGCATCGCCAGCGATGTG
CGCCAGGTGTGCAATCTGGCCGATCCGGTCGGCCAGGTGATCGACGGCGGGCTGCTGGACAGCGGTCTGCGTATTGAACG
TCGCCGCGTCCCGCTGGGGGTGATTGGCGTGATTTATGAAGCGCGTCCTAACGTGACGGTCGACGTCGCCTCCCTGTGTC
TGAAAACCGGCAACGCGGCGATCCTGCGCGGCGGGAAAGAGACCTGGCGCACCAACGCCGCCACGGTGAAGGTGATCCAG
CAGGCGCTGCAGGAGTGCGGTCTGCCGGCCGCCGCAGTACAGGCTATCGAGAGCCCGGATCGCGCGCTGGTGGGCGAAAT
GCTGAAGATGGATAAATACATCGATATGCTGATCCCTCGCGGCGGCGCGGGCCTGCACAAGCTATGCCGTGAGCAGTCAA
CGATCCCGGTGATCACCGGCGGGATTGGCGTGTGCCATATTTTCGTTGATGAAACCGCCGAGATCGCCCCCGCGCTGAAG
ATCATCGTCAACGCCAAGACCCAGCGGCCGAGCACCTGCAATACCGTGGAAACGCTGCTGGTGCACCGCAACATCGCCGA
CACCTTCCTGCCGGCGTTAAGCAAGCAGATGGCCGAGAGCGGCGTCACCCTGCACGCCGCCCCTTCCGCCCTCCCCGCGC
TGCAAAACGGCCCTGCGAAGGTCGAGCCGGTGAAAGCGGAGCAGTATGACGACGAGTATCTGTCGCTGGATCTGAACGTC
AAAGTGGTGGCTGATATGGATGAGGCTATCGCCCATATCCGCGAACATGGCACCCAGCACTCCGACGCCATCCTGACCCG
CACCCTGCGTAACGCCAACCGCTTTATCAATGAAGTGGACTCTTCCGCGGTATATGTGAACGCCTCCACGCGCTTCACCG
ACGGCGGCCAGTTCGGCCTCGGCGCGGAAGTGGCGGTCAGCACCCAGAAGCTGCACGCCCGCGGCCCGATGGGGCTGGAA
GCGTTAACCACCTATAAGTGGATTGGTTTCGGCGACGATACCATTCGTGCGTAA

Upstream 100 bases:

>100_bases
GCCGGCCAGCACTCGCAGCAAATCGATGCCATTCTGGGCTATGAATACGGCCCGGTGGCCGTCCACCGCGATGATATGAT
CATCCGTTAAGGAGCTGAAA

Downstream 100 bases:

>100_bases
ATGAGAACGGGCGATGCAAAAATAGGCAGTTGATTCCACTGGCTATTGACGCATCGCCCGCTAAGTTCTAACCTTTTGCC
TCGTGATTCACCCTCGTGAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLEQMGIAAKAASWQLALLSSREKNQVLEKIADYLEAQTDDILRANAEDLAEARANGLSEAMLDRLALTPARLSGIASDV
RQVCNLADPVGQVIDGGLLDSGLRIERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVKVIQ
QALQECGLPAAAVQAIESPDRALVGEMLKMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDETAEIAPALK
IIVNAKTQRPSTCNTVETLLVHRNIADTFLPALSKQMAESGVTLHAAPSALPALQNGPAKVEPVKAEQYDDEYLSLDLNV
KVVADMDEAIAHIREHGTQHSDAILTRTLRNANRFINEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLE
ALTTYKWIGFGDDTIRA

Sequences:

>Translated_417_residues
MLEQMGIAAKAASWQLALLSSREKNQVLEKIADYLEAQTDDILRANAEDLAEARANGLSEAMLDRLALTPARLSGIASDV
RQVCNLADPVGQVIDGGLLDSGLRIERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVKVIQ
QALQECGLPAAAVQAIESPDRALVGEMLKMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDETAEIAPALK
IIVNAKTQRPSTCNTVETLLVHRNIADTFLPALSKQMAESGVTLHAAPSALPALQNGPAKVEPVKAEQYDDEYLSLDLNV
KVVADMDEAIAHIREHGTQHSDAILTRTLRNANRFINEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLE
ALTTYKWIGFGDDTIRA
>Mature_417_residues
MLEQMGIAAKAASWQLALLSSREKNQVLEKIADYLEAQTDDILRANAEDLAEARANGLSEAMLDRLALTPARLSGIASDV
RQVCNLADPVGQVIDGGLLDSGLRIERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVKVIQ
QALQECGLPAAAVQAIESPDRALVGEMLKMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDETAEIAPALK
IIVNAKTQRPSTCNTVETLLVHRNIADTFLPALSKQMAESGVTLHAAPSALPALQNGPAKVEPVKAEQYDDEYLSLDLNV
KVVADMDEAIAHIREHGTQHSDAILTRTLRNANRFINEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLE
ALTTYKWIGFGDDTIRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=417, Percent_Identity=36.4508393285372, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI21361368, Length=417, Percent_Identity=36.4508393285372, Blast_Score=270, Evalue=1e-72,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=86.5707434052758, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=37.3493975903614, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=37.3493975903614, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=38.6416861826698, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI21357643, Length=415, Percent_Identity=36.8674698795181, Blast_Score=274, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44770; Mature: 44770

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQMGIAAKAASWQLALLSSREKNQVLEKIADYLEAQTDDILRANAEDLAEARANGLSE
CCCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCHHH
AMLDRLALTPARLSGIASDVRQVCNLADPVGQVIDGGLLDSGLRIERRRVPLGVIGVIYE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCEEEEEEEEE
ARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVKVIQQALQECGLPAAAVQAIESPD
CCCCCCHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RALVGEMLKMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDETAEIAPALK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEEECCHHHHHHHHH
IIVNAKTQRPSTCNTVETLLVHRNIADTFLPALSKQMAESGVTLHAAPSALPALQNGPAK
HEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCC
VEPVKAEQYDDEYLSLDLNVKVVADMDEAIAHIREHGTQHSDAILTRTLRNANRFINEVD
CCCCCCCCCCCCEEEEEEEEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
SSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDDTIRA
CCEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEECCCHHCCC
>Mature Secondary Structure
MLEQMGIAAKAASWQLALLSSREKNQVLEKIADYLEAQTDDILRANAEDLAEARANGLSE
CCCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCHHH
AMLDRLALTPARLSGIASDVRQVCNLADPVGQVIDGGLLDSGLRIERRRVPLGVIGVIYE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCEEEEEEEEE
ARPNVTVDVASLCLKTGNAAILRGGKETWRTNAATVKVIQQALQECGLPAAAVQAIESPD
CCCCCCHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RALVGEMLKMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDETAEIAPALK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEEECCHHHHHHHHH
IIVNAKTQRPSTCNTVETLLVHRNIADTFLPALSKQMAESGVTLHAAPSALPALQNGPAK
HEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCC
VEPVKAEQYDDEYLSLDLNVKVVADMDEAIAHIREHGTQHSDAILTRTLRNANRFINEVD
CCCCCCCCCCCCEEEEEEEEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
SSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDDTIRA
CCEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA