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The map label for this gene is mprB [H]

Identifier: 238028832

GI number: 238028832

Start: 3753717

End: 3755111

Strand: Reverse

Name: mprB [H]

Synonym: bglu_1g32970

Alternate gene names: 238028832

Gene position: 3755111-3753717 (Counterclockwise)

Preceding gene: 238028833

Following gene: 238028831

Centisome position: 96.12

GC content: 70.82

Gene sequence:

>1395_bases
GTGACTGAACCGGCAAGCCGCGCGTGCGCCGGGCCGCGCTGGTATTCGAGCACGTTCCGGCTGTTCGTCCTCTACTCGGT
GATGTTCTCGCTGTCGGTGATGGTGCTGCTCGGCGTGATCGCCACGCAGATCACGCACGACATGAAGCGGGAGACGGACG
TGGTGATCGACTGGCAGATGATCTACTTCGATTCGATGGCCGACGCCGACCTGCCCGGCGCGATCCACCGGCGCCTCGAA
CACGAGCGCATGCACACCAACTACTACGGCCTGTTCGCGCCGGACGGCCGGCACCTGGCGGGCGACGTGCTCGAATTCCC
GGCGGGCCTCGCCACCGACCGCAGCGGCCAGACCCTCTCGCACACGCTGAAGATCGCCGGCGACGAGGTGGCGCCGGTGG
TGCGCGCGATGGCGAAGGTGCGTCCCAACGGCGACCGGCTGGTGCTGGCGCGCGACCTCACGCACATCCTGCGGATTCGC
GAGGCGATCATCAACGTGCTGATCGTGGGCGGCGTGCTCTGCTTCGGCGGCGGGCTCGGCGGCGGGCTCGCGCTGAGCGT
GCGGCAGATGCGGCGCATCAAGGCGATCCGCCAGGTCACGCAGCGCATCGCGCACGGCGACCTGGCCCAGCGCCTGCCGG
TGGGCGGGCGCGACGAGATCGACATGCTCTCGCACCTCGTCAACCACATGCTGGCCGAGGTCGAGCGGCTGATGCACGAG
GTGAAGGGCGTCTGCGACGGCATCGCCCACGACCTGCGCACGCCGCTGGCGCATGTCCACACGCTGCTCGCGCACGCGGC
CGAGCGCGCCGGCACCTATGACGACGCGGCGCTCGCGAGCCTCGTCTCGCGCGCCCGCAACGAGACCGACGCGCTGCTCG
GGCGCTTCCGCGCGATGCTGCGGATCGCCGAGATCGGCTCGCTGCAGCGCCGCGGCGGCTTCGCCGAGGTCGATCTCGAG
GCGCTCGTGACCGACGTGGGCGAGCTGTTCGAGCCGCTCGCCGAGAGCCGCGAGATCCGCTTCCAGGTGCGCACCGAGAA
GGTGAGCGCCGTGCATGGCGATCGCGCGCTGCTGTTCGAGGCGCTGACCAATCTGCTCGACAACGCGATCAAGTATTCGC
CGGCGGGCGGCAGCGTGCGGCTCGAGCTGTGGCAGCGCCTGCCGGGGCCGTGCATCGAGGTGATCGACGACGGCCCCGGC
ATCGCGCCCGACGAACGCGAGGCGGTGCTGCAGCACCGCTACCGCAGCCGCCGCACGGTCCACCTGGCGGGCTCCGGGCT
CGGCCTGAGCATCGTCTCGACGGTGCTCAACGTCCACGACTTCACGCTGCGCATCGGCGGCGCCGCGCCCGGCACGCGCG
TGACGATCGAGTGCTGGCCGAGGACGCTGGTATGA

Upstream 100 bases:

>100_bases
CACATGGGGCGCCTGCGCAGGAAGATCGATCCGCCCGACGCGCCGCCGATGATCCGCACCGTGCGCGGCGCCGGCTACAT
CCTTTCGTGAGCGGCCGATC

Downstream 100 bases:

>100_bases
GCGCGGCCGCCGATACCGGCACGCACCGGGCGCAGGGCCGCTGACCATGCGCATCCTGCTCGTCGGCTCGCGCCATCCCG
AGGCGTCGTGGCTGCACAAG

Product: Periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTEPASRACAGPRWYSSTFRLFVLYSVMFSLSVMVLLGVIATQITHDMKRETDVVIDWQMIYFDSMADADLPGAIHRRLE
HERMHTNYYGLFAPDGRHLAGDVLEFPAGLATDRSGQTLSHTLKIAGDEVAPVVRAMAKVRPNGDRLVLARDLTHILRIR
EAIINVLIVGGVLCFGGGLGGGLALSVRQMRRIKAIRQVTQRIAHGDLAQRLPVGGRDEIDMLSHLVNHMLAEVERLMHE
VKGVCDGIAHDLRTPLAHVHTLLAHAAERAGTYDDAALASLVSRARNETDALLGRFRAMLRIAEIGSLQRRGGFAEVDLE
ALVTDVGELFEPLAESREIRFQVRTEKVSAVHGDRALLFEALTNLLDNAIKYSPAGGSVRLELWQRLPGPCIEVIDDGPG
IAPDEREAVLQHRYRSRRTVHLAGSGLGLSIVSTVLNVHDFTLRIGGAAPGTRVTIECWPRTLV

Sequences:

>Translated_464_residues
MTEPASRACAGPRWYSSTFRLFVLYSVMFSLSVMVLLGVIATQITHDMKRETDVVIDWQMIYFDSMADADLPGAIHRRLE
HERMHTNYYGLFAPDGRHLAGDVLEFPAGLATDRSGQTLSHTLKIAGDEVAPVVRAMAKVRPNGDRLVLARDLTHILRIR
EAIINVLIVGGVLCFGGGLGGGLALSVRQMRRIKAIRQVTQRIAHGDLAQRLPVGGRDEIDMLSHLVNHMLAEVERLMHE
VKGVCDGIAHDLRTPLAHVHTLLAHAAERAGTYDDAALASLVSRARNETDALLGRFRAMLRIAEIGSLQRRGGFAEVDLE
ALVTDVGELFEPLAESREIRFQVRTEKVSAVHGDRALLFEALTNLLDNAIKYSPAGGSVRLELWQRLPGPCIEVIDDGPG
IAPDEREAVLQHRYRSRRTVHLAGSGLGLSIVSTVLNVHDFTLRIGGAAPGTRVTIECWPRTLV
>Mature_463_residues
TEPASRACAGPRWYSSTFRLFVLYSVMFSLSVMVLLGVIATQITHDMKRETDVVIDWQMIYFDSMADADLPGAIHRRLEH
ERMHTNYYGLFAPDGRHLAGDVLEFPAGLATDRSGQTLSHTLKIAGDEVAPVVRAMAKVRPNGDRLVLARDLTHILRIRE
AIINVLIVGGVLCFGGGLGGGLALSVRQMRRIKAIRQVTQRIAHGDLAQRLPVGGRDEIDMLSHLVNHMLAEVERLMHEV
KGVCDGIAHDLRTPLAHVHTLLAHAAERAGTYDDAALASLVSRARNETDALLGRFRAMLRIAEIGSLQRRGGFAEVDLEA
LVTDVGELFEPLAESREIRFQVRTEKVSAVHGDRALLFEALTNLLDNAIKYSPAGGSVRLELWQRLPGPCIEVIDDGPGI
APDEREAVLQHRYRSRRTVHLAGSGLGLSIVSTVLNVHDFTLRIGGAAPGTRVTIECWPRTLV

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=27.5092936802974, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=313, Percent_Identity=28.7539936102236, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789808, Length=371, Percent_Identity=25.3369272237197, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=28.3842794759825, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=328, Percent_Identity=28.9634146341463, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=269, Percent_Identity=27.1375464684015, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=337, Percent_Identity=25.8160237388724, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=24.6636771300448, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789403, Length=245, Percent_Identity=27.7551020408163, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51024; Mature: 50892

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPASRACAGPRWYSSTFRLFVLYSVMFSLSVMVLLGVIATQITHDMKRETDVVIDWQM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
IYFDSMADADLPGAIHRRLEHERMHTNYYGLFAPDGRHLAGDVLEFPAGLATDRSGQTLS
EEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHH
HTLKIAGDEVAPVVRAMAKVRPNGDRLVLARDLTHILRIREAIINVLIVGGVLCFGGGLG
HHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLALSVRQMRRIKAIRQVTQRIAHGDLAQRLPVGGRDEIDMLSHLVNHMLAEVERLMHE
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VKGVCDGIAHDLRTPLAHVHTLLAHAAERAGTYDDAALASLVSRARNETDALLGRFRAML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
RIAEIGSLQRRGGFAEVDLEALVTDVGELFEPLAESREIRFQVRTEKVSAVHGDRALLFE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHH
ALTNLLDNAIKYSPAGGSVRLELWQRLPGPCIEVIDDGPGIAPDEREAVLQHRYRSRRTV
HHHHHHHHHHEECCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCEE
HLAGSGLGLSIVSTVLNVHDFTLRIGGAAPGTRVTIECWPRTLV
EEECCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
TEPASRACAGPRWYSSTFRLFVLYSVMFSLSVMVLLGVIATQITHDMKRETDVVIDWQM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
IYFDSMADADLPGAIHRRLEHERMHTNYYGLFAPDGRHLAGDVLEFPAGLATDRSGQTLS
EEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHH
HTLKIAGDEVAPVVRAMAKVRPNGDRLVLARDLTHILRIREAIINVLIVGGVLCFGGGLG
HHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLALSVRQMRRIKAIRQVTQRIAHGDLAQRLPVGGRDEIDMLSHLVNHMLAEVERLMHE
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VKGVCDGIAHDLRTPLAHVHTLLAHAAERAGTYDDAALASLVSRARNETDALLGRFRAML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
RIAEIGSLQRRGGFAEVDLEALVTDVGELFEPLAESREIRFQVRTEKVSAVHGDRALLFE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCHHHHHH
ALTNLLDNAIKYSPAGGSVRLELWQRLPGPCIEVIDDGPGIAPDEREAVLQHRYRSRRTV
HHHHHHHHHHEECCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCEE
HLAGSGLGLSIVSTVLNVHDFTLRIGGAAPGTRVTIECWPRTLV
EEECCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA