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The map label for this gene is ilvA [H]

Identifier: 238028623

GI number: 238028623

Start: 3510483

End: 3512006

Strand: Direct

Name: ilvA [H]

Synonym: bglu_1g30870

Alternate gene names: 238028623

Gene position: 3510483-3512006 (Clockwise)

Preceding gene: 238028604

Following gene: 238028624

Centisome position: 89.86

GC content: 70.6

Gene sequence:

>1524_bases
ATGGCTGCTCACGATTACCTGAAGAAGATCCTCACCGCGCGCGTCTACGACGTGGCGGTCGAAACCGCGCTTGAGGCGGC
CCGCAACCTGTCCGCGCGCGTGCGCAACCGCGTGCTGCTCAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCCTACAACCGCATGGCCCAGCTGGGCGCCGACGCGCTCGCGCGCGGCGTGATCACCGCCTCGGCCGGCAACCAC
GCCCAGGGCGTCGCGTTCTCGGCCGCGCGCCTGGGCGTGAAGGCGGTGATCGTGGTGCCGGTCACCACCCCGCAGGTCAA
GGTCGACGCGGTGCGCGCGCACGGCGGGCCGACCGTCGAGGTGATCCAGGCCGGCGAATCGTTCAGCGACGCCTATGCCC
ACGCGCTCGAGCTGCAGCGCCAGCGCGAGCTGACCTTCGTGCACCCGTTCGACGATCCCGAGGTGATCGCCGGCCAGGGC
ACCGTGGCGATGGAAGTGCTGCGCCAGCACCAGGGGCCGATCCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGC
GGCCGGCGTGGCCGCCTACGTGAAGGCGGTGCGCCCGGAGATCCGCGTGATCGGGGTGCAGACCGAGGACTCCTGCGCGA
TGGCGAAGTCGATCCGCGCCGGCGAGCGCGTGATGCTCGCCGAGGTGGGCCTGTTCTCGGACGGCACGGCCGTGAAGCAG
GTCGGCGAGGAAACGTTCCGGCTCTGCCGCGCGCTGCTCGACGAGGTGATCACGGTGGACACCGACGCGCTGTGCGCGGC
GATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTGGAGCCGGCCGGCGCGCTGGCCGTGGCGGGCGCCAAGCGCTACG
CGGCGCGCACCGGCATCGAGGGCGAGACGCTGGTGGCGATCACCTCGGGCGCCAACATGAACTTCGACCGGATGCGCTTC
GTGGCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAGGCGGTGTTCGCGGTGACGATCCCCGAGGAGCGCGGCAGCTTCCG
GCGCTTCTGCGAGCTGGTGGGCGAGCGCAGCGTGACGGAGTTCAACTACCGGATCGCCGACGAGCGCGCCGCGCACATTT
TCGTGGGCGTGCAGATCCGGCGCCGCGAGGAATCGGCCGAGATCGCGGCGAACTTCGGCGCGCACGGCTTCGAGGCGGCC
GACCTGACCGGCGACGAGCTGTCGAAGGATCACATTCGCTACATGGTGGGCGGGCGCTCGCCGCTCTCGCGCGACGAGCG
GCTGTTCCGCTTCGAGTTTCCGGAGCGCCCGGGCGCGCTGATGAAGTTTCTCTCGGCGATGGCGCCGAACTGGAACATCA
GCCTGTTCCACTACCGCAACCAGGGCGCGGACTACAGCTCGATCCTGGTCGGGCTGCAGGTGCCCGGCGCCGATCACGCC
ACGTTCGACCGGTTCCTGGCCGCGCTCGGCTATCCCTATCACGAAGAGACCGCGAACCCGGCCTACCGGCTGTTCCTGGC
GTAA

Upstream 100 bases:

>100_bases
GCCGGTCAACGGGCCAGCCGGCCCGCCGGGCCGGGGTTGGCGCTAAAATCCCGACTTTCCCCGCTTATCTGGCGCGCCGG
TCGATACCCGCGCGACCGTC

Downstream 100 bases:

>100_bases
TTGCAGAGAGACGCTCGATGACTCCCGAACATTCCCCGCTCGGCAAGGCCGCCGTCTACACGACCGACTACGACGCCGCG
CTGCTGTTTCCGATCCCGCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MAAHDYLKKILTARVYDVAVETALEAARNLSARVRNRVLLKREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNH
AQGVAFSAARLGVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQG
TVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQ
VGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEFNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAA
DLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGALMKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHA
TFDRFLAALGYPYHEETANPAYRLFLA

Sequences:

>Translated_507_residues
MAAHDYLKKILTARVYDVAVETALEAARNLSARVRNRVLLKREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNH
AQGVAFSAARLGVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQG
TVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQ
VGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEFNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAA
DLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGALMKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHA
TFDRFLAALGYPYHEETANPAYRLFLA
>Mature_506_residues
AAHDYLKKILTARVYDVAVETALEAARNLSARVRNRVLLKREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNHA
QGVAFSAARLGVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGT
VAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQV
GEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEFNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAAD
LTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGALMKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHAT
FDRFLAALGYPYHEETANPAYRLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=299, Percent_Identity=33.4448160535117, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI33469958, Length=317, Percent_Identity=28.7066246056782, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=55.3571428571429, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.3344051446945, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=318, Percent_Identity=29.874213836478, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=344, Percent_Identity=32.8488372093023, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17508781, Length=276, Percent_Identity=30.7971014492754, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=48.3558994197292, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=32.3529411764706, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319788, Length=271, Percent_Identity=25.4612546125461, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=28.9808917197452, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=27.0588235294118, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55206; Mature: 55075

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00889 CNMP_BINDING_2 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHDYLKKILTARVYDVAVETALEAARNLSARVRNRVLLKREDNQPVFSFKLRGAYNRM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECHHHHHH
AQLGADALARGVITASAGNHAQGVAFSAARLGVKAVIVVPVTTPQVKVDAVRAHGGPTVE
HHHCHHHHHHCEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVP
EEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQ
ECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
VGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCEEE
FNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRS
EEEEECCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCEECCCCCCCCCHHHHEEEECCCC
PLSRDERLFRFEFPERPGALMKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHA
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
TFDRFLAALGYPYHEETANPAYRLFLA
HHHHHHHHHCCCCHHCCCCCCEEEEEC
>Mature Secondary Structure 
AAHDYLKKILTARVYDVAVETALEAARNLSARVRNRVLLKREDNQPVFSFKLRGAYNRM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECHHHHHH
AQLGADALARGVITASAGNHAQGVAFSAARLGVKAVIVVPVTTPQVKVDAVRAHGGPTVE
HHHCHHHHHHCEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVP
EEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQ
ECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
VGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCEEE
FNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRS
EEEEECCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCEECCCCCCCCCHHHHEEEECCCC
PLSRDERLFRFEFPERPGALMKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHA
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
TFDRFLAALGYPYHEETANPAYRLFLA
HHHHHHHHHCCCCHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA