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The map label for this gene is ywrD [H]

Identifier: 238028573

GI number: 238028573

Start: 3450780

End: 3452420

Strand: Reverse

Name: ywrD [H]

Synonym: bglu_1g30370

Alternate gene names: 238028573

Gene position: 3452420-3450780 (Counterclockwise)

Preceding gene: 238028576

Following gene: 238028572

Centisome position: 88.38

GC content: 73.61

Gene sequence:

>1641_bases
ATGACCCGCTTCAACTGGCAGAACCCCTATCCCACCGTCCGGCAGCCCGTGTTCGCCCGCAATCTGGTCTCGACCTCGCA
CCCGCTCGCCGCGCAGGCCGGCCTGCGCATGCTCTGGCAGGGCGGCAACGCGGTGGACGCGGCGCTCGCCGCCGCCGCCG
CGCTCACCGTCGTCGAGCCGGTCTCGTGCGGACTCGGCGGCGACGCGTTCGCGCTGGTCTGGGACGGGGCGACGCTGTCG
GGCCTCAACGCCTCGGGCGTCGCGCCCGCGGCCTGGAACCCGGACTATTTCCGCCGCCGCCATGGCGAGGACGGCAACGG
CCACGCGCGGCAGCCCGAGCGCGGCTGGGATACGGTGACGGTGCCGGGCGTGGTCGCGGGCTGGGAGGCGCTGCACGCGC
GCTTCGGCTCGCTGCCGTTCGCCGACCTGCTCGCGCCGGCCATCGAACTGGCCGAGCGCGGTCATGCGGTGGCCTCGATC
GTGGCCCAGAAGTGGGCTGCCGCGGTGCCGGCGCTGCACGACCAGCCCGGCTTCGCGGCGGCGTTCCTGCCGCGCTCACG
CGCGCCGGAGGTGGGCGAGCGGGTGGTGATGCCAGGCCACGCCCGCACGCTGCGGCTGCTCGCGCGCGACGGCGCGCGCG
CCTTCTACGAGGGCGAGCCGGGCGCGGCGCTGGCCGCGTTCGCGCGCGAGACGGGCGGCGCGCTGACGGCCGAGGACCTG
CGGGCCTGGCGCCCCGAGTGGGTCGAGCCGATCGGCAAGTCGTTTCGCGGCCACACGGTGCACGAGATCCCGCCGAACGG
GCAGGGCATCGCGGCGCTGATCGCGCTCGGCATCGTCGAGCGCTTCGACCTGGCCGGGCTGCCGCTCGATTCGCCCGAGG
CGCAGCACGTGCAGATCGAGGCCATGAAGCTCGCGTTCGCCGACGTCTACCGCTACGTGGCCGATCCGCGCGCGATGGAG
GTGACGCCCGAGGCGATGCTCGACGATGCCTACCTGGCCGAGCGGGCGAAGCGCATCAACCTGTCGCGCGCGACGCATGT
CGAGCACGGCAGGCCGCGCGCGGGCGGCACCGTCTACCTGTCGGCTGCCGACGAGCGCGGCATGATGGTGAGCTTCATCC
AGTCGAACTACATGGGCTTCGGCTCGGGCCTGGTGGTGCCCGGCTACGGGATCGCGCTGCAGAACCGCGGCCACGGGTTC
TCGATGGACCCGGCCTCGCCGAACGTGGTGGCGGGCGGCAAGCGGCCGTTCCATACCATCATCCCGGCCTTCGTCACGCG
CGAGCGCGACGGCCGCCGCGAGGCGGTGATGAGCTTCGGCGTGATGGGCGGCGACATGCAGCCGCAAGGACACCTGCAGA
CCCTCGTGCGCATGCTCGGCTATGGGCAGCAGCCGCAGGCCGCCTGCGACGCGCCGCGCTGGAAGGTGAACCGCGATTTC
ACGCTCGACGTCGAGCACACCCTCGACCGCGGCGTGGTGGCCGCGCTCGAGGCGCGCGGCCACCGGCTGCAGTCGATCGC
CGATCCCTACATGGACTTCGGCTCGGGCCAGTTCATCTGGCGGCTCGACGCCGACGATCCCGAGCGCGGCTACGTGGCCG
CCAGCGACAGCCGTCGCGACGGGCTCGCGGCCGGCTTCTGA

Upstream 100 bases:

>100_bases
GCTGCAATGGCGCTTTGTCGCCTGCGGCAATCGCTTGCCTTGCCGCGCGCCCTTTCTGTTGTCGGCCGTGTTCGCACGTC
CATTCCACCGGAGCCGCAGC

Downstream 100 bases:

>100_bases
GCGCGGCCGCGTGTCGCGTCCCGGCCGCATCGGCGCGCGGCGCTGCCCCGCCGCGCGCGCGCGGGGCCTGCGGCATGCGC
GCCCGGTGCCGCCTGGTCCG

Product: Gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTRFNWQNPYPTVRQPVFARNLVSTSHPLAAQAGLRMLWQGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGATLS
GLNASGVAPAAWNPDYFRRRHGEDGNGHARQPERGWDTVTVPGVVAGWEALHARFGSLPFADLLAPAIELAERGHAVASI
VAQKWAAAVPALHDQPGFAAAFLPRSRAPEVGERVVMPGHARTLRLLARDGARAFYEGEPGAALAAFARETGGALTAEDL
RAWRPEWVEPIGKSFRGHTVHEIPPNGQGIAALIALGIVERFDLAGLPLDSPEAQHVQIEAMKLAFADVYRYVADPRAME
VTPEAMLDDAYLAERAKRINLSRATHVEHGRPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGYGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTRERDGRREAVMSFGVMGGDMQPQGHLQTLVRMLGYGQQPQAACDAPRWKVNRDF
TLDVEHTLDRGVVAALEARGHRLQSIADPYMDFGSGQFIWRLDADDPERGYVAASDSRRDGLAAGF

Sequences:

>Translated_546_residues
MTRFNWQNPYPTVRQPVFARNLVSTSHPLAAQAGLRMLWQGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGATLS
GLNASGVAPAAWNPDYFRRRHGEDGNGHARQPERGWDTVTVPGVVAGWEALHARFGSLPFADLLAPAIELAERGHAVASI
VAQKWAAAVPALHDQPGFAAAFLPRSRAPEVGERVVMPGHARTLRLLARDGARAFYEGEPGAALAAFARETGGALTAEDL
RAWRPEWVEPIGKSFRGHTVHEIPPNGQGIAALIALGIVERFDLAGLPLDSPEAQHVQIEAMKLAFADVYRYVADPRAME
VTPEAMLDDAYLAERAKRINLSRATHVEHGRPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGYGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTRERDGRREAVMSFGVMGGDMQPQGHLQTLVRMLGYGQQPQAACDAPRWKVNRDF
TLDVEHTLDRGVVAALEARGHRLQSIADPYMDFGSGQFIWRLDADDPERGYVAASDSRRDGLAAGF
>Mature_545_residues
TRFNWQNPYPTVRQPVFARNLVSTSHPLAAQAGLRMLWQGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGATLSG
LNASGVAPAAWNPDYFRRRHGEDGNGHARQPERGWDTVTVPGVVAGWEALHARFGSLPFADLLAPAIELAERGHAVASIV
AQKWAAAVPALHDQPGFAAAFLPRSRAPEVGERVVMPGHARTLRLLARDGARAFYEGEPGAALAAFARETGGALTAEDLR
AWRPEWVEPIGKSFRGHTVHEIPPNGQGIAALIALGIVERFDLAGLPLDSPEAQHVQIEAMKLAFADVYRYVADPRAMEV
TPEAMLDDAYLAERAKRINLSRATHVEHGRPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGYGIALQNRGHGFS
MDPASPNVVAGGKRPFHTIIPAFVTRERDGRREAVMSFGVMGGDMQPQGHLQTLVRMLGYGQQPQAACDAPRWKVNRDFT
LDVEHTLDRGVVAALEARGHRLQSIADPYMDFGSGQFIWRLDADDPERGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=557, Percent_Identity=29.6229802513465, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915090, Length=557, Percent_Identity=29.6229802513465, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915096, Length=557, Percent_Identity=29.6229802513465, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI73915094, Length=557, Percent_Identity=29.6229802513465, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=28.4172661870504, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI113429326, Length=561, Percent_Identity=28.1639928698752, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=29.4003868471954, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI153266885, Length=555, Percent_Identity=25.5855855855856, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI153266901, Length=556, Percent_Identity=25.7194244604317, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI153266907, Length=553, Percent_Identity=24.4122965641953, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1789856, Length=561, Percent_Identity=29.4117647058824, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI72000294, Length=529, Percent_Identity=24.952741020794, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI212646519, Length=529, Percent_Identity=24.952741020794, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=524, Percent_Identity=25.381679389313, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193208245, Length=510, Percent_Identity=24.9019607843137, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=510, Percent_Identity=24.9019607843137, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=532, Percent_Identity=23.1203007518797, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24642670, Length=563, Percent_Identity=25.5772646536412, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642666, Length=563, Percent_Identity=25.5772646536412, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45551474, Length=563, Percent_Identity=25.3996447602131, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161077878, Length=563, Percent_Identity=25.3996447602131, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161077880, Length=563, Percent_Identity=25.3996447602131, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18859893, Length=520, Percent_Identity=26.1538461538462, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859741, Length=522, Percent_Identity=26.6283524904215, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077496, Length=512, Percent_Identity=25.5859375, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58778; Mature: 58647

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFNWQNPYPTVRQPVFARNLVSTSHPLAAQAGLRMLWQGGNAVDAALAAAAALTVVEP
CCCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
VSCGLGGDAFALVWDGATLSGLNASGVAPAAWNPDYFRRRHGEDGNGHARQPERGWDTVT
HHCCCCCCEEEEEECCCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEE
VPGVVAGWEALHARFGSLPFADLLAPAIELAERGHAVASIVAQKWAAAVPALHDQPGFAA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AFLPRSRAPEVGERVVMPGHARTLRLLARDGARAFYEGEPGAALAAFARETGGALTAEDL
EECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCHHHH
RAWRPEWVEPIGKSFRGHTVHEIPPNGQGIAALIALGIVERFDLAGLPLDSPEAQHVQIE
HHCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHH
AMKLAFADVYRYVADPRAMEVTPEAMLDDAYLAERAKRINLSRATHVEHGRPRAGGTVYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGYGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTRERDGRREAVMSFGVMGGDMQPQGHLQTLVRMLGYGQQPQAACDAPRWKVNRDF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEECCCCE
TLDVEHTLDRGVVAALEARGHRLQSIADPYMDFGSGQFIWRLDADDPERGYVAASDSRRD
EEEHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC
>Mature Secondary Structure 
TRFNWQNPYPTVRQPVFARNLVSTSHPLAAQAGLRMLWQGGNAVDAALAAAAALTVVEP
CCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
VSCGLGGDAFALVWDGATLSGLNASGVAPAAWNPDYFRRRHGEDGNGHARQPERGWDTVT
HHCCCCCCEEEEEECCCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEE
VPGVVAGWEALHARFGSLPFADLLAPAIELAERGHAVASIVAQKWAAAVPALHDQPGFAA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AFLPRSRAPEVGERVVMPGHARTLRLLARDGARAFYEGEPGAALAAFARETGGALTAEDL
EECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCHHHH
RAWRPEWVEPIGKSFRGHTVHEIPPNGQGIAALIALGIVERFDLAGLPLDSPEAQHVQIE
HHCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHH
AMKLAFADVYRYVADPRAMEVTPEAMLDDAYLAERAKRINLSRATHVEHGRPRAGGTVYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGYGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTRERDGRREAVMSFGVMGGDMQPQGHLQTLVRMLGYGQQPQAACDAPRWKVNRDF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEECCCCE
TLDVEHTLDRGVVAALEARGHRLQSIADPYMDFGSGQFIWRLDADDPERGYVAASDSRRD
EEEHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]