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The map label for this gene is arpR [H]

Identifier: 238028499

GI number: 238028499

Start: 3356279

End: 3356923

Strand: Direct

Name: arpR [H]

Synonym: bglu_1g29630

Alternate gene names: 238028499

Gene position: 3356279-3356923 (Clockwise)

Preceding gene: 238028495

Following gene: 238028505

Centisome position: 85.92

GC content: 65.58

Gene sequence:

>645_bases
ATGGCCAGACGCACCAAAGAGGAAGCGCTCGAAACCCGCAACCGCATCCTCGATGCCGCCGAACACGTGTTCTTCGAGAA
AGGCGTGTCGCATACGACGCTCGCCGACATCGCCCAGCACGCCGGCGTCACGCGCGGCGCCATCTACTGGCACTTCGCGA
ACAAGAGCGAGCTGTTCGATGCGATGTCCGACCGTGTGTTCTTGCCGATCGACGAGCTGAAGGCAACCTCGGACAAACCG
CGTGCCGATCCGCTCGGGCGGATCCGCAAGATCCTGGTCTGGTGTCTGCTCGGCGTGGCGCGCGATTCGCAGTTGCGACG
CGTGTTCAGCATCCTGTTCATGAAGTGCGAGTACGTGGCCGACATGGAGCCGCTGCTGCAGCGCAACCGCGCCGGCATGT
CCAAGGCGCTGCACAATATCGAGGGCGATTTGAAACAGGCGGTGGCCAGCGGCGAGCTGCCGGCCGACCTCGACACCTGG
CGCGCCACGCTGATGCTGCACACGCTGGTGAGCGGTTTCGTGCGCGACATGCTGATGCTGCCCGACGAGATCGACGCGGA
GCAGCACGCGGAGCGGCTCGTCGATGCCGTGTTCGACATGCTGAGCCTGAGCCCGGCGATGCGGCGCGCGCCGCCGCCGG
ACTGA

Upstream 100 bases:

>100_bases
AATCGGGCCCGTCGCACCGATTCTTGCACGATTCGAATCAATCGACGGCCTTTCCCCTCATCACTACCGACGTCCAAGCA
CGTCGCCACCGACACTCGCA

Downstream 100 bases:

>100_bases
GCCATCCGCGGCCGGCCCGGCGCCGATTATCGGCCGGCCCGGCGCGCGGGAGCCATCCGCGTTCTCGTCGCGCCCCCGCG
CCGCGCCTCGGCGCTCCCCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MARRTKEEALETRNRILDAAEHVFFEKGVSHTTLADIAQHAGVTRGAIYWHFANKSELFDAMSDRVFLPIDELKATSDKP
RADPLGRIRKILVWCLLGVARDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSKALHNIEGDLKQAVASGELPADLDTW
RATLMLHTLVSGFVRDMLMLPDEIDAEQHAERLVDAVFDMLSLSPAMRRAPPPD

Sequences:

>Translated_214_residues
MARRTKEEALETRNRILDAAEHVFFEKGVSHTTLADIAQHAGVTRGAIYWHFANKSELFDAMSDRVFLPIDELKATSDKP
RADPLGRIRKILVWCLLGVARDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSKALHNIEGDLKQAVASGELPADLDTW
RATLMLHTLVSGFVRDMLMLPDEIDAEQHAERLVDAVFDMLSLSPAMRRAPPPD
>Mature_213_residues
ARRTKEEALETRNRILDAAEHVFFEKGVSHTTLADIAQHAGVTRGAIYWHFANKSELFDAMSDRVFLPIDELKATSDKPR
ADPLGRIRKILVWCLLGVARDSQLRRVFSILFMKCEYVADMEPLLQRNRAGMSKALHNIEGDLKQAVASGELPADLDTWR
ATLMLHTLVSGFVRDMLMLPDEIDAEQHAERLVDAVFDMLSLSPAMRRAPPPD

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=209, Percent_Identity=39.2344497607655, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789664, Length=208, Percent_Identity=34.1346153846154, Blast_Score=98, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24182; Mature: 24051

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRTKEEALETRNRILDAAEHVFFEKGVSHTTLADIAQHAGVTRGAIYWHFANKSELFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMSDRVFLPIDELKATSDKPRADPLGRIRKILVWCLLGVARDSQLRRVFSILFMKCEYVA
HHHCCEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
DMEPLLQRNRAGMSKALHNIEGDLKQAVASGELPADLDTWRATLMLHTLVSGFVRDMLML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PDEIDAEQHAERLVDAVFDMLSLSPAMRRAPPPD
CCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
>Mature Secondary Structure 
ARRTKEEALETRNRILDAAEHVFFEKGVSHTTLADIAQHAGVTRGAIYWHFANKSELFD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMSDRVFLPIDELKATSDKPRADPLGRIRKILVWCLLGVARDSQLRRVFSILFMKCEYVA
HHHCCEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
DMEPLLQRNRAGMSKALHNIEGDLKQAVASGELPADLDTWRATLMLHTLVSGFVRDMLML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PDEIDAEQHAERLVDAVFDMLSLSPAMRRAPPPD
CCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]