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The map label for this gene is hutC [H]

Identifier: 238027405

GI number: 238027405

Start: 1979798

End: 1980520

Strand: Reverse

Name: hutC [H]

Synonym: bglu_1g18010

Alternate gene names: 238027405

Gene position: 1980520-1979798 (Counterclockwise)

Preceding gene: 238027406

Following gene: 238027403

Centisome position: 50.7

GC content: 69.16

Gene sequence:

>723_bases
GTGGACGATGCGCAGCAGCCGGCGGGGGGGCGCAAGCCGGCGCCCGCCTATGAGCAGATCAAGCGCTACGTGATCGGCCA
CATCGCCAGCGGCACCTGGAAGCCCGGCGAGATGATCCCGTCCGAAACCGAGCTCGTGAAGGAATTCGGCGTGGCGCGCA
TGACCGTCTCGCGCGCGCTGCGCGAACTGACCGCCGAACGCGTGCTCACGCGCGTGCAGGGCTCGGGCACCTTCGTCGCG
CCGCGCGACGTCGAATCCACCGTGCTCGACGTGCGCAACATCGCCGACGAGATCGTGGCGCGCGGGCACCATCACAGCGC
GAAGGTGCTGCTGCTGGAGGCGAGCCTCGATCCGCAGGCGTGCGCCGCGCTCGATCTGGCGGCCGGCCCGGTGTTCCATT
CGCTGATCGTCCATTACGAGGAAGGCGAGCCGATCCAGTACGAGGATCGCTACGTGAACCCACGGGTGTTTCCGCAGTAC
CTGGAGCAGGACTTCACGGCCGAGACGCCGAACCGCTACATGGTGCGGCTCGCGCCAATCCAGCGCGCCGACTTCCGCAT
CTATGCGCGCAAGCCCGAGGCGCCGATCCGCCGCCATCTGTCCATGGAGATCGGCGAGCCGTGCCTGCTGATGTGGCGGC
GCACCTGGGTCGGCGAGGCGGTGGCCACCGCCGTGCAGCTCTGGCACCCGGCCTCGCGCTTTCACCTGGCCGGCAGCATG
TGA

Upstream 100 bases:

>100_bases
TGCCCGCGGCGATCGGCGGCTGACCGGCGGCCTCCTGCGGTCGCGGCCGGCCGATCGCCCCTCACCGACGAAGTCGAGAA
CAACGATGATCAGGAATCCA

Downstream 100 bases:

>100_bases
GCGCCGGGCGGGGCGCGCGAACCGTTGCCAAGCAAAACGCCCCCGCATCGAGACGATGCGGGGGCGTGGAGGGCGCAGGG
CGCGGCGCCGGAAGGCAAGC

Product: histidine utilization repressor GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MDDAQQPAGGRKPAPAYEQIKRYVIGHIASGTWKPGEMIPSETELVKEFGVARMTVSRALRELTAERVLTRVQGSGTFVA
PRDVESTVLDVRNIADEIVARGHHHSAKVLLLEASLDPQACAALDLAAGPVFHSLIVHYEEGEPIQYEDRYVNPRVFPQY
LEQDFTAETPNRYMVRLAPIQRADFRIYARKPEAPIRRHLSMEIGEPCLLMWRRTWVGEAVATAVQLWHPASRFHLAGSM

Sequences:

>Translated_240_residues
MDDAQQPAGGRKPAPAYEQIKRYVIGHIASGTWKPGEMIPSETELVKEFGVARMTVSRALRELTAERVLTRVQGSGTFVA
PRDVESTVLDVRNIADEIVARGHHHSAKVLLLEASLDPQACAALDLAAGPVFHSLIVHYEEGEPIQYEDRYVNPRVFPQY
LEQDFTAETPNRYMVRLAPIQRADFRIYARKPEAPIRRHLSMEIGEPCLLMWRRTWVGEAVATAVQLWHPASRFHLAGSM
>Mature_240_residues
MDDAQQPAGGRKPAPAYEQIKRYVIGHIASGTWKPGEMIPSETELVKEFGVARMTVSRALRELTAERVLTRVQGSGTFVA
PRDVESTVLDVRNIADEIVARGHHHSAKVLLLEASLDPQACAALDLAAGPVFHSLIVHYEEGEPIQYEDRYVNPRVFPQY
LEQDFTAETPNRYMVRLAPIQRADFRIYARKPEAPIRRHLSMEIGEPCLLMWRRTWVGEAVATAVQLWHPASRFHLAGSM

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=197, Percent_Identity=29.4416243654822, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=28.3582089552239, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790118, Length=143, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27020; Mature: 27020

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDAQQPAGGRKPAPAYEQIKRYVIGHIASGTWKPGEMIPSETELVKEFGVARMTVSRAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RELTAERVLTRVQGSGTFVAPRDVESTVLDVRNIADEIVARGHHHSAKVLLLEASLDPQA
HHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
CAALDLAAGPVFHSLIVHYEEGEPIQYEDRYVNPRVFPQYLEQDFTAETPNRYMVRLAPI
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECC
QRADFRIYARKPEAPIRRHLSMEIGEPCLLMWRRTWVGEAVATAVQLWHPASRFHLAGSM
CCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC
>Mature Secondary Structure
MDDAQQPAGGRKPAPAYEQIKRYVIGHIASGTWKPGEMIPSETELVKEFGVARMTVSRAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RELTAERVLTRVQGSGTFVAPRDVESTVLDVRNIADEIVARGHHHSAKVLLLEASLDPQA
HHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
CAALDLAAGPVFHSLIVHYEEGEPIQYEDRYVNPRVFPQYLEQDFTAETPNRYMVRLAPI
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECC
QRADFRIYARKPEAPIRRHLSMEIGEPCLLMWRRTWVGEAVATAVQLWHPASRFHLAGSM
CCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]