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The map label for this gene is thiD [H]

Identifier: 238026381

GI number: 238026381

Start: 775079

End: 775942

Strand: Reverse

Name: thiD [H]

Synonym: bglu_1g07160

Alternate gene names: 238026381

Gene position: 775942-775079 (Counterclockwise)

Preceding gene: 238026390

Following gene: 238026374

Centisome position: 19.86

GC content: 71.41

Gene sequence:

>864_bases
ATGTCCAGCAACGCCCCCCCGATCGTCCTCACATTCGGCCTGTCCGATCCCACCGGCGGCTCCGGCCTGCAGGCGGACCT
GCTGACACTGGCGAGCATGGGTTGCCACGGCGCGTCGGTGCTGACGGGTTATACGATCCGCGATTCGGCGTCCTGCGACG
AGGTCACCGGCCTCGACCCCGATGCCGTGGTCGCGCAGGCCCGCATGCTGCTCGAGGACATGCCCGTGGCCGCCTTCAAG
ATCGGCGCGACCGCGCGTGCCGAGGTGGTCAGTGCGATCGCCGAGGTGGTGGCCGACTACGACGGCGTGCCGCTCGTGCT
GGCGCCAGACTTCACGCTCGACGACGAGCACGTGCTGGCCGCCGACGACCTGCGTGAATCGATCGCGGACCTGCTCGCGC
CGCAGACCACGCTGCTGGTGGCCGATCACGCCACGCTGATCGCGCTCGCCCAGCCCGACGGCGACGCGGAGGCGCCGAAT
CTCGACGCGGCGATCGCGCATCTGCTCTCGCAGGGCTGCGAATACATCCTCGCGACCGAAACCGGCTCGCACCGGCTCGT
CAACACGCTGTACGGCGAAGAGGGGCAGATCCGCCAGGACTTGTGGGAGCGCACGCCGCACCGGCTGATGGGCGTGACCG
ACACCCTCGGCACCGCGATCGCGGCGCTGCTGGCCAACGGCCAGGAGCCGCCCGAGGCCGTGCGCGAAGCGCAGGAATAC
CTCTATCAGGCCGCCCGCGACGCGTTCCGGCCCGGCATGGGCGCCTGGGTGCCCGACCGCTTCTTCTGGGCGCGCAGCAA
CGACGATGCGCCGGCCGCGCCGGCCGCACCCGCCACCCCGCCGTTCGGCGCATCACGCCACTGA

Upstream 100 bases:

>100_bases
TAAAAAAACCGTTTCACGCGCAGCTTTCCCACGCATAATGACCGGCAAGGCACGCCCGCGTGGTGCGCCGCCCGCTCGTT
ATCTCTTTCCCCGATTTTTC

Downstream 100 bases:

>100_bases
CGGGCCGCCGGCCGGCCGCGTTTCCGGCGTCGCGCGCGGCGCCGAGCAGCCGGGCCGCAAACGACAAAAAACCCGCAATC
GCTTGCGGGTTTTTTTTGGC

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSSNAPPIVLTFGLSDPTGGSGLQADLLTLASMGCHGASVLTGYTIRDSASCDEVTGLDPDAVVAQARMLLEDMPVAAFK
IGATARAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAAIAHLLSQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGVTDTLGTAIAALLANGQEPPEAVREAQEY
LYQAARDAFRPGMGAWVPDRFFWARSNDDAPAAPAAPATPPFGASRH

Sequences:

>Translated_287_residues
MSSNAPPIVLTFGLSDPTGGSGLQADLLTLASMGCHGASVLTGYTIRDSASCDEVTGLDPDAVVAQARMLLEDMPVAAFK
IGATARAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAAIAHLLSQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGVTDTLGTAIAALLANGQEPPEAVREAQEY
LYQAARDAFRPGMGAWVPDRFFWARSNDDAPAAPAAPATPPFGASRH
>Mature_286_residues
SSNAPPIVLTFGLSDPTGGSGLQADLLTLASMGCHGASVLTGYTIRDSASCDEVTGLDPDAVVAQARMLLEDMPVAAFKI
GATARAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNL
DAAIAHLLSQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGVTDTLGTAIAALLANGQEPPEAVREAQEYL
YQAARDAFRPGMGAWVPDRFFWARSNDDAPAAPAAPATPPFGASRH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=240, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30166; Mature: 30035

Theoretical pI: Translated: 4.05; Mature: 4.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNAPPIVLTFGLSDPTGGSGLQADLLTLASMGCHGASVLTGYTIRDSASCDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCEEECCCCCCCCCCCCCH
DAVVAQARMLLEDMPVAAFKIGATARAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAIAHLLSQGCEYILATE
HHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEC
TGSHRLVNTLYGEEGQIRQDLWERTPHRLMGVTDTLGTAIAALLANGQEPPEAVREAQEY
CCCCHHHHHHCCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAARDAFRPGMGAWVPDRFFWARSNDDAPAAPAAPATPPFGASRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNAPPIVLTFGLSDPTGGSGLQADLLTLASMGCHGASVLTGYTIRDSASCDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCEEECCCCCCCCCCCCCH
DAVVAQARMLLEDMPVAAFKIGATARAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAIAHLLSQGCEYILATE
HHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEC
TGSHRLVNTLYGEEGQIRQDLWERTPHRLMGVTDTLGTAIAALLANGQEPPEAVREAQEY
CCCCHHHHHHCCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAARDAFRPGMGAWVPDRFFWARSNDDAPAAPAAPATPPFGASRH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]