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The map label for this gene is cobB2 [H]

Identifier: 238024187

GI number: 238024187

Start: 929898

End: 930809

Strand: Direct

Name: cobB2 [H]

Synonym: bglu_2g07660

Alternate gene names: 238024187

Gene position: 929898-930809 (Clockwise)

Preceding gene: 238024186

Following gene: 238024188

Centisome position: 32.89

GC content: 73.36

Gene sequence:

>912_bases
ATGAACGATCCAGATCCCCTGTCCGCCGCGGCCCTCATCGATTCGACGGCGGACCCCGCGGCGCTCGATGCGCTGCAGGC
CTTCGTCGAACGCCATCCGCGCCTGTTCGTCCTGACGGGCGCCGGCATCAGCACCGATTCCGGCATTCCCGGCTATCGCG
ACCGCAATGGCCAGTGGATGCGCTCCCAGCCGATCCAGTATCAGGAATTCGTCGGCTCCGAGCAGGCGCGGCGCCGTTAT
TGGGCACGCAGCATGCTCGGCTGGCCGGTGGTGGGCCGCGCCCGGCCGAACGCCGCGCACCTCGCGCTGGCCCGGATCGG
CGCGGCCGGGCGCATCGGCCGGCTGGTCACGCAGAACGTGGACGGCCTGCATCAGCGCGCCGGCAGCGCCGACGTGATCG
AGCTGCACGGCGGCATCGACGGCGTGACCTGCCTGGCCTGCGGCGCCCACCATTCGCGCGCCGCGATCCAGCTCACGCTC
GAGGCCGACAATCCCGCGCTGCTCGCCGTGGAGGCCGCGCCGCTGGCGGACGGCGACGCGCAGCTGGAGGAGCGGGCGGT
GCTCGATGCGTTCCGCGTGCCGGACTGCCCGATCTGCGGCGGCATGCTGAAGCCGGCCGTGGTGTTCTTCGGCGAGAACG
TGCCGCGCGAGCGCGTTGCCGCGGCGGCGCTCGCGCTCGACGAGGCCGACGCGATGCTGGTGGTCGGCTCGTCGCTGATG
GTGTATTCGGGTTACCGCTTCTGCGTCTGGGCAGGGCAGCGCGGCAAGCCCGTGGCCGCCCTCAACCTCGGCCGCACGCG
TGCCGATCCGCTGCTCGCGCTGAAGGTCGAGGTGCCGTGCGGGCCCGCGCTCGACGCGCTGGCCGGGCGGCTCGGGCTCG
GCGGCGGTCCGGCCGGCCACTTGCCGGCATGA

Upstream 100 bases:

>100_bases
GCCGCGCGGCGGGCGGGTTCGGTATGATGGCCCCACAATGGTCATCAGGCAGGCATCGGCCGCGCTCCCGCGCCGCGCCT
GCCGGACTTCCCCACCAGCC

Downstream 100 bases:

>100_bases
ATGCACCGGCTGAATTCGACGGCCGAGGGCGCGCGCGGCAGGCTCGGCAACAGCCAGGGCGAGCGGGATGCGCGACGCTG
CCCCGGCCGGCCCGGTGCCG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNDPDPLSAAALIDSTADPAALDALQAFVERHPRLFVLTGAGISTDSGIPGYRDRNGQWMRSQPIQYQEFVGSEQARRRY
WARSMLGWPVVGRARPNAAHLALARIGAAGRIGRLVTQNVDGLHQRAGSADVIELHGGIDGVTCLACGAHHSRAAIQLTL
EADNPALLAVEAAPLADGDAQLEERAVLDAFRVPDCPICGGMLKPAVVFFGENVPRERVAAAALALDEADAMLVVGSSLM
VYSGYRFCVWAGQRGKPVAALNLGRTRADPLLALKVEVPCGPALDALAGRLGLGGGPAGHLPA

Sequences:

>Translated_303_residues
MNDPDPLSAAALIDSTADPAALDALQAFVERHPRLFVLTGAGISTDSGIPGYRDRNGQWMRSQPIQYQEFVGSEQARRRY
WARSMLGWPVVGRARPNAAHLALARIGAAGRIGRLVTQNVDGLHQRAGSADVIELHGGIDGVTCLACGAHHSRAAIQLTL
EADNPALLAVEAAPLADGDAQLEERAVLDAFRVPDCPICGGMLKPAVVFFGENVPRERVAAAALALDEADAMLVVGSSLM
VYSGYRFCVWAGQRGKPVAALNLGRTRADPLLALKVEVPCGPALDALAGRLGLGGGPAGHLPA
>Mature_303_residues
MNDPDPLSAAALIDSTADPAALDALQAFVERHPRLFVLTGAGISTDSGIPGYRDRNGQWMRSQPIQYQEFVGSEQARRRY
WARSMLGWPVVGRARPNAAHLALARIGAAGRIGRLVTQNVDGLHQRAGSADVIELHGGIDGVTCLACGAHHSRAAIQLTL
EADNPALLAVEAAPLADGDAQLEERAVLDAFRVPDCPICGGMLKPAVVFFGENVPRERVAAAALALDEADAMLVVGSSLM
VYSGYRFCVWAGQRGKPVAALNLGRTRADPLLALKVEVPCGPALDALAGRLGLGGGPAGHLPA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=271, Percent_Identity=48.3394833948339, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI6912664, Length=278, Percent_Identity=30.9352517985612, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI300795542, Length=284, Percent_Identity=28.169014084507, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI13787215, Length=257, Percent_Identity=30.7392996108949, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI6912660, Length=218, Percent_Identity=30.2752293577982, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI63054862, Length=214, Percent_Identity=29.9065420560748, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI300797577, Length=257, Percent_Identity=27.2373540856031, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI308199517, Length=283, Percent_Identity=31.8021201413428, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71990482, Length=260, Percent_Identity=41.9230769230769, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71990487, Length=262, Percent_Identity=41.6030534351145, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17567771, Length=275, Percent_Identity=36, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17541892, Length=232, Percent_Identity=30.6034482758621, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=273, Percent_Identity=22.3443223443223, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571445, Length=269, Percent_Identity=43.8661710037175, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28571443, Length=219, Percent_Identity=43.37899543379, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28571441, Length=219, Percent_Identity=43.37899543379, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137536, Length=253, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648389, Length=218, Percent_Identity=25.2293577981651, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31784; Mature: 31784

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPDPLSAAALIDSTADPAALDALQAFVERHPRLFVLTGAGISTDSGIPGYRDRNGQWM
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEE
RSQPIQYQEFVGSEQARRRYWARSMLGWPVVGRARPNAAHLALARIGAAGRIGRLVTQNV
CCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCH
DGLHQRAGSADVIELHGGIDGVTCLACGAHHSRAAIQLTLEADNPALLAVEAAPLADGDA
HHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCH
QLEERAVLDAFRVPDCPICGGMLKPAVVFFGENVPRERVAAAALALDEADAMLVVGSSLM
HHHHHHHHHHHCCCCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCEEE
VYSGYRFCVWAGQRGKPVAALNLGRTRADPLLALKVEVPCGPALDALAGRLGLGGGPAGH
EECCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCC
LPA
CCC
>Mature Secondary Structure
MNDPDPLSAAALIDSTADPAALDALQAFVERHPRLFVLTGAGISTDSGIPGYRDRNGQWM
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEE
RSQPIQYQEFVGSEQARRRYWARSMLGWPVVGRARPNAAHLALARIGAAGRIGRLVTQNV
CCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCH
DGLHQRAGSADVIELHGGIDGVTCLACGAHHSRAAIQLTLEADNPALLAVEAAPLADGDA
HHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCH
QLEERAVLDAFRVPDCPICGGMLKPAVVFFGENVPRERVAAAALALDEADAMLVVGSSLM
HHHHHHHHHHHCCCCCCCCCCHHHCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCEEE
VYSGYRFCVWAGQRGKPVAALNLGRTRADPLLALKVEVPCGPALDALAGRLGLGGGPAGH
EECCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCC
LPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]