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The map label for this gene is nrdB [H]

Identifier: 238023979

GI number: 238023979

Start: 636101

End: 637114

Strand: Reverse

Name: nrdB [H]

Synonym: bglu_2g05290

Alternate gene names: 238023979

Gene position: 637114-636101 (Counterclockwise)

Preceding gene: 238023980

Following gene: 238023978

Centisome position: 22.53

GC content: 64.1

Gene sequence:

>1014_bases
ATGACATCGCTAAAACCTGCCCGTGTTGAAGACAAGCGCGTCGTCAACGGCGCCGGCGACATCAACCAGCTCGCGCCGTT
CCGCTACGCCTGGGCATGGGAGTGCTTTCTCTCGGCCAACAAGAACCACTGGACGCCGCTCGAAATCTCGATGAGCGACG
ACGTGCACGACTTCCACCACCGCCTGAGCCCGGCGGAAAAGCATGTGTTCGAGAACGTGCTCGCCTACCTGACCACCTCC
GACATCCTCGCCATGCGCAACATCGGGCTGGCCGTGATGGAGAAGATGACGGCGCCGGAGCTGCAGATCTACCAGGCCCG
GCAGGTCTATGAGGAAGCGCTGCACACCTGGACCTACCAGCACTGCATCGAAAGCCTCGGCCTCGACCAGCAGGAAATCT
ACAACCGCTACCGCGTCGTGCCGCAGATCCACGCGAAGATCGCGCTGTCGAACCGGCGCCTGAACCGGATGCTGGAGCCG
GGCCTGGACCTGCACGACCGCGACACGCTGCACGAGTTCGCGCTCGCCTACCTGTTCTTCGCGGCCGTGTTCGAGGGCAC
CTGGTTCTACAACGGCTTCTCGCCCGTGTTCGCGCTGCAGCGCCGCGGCCTGATGAAGGCCACCGCCCAGCAGTTCCAGT
ACATCATGCGCGACGAGGTGCTGCATTGCGGCTTCGGCATTCGCGTGATCCGGCAATTGCTCGAGGAGGAACACCTGCGT
CTCGACCCGCACGCCGTGCAGCAGATCTGGGAGGAAGCCGAGGCGGCCGAGCGTGCCTATGCGCAGTACATCCTGCGCGA
TCCGATCCTCGGCTATTCGGCGGAACTGCACTGCGAGCAGTTCCGCTTCATCGCGAATCGCCGCGCCACCCAGTTGTCGA
TGCCGGCGCCGTTCCCCGGCGCGACCAATGCACTGCCCTGGCTCGACGAGCAGGCCAACCTGCGCAAGGAGAAAAACTTC
TTCGAAACGCGCGTGACCGACTACCAATCGGGCGGCGCGCTGGACTGGCGCTGA

Upstream 100 bases:

>100_bases
CCTGGAATCCCGGCCTGCCGCCAGGCAGCCCGCGGCCCGCGCGGCGCAGCCGATGGCTACGCCGATGCGCGGTGCCGCTT
TCATTTTGGTATGCAAATCA

Downstream 100 bases:

>100_bases
CGGGGGCGCGCTCCCCGCACGGCCGCATGCCGGCTTCGGCGCCGGCCGCGCTCCAGGCGGGCATCGCTCACGCTGCGATA
CCCGCCTACCTATAATCAGG

Product: Ribonucleotide reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTSLKPARVEDKRVVNGAGDINQLAPFRYAWAWECFLSANKNHWTPLEISMSDDVHDFHHRLSPAEKHVFENVLAYLTTS
DILAMRNIGLAVMEKMTAPELQIYQARQVYEEALHTWTYQHCIESLGLDQQEIYNRYRVVPQIHAKIALSNRRLNRMLEP
GLDLHDRDTLHEFALAYLFFAAVFEGTWFYNGFSPVFALQRRGLMKATAQQFQYIMRDEVLHCGFGIRVIRQLLEEEHLR
LDPHAVQQIWEEAEAAERAYAQYILRDPILGYSAELHCEQFRFIANRRATQLSMPAPFPGATNALPWLDEQANLRKEKNF
FETRVTDYQSGGALDWR

Sequences:

>Translated_337_residues
MTSLKPARVEDKRVVNGAGDINQLAPFRYAWAWECFLSANKNHWTPLEISMSDDVHDFHHRLSPAEKHVFENVLAYLTTS
DILAMRNIGLAVMEKMTAPELQIYQARQVYEEALHTWTYQHCIESLGLDQQEIYNRYRVVPQIHAKIALSNRRLNRMLEP
GLDLHDRDTLHEFALAYLFFAAVFEGTWFYNGFSPVFALQRRGLMKATAQQFQYIMRDEVLHCGFGIRVIRQLLEEEHLR
LDPHAVQQIWEEAEAAERAYAQYILRDPILGYSAELHCEQFRFIANRRATQLSMPAPFPGATNALPWLDEQANLRKEKNF
FETRVTDYQSGGALDWR
>Mature_336_residues
TSLKPARVEDKRVVNGAGDINQLAPFRYAWAWECFLSANKNHWTPLEISMSDDVHDFHHRLSPAEKHVFENVLAYLTTSD
ILAMRNIGLAVMEKMTAPELQIYQARQVYEEALHTWTYQHCIESLGLDQQEIYNRYRVVPQIHAKIALSNRRLNRMLEPG
LDLHDRDTLHEFALAYLFFAAVFEGTWFYNGFSPVFALQRRGLMKATAQQFQYIMRDEVLHCGFGIRVIRQLLEEEHLRL
DPHAVQQIWEEAEAAERAYAQYILRDPILGYSAELHCEQFRFIANRRATQLSMPAPFPGATNALPWLDEQANLRKEKNFF
ETRVTDYQSGGALDWR

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=307, Percent_Identity=25.7328990228013, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI289177074, Length=307, Percent_Identity=25.4071661237785, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4557845, Length=312, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI260064013, Length=313, Percent_Identity=24.9201277955272, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI289177076, Length=285, Percent_Identity=25.2631578947368, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788567, Length=291, Percent_Identity=25.085910652921, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17551968, Length=312, Percent_Identity=23.7179487179487, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322434, Length=314, Percent_Identity=28.0254777070064, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI18079279, Length=317, Percent_Identity=25.8675078864353, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 39305; Mature: 39174

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TSLKPARVEDKRVVNGAGDINQLAPFRYAWAWECFLSANKNHWTPLEISMSDDVHDFHH
CCCCCCCCCCCHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHH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CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]