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The map label for this gene is ivd [H]

Identifier: 23500935

GI number: 23500935

Start: 22864

End: 24012

Strand: Reverse

Name: ivd [H]

Synonym: BR0020

Alternate gene names: 23500935

Gene position: 24012-22864 (Counterclockwise)

Preceding gene: 23500936

Following gene: 23500934

Centisome position: 1.14

GC content: 59.09

Gene sequence:

>1149_bases
ATGAACTTCGGTCTTGGCGAGGAGATCGAAGCCCTTCGTGACACTGTGCGCCGTTTCGCCGAAAGCCGCATTGCGCCGCT
TGCCGCTGAAACCGACCGCAATAATCAATTTCCCATGCATCTTTGGCGTGAATTTGGTGAGCTTGGCGTACTCGGCATTA
CGGCGCCGGAAGACTATGGTGGCGCAGGCATGGGCTATCTCGCCCATTGCATCGCCATGGAGGAGATCAGCCGTGCTTCC
GCCTCCATCGGCCTTAGCTACGGCGCCCATTCCAATCTCTGCGTCAACCAGATCACCCGCAACGGTTCGCCCGAACAGCG
CGCGAAATATCTGCCGAAACTCATTTCCGGTGAGCATGTCGGCGCGCTGGCCATGTCTGAGCCGGGCGCGGGGTCCGATG
TTGTTTCCATGAAGCTTGCCGCCGAAAAGCGCGGGGACCGTTACGTCCTCAACGGCAACAAGATGTGGATCACCAATGGC
CCGGATGCCGATGTGCTGGTGGTCTATGCCAAGACAGACCTGTCGGCTGGCCCGCGCGGGATCAGCGCCTTTATCATTGA
AAAAGGGTTCAAGGGTTTTTCGACCGCGCAAAAGCTCGACAAACTCGGTATGCGCGGTTCCAACACCTGCGAACTGGTGT
TCGAGGATTGCGAAGTGCCAGCCGAAAACCTGCTCGGAACCGAGGGCAAGGGCGTCAATGTGCTGATGTCCGGCCTCGAT
TATGAGCGCGTGGTGCTGGCGGGTGGGCCGCTCGGCATCATGGCGGCCTGCCTCGATGTCGTGGTGCCCTATGTGCATGA
GCGCAAGCAGTTCGACCAGCCAATCGGTGAATTCCAGCTCATGCAGTGCAAGCTTGCCGACATGTATGTGACCTTCAACG
CTTCACGCGCTTATGTCTATGCCGTGGCCGCAGCCTGCGACCGGGGTGAGACGACGCGCAAGGATGCGGCGGGCTGCATT
CTTTACTCTGCGGAAAATGCCACGCAGATGGCCTTGCAGGCGATCCAGTCTCTCGGCGGCAACGGCTATATCAACGATTA
TCCGACGGGCCGCCTTTTGCGCGATGCCAAGCTTTATGAAATCGGCGCGGGCACGTCGGAAATCCGGCGTATGCTGATCG
GACGGGAACTCTTTCAGGAGACCCGTTGA

Upstream 100 bases:

>100_bases
CGGGACACTCTGGCCGGGACATAGCTGTTCTCGAAAAACAGCAGCCGGGCAGAACTTGTGGAGGACGAGTATGTTTGCTT
TGGGTCAAAATGGAGGGGGG

Downstream 100 bases:

>100_bases
TGCCGGTTCTGAAATCTGAAATCTCGACGCGCAGCGCAAGCTTCGAGGCCAACCGCAAGGCCATGCTGGCGGCAATCGAC
GTGGTGGCGGAAGCCTCGCG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHCIAMEEISRAS
ASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNG
PDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLD
YERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGETTRKDAAGCI
LYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR

Sequences:

>Translated_382_residues
MNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHCIAMEEISRAS
ASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNG
PDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLD
YERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGETTRKDAAGCI
LYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR
>Mature_382_residues
MNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHCIAMEEISRAS
ASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNG
PDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLD
YERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGETTRKDAAGCI
LYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=68.6170212765958, Blast_Score=537, Evalue=1e-153,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=67.2972972972973, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=41.005291005291, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=34.4262295081967, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=35.3562005277045, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=35.3562005277045, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=37.7094972067039, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=34.2036553524804, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=34.1333333333333, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=33.5120643431635, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=33.5120643431635, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=33.1564986737401, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=33.7801608579088, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=25.1748251748252, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=25.1748251748252, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=23.021582733813, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI218563752, Length=227, Percent_Identity=25.5506607929515, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=29.242819843342, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=29.242819843342, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=28.957528957529, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081702, Length=335, Percent_Identity=24.1791044776119, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=65.5263157894737, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17506239, Length=369, Percent_Identity=33.8753387533875, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=34.2318059299191, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=34.8167539267016, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.1207349081365, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=32.5459317585302, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=38.8489208633094, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=34.0909090909091, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=31.25, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=31.8801089918256, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=30.3191489361702, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.3636363636364, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=34.0277777777778, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.2116788321168, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=28.3154121863799, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=28.3154121863799, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=64.3229166666667, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=41.7553191489362, Blast_Score=300, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.563829787234, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=35.9375, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=33.9622641509434, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=33.983286908078, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.7082228116711, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41423; Mature: 41423

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCC
GAGMGYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHV
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC
GALAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYAKTDLSAGPRG
CEEEECCCCCCCCCEEEEEHHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCCCCC
ISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLD
CEEHEEHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCCEEEECCCC
YERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVY
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEEEEEECCCEEEE
AVAAACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYE
EEEHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEE
IGAGTSEIRRMLIGRELFQETR
ECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCC
GAGMGYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHV
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCC
GALAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYAKTDLSAGPRG
CEEEECCCCCCCCCEEEEEHHHCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCCCCC
ISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLD
CEEHEEHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCCEEEECCCC
YERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVY
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEEEEEEECCCEEEE
AVAAACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYE
EEEHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEE
IGAGTSEIRRMLIGRELFQETR
ECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]