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The map label for this gene is yngE [H]

Identifier: 23500934

GI number: 23500934

Start: 21257

End: 22864

Strand: Reverse

Name: yngE [H]

Synonym: BR0019

Alternate gene names: 23500934

Gene position: 22864-21257 (Counterclockwise)

Preceding gene: 23500935

Following gene: 23500933

Centisome position: 1.08

GC content: 62.25

Gene sequence:

>1608_bases
ATGCCGGTTCTGAAATCTGAAATCTCGACGCGCAGCGCAAGCTTCGAGGCCAACCGCAAGGCCATGCTGGCGGCAATCGA
CGTGGTGGCGGAAGCCTCGCGCATTGCCATTGACGGCGGCGGCGAGAAAGCGCGCGACCGCCATGTTTCGCGCGGAAAAC
TTCTGCCCCGTGAGCGCGTGGCGCAATTGCTCGATCCGGGTTCCCCCTTTCTGGAACTGGGGCTGACGGCAGCGCATGGC
ACGTATGGCGGGGCAGCGCCCGCCGCTGGCATCATCACCGGCATCGGGCGCGTATCGGGCCGCGAATGCATGATCGTCTG
CAATGATGCGACGGTAAAGGGTGGCACCTATTATCCGATGACGGTGAAAAAGCATCTGCGCGCGCAGGAGATTGCAGGCG
AAAATCGCCTGCCCTGCATTTATCTGGTCGATTCCGGCGGCGCGAACCTGCCCAATCAGGATGAGGTTTTCCCGGATCGC
GACCATTTCGGACGCATTTTCTACAATCAGGCGCAGATGTCGGCGGCAGGCATTCCGCAGGTGGCCGTGGTCATGGGATC
ATGCACGGCAGGCGGCGCTTACGTACCCGCCATGAGCGACGAGACGGTGATCGTGCGGGGCCAAGGCACGATCTTTCTGG
CAGGCCCCCCTCTGGTCAAGGCTGCAACCGGCGAAGTGGTGAGCGCGGAAGATCTTGGCGGTGGCGATGTACACACCCGG
CTTTCCGGCGTGGCGGATCATCTTGCCAATGACGATGCACACGCCTTGCAGATCGCACGCGCCATTGCCGCTAATCTGGC
TAGCGAGAAGCGCTCGTTCATTCCAAGAGGCGACGGCGCTGCCCCGCTTTACGACCCGGAAGAACTGCTCGGCGTCGTTT
CCGCCGATACGCGCATTCCCTATGATGTGCGCGAGGTGATCGCGCGGCTGGTCGATGGCTCCGATTTCGATGAGTTCAAG
GCGCGCTACGGCACAACTTTGGTCTGCGGTTTTGCCAGCGTCTACGGCATGCCGGTCGGCATTATTGCCAATAATGGCGT
GCTGTTTTCCGAAGCAGCACTCAAGGGCGCGCATTTCATCGAGCTTTGCTGCCAGCGCAATATTCCGCTGGTGTTTTTGC
AAAATATCACCGGCTTTATGGTCGGGCGCAAATATGAGGCCGAAGGCATTGCCAAGCACGGCGCCAAACTGGTGACGGCG
GTGGCGACCGCCAATGTGCCGAAGATCACCATGCTGATCGGCGCGTCCTATGGCGCGGGCAATTACGGCATGGCGGGACG
GGCCTATTCGCCGCGCTTCCTGTGGACCTGGCCGAACAGCCGCATTGCGGTGATGGGCGGCGAGCAGGCGGCAGGCGTGC
TGGCAACCGTCAAGCGCGACGGGATCGAGCGCACCGGCGGCACATGGTCGGCGGAAGAGGAAGCGGAGTTCAAGCGCCCG
ACGCTCGAAATGTTCGAGCGCCAGAGCCACCCGCTCTATGCCTCGGCGCGGCTTTGGGATGACGGCATCGTCGATCCGCG
CAAGAGCCGCGAAGTGCTTGGCCTGCCGCTTTCCGCCACGCTGAACGCGCCGGTCGAGCCGACGCGTTTTGGCATCTTCA
GAATGTGA

Upstream 100 bases:

>100_bases
GCCGCCTTTTGCGCGATGCCAAGCTTTATGAAATCGGCGCGGGCACGTCGGAAATCCGGCGTATGCTGATCGGACGGGAA
CTCTTTCAGGAGACCCGTTG

Downstream 100 bases:

>100_bases
GGAAGCGCGGGATGAGGAAAAGTGTGAAGCGGTTTTCCGCCCGCATCCCGCGAGGAAAAAATGCGATGTTTCAGAAAATA
CTGATTGCCAATCGCGGAGA

Product: carboxyl transferase family protein

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPVLKSEISTRSASFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHG
TYGGAAPAAGIITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFK
ARYGTTLVCGFASVYGMPVGIIANNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTA
VATANVPKITMLIGASYGAGNYGMAGRAYSPRFLWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLPLSATLNAPVEPTRFGIFRM

Sequences:

>Translated_535_residues
MPVLKSEISTRSASFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHG
TYGGAAPAAGIITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFK
ARYGTTLVCGFASVYGMPVGIIANNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTA
VATANVPKITMLIGASYGAGNYGMAGRAYSPRFLWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLPLSATLNAPVEPTRFGIFRM
>Mature_534_residues
PVLKSEISTRSASFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHGT
YGGAAPAAGIITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFKA
RYGTTLVCGFASVYGMPVGIIANNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAV
ATANVPKITMLIGASYGAGNYGMAGRAYSPRFLWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRPT
LEMFERQSHPLYASARLWDDGIVDPRKSREVLGLPLSATLNAPVEPTRFGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=66.0952380952381, Blast_Score=695, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=516, Percent_Identity=31.5891472868217, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=30.6967984934087, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=62.2222222222222, Blast_Score=147, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17552936, Length=536, Percent_Identity=62.3134328358209, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=544, Percent_Identity=33.4558823529412, Blast_Score=245, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI25147359, Length=548, Percent_Identity=33.029197080292, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=63.0909090909091, Blast_Score=706, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 56950; Mature: 56818

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLKSEISTRSASFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERV
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHH
AQLLDPGSPFLELGLTAAHGTYGGAAPAAGIITGIGRVSGRECMIVCNDATVKGGTYYPM
HHHHCCCCCHHHHCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAAGIPQ
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEHHHHHHCCCCE
VAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEHCCCCCCC
YDVREVIARLVDGSDFDEFKARYGTTLVCGFASVYGMPVGIIANNGVLFSEAALKGAHFI
HHHHHHHHHHHCCCCHHHHHHHHCCEEEEHHHHHHCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAVATANVPKITMLIGASYGAG
HHHHCCCCCEEEECCCCHHHCCCEECCCHHHHCCHHEEEHHHHCCCCEEEEEEECCCCCC
NYGMAGRAYSPRFLWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCC
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLPLSATLNAPVEPTRFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCEECC
>Mature Secondary Structure 
PVLKSEISTRSASFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERV
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHH
AQLLDPGSPFLELGLTAAHGTYGGAAPAAGIITGIGRVSGRECMIVCNDATVKGGTYYPM
HHHHCCCCCHHHHCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAAGIPQ
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEHHHHHHCCCCE
VAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEHCCCCCCC
YDVREVIARLVDGSDFDEFKARYGTTLVCGFASVYGMPVGIIANNGVLFSEAALKGAHFI
HHHHHHHHHHHCCCCHHHHHHHHCCEEEEHHHHHHCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAVATANVPKITMLIGASYGAG
HHHHCCCCCEEEECCCCHHHCCCEECCCHHHHCCHHEEEHHHHCCCCEEEEEEECCCCCC
NYGMAGRAYSPRFLWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCC
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLPLSATLNAPVEPTRFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]