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The map label for this gene is malR [H]

Identifier: 23100674

GI number: 23100674

Start: 3351849

End: 3352562

Strand: Reverse

Name: malR [H]

Synonym: OB3219

Alternate gene names: 23100674

Gene position: 3352562-3351849 (Counterclockwise)

Preceding gene: 23100675

Following gene: 23100673

Centisome position: 92.34

GC content: 38.1

Gene sequence:

>714_bases
ATGATTCGGGTACTAATTGTAGAAGATGATCCAATGGTAGCGGAATTTAATAAAAGATATATACAGCTTATCGATGGATT
CGAAGTAACAGCGATCGCAACCAACACAGCGGAAGCGAAGGCAACCATGGAACAGCAAACGGTTGAGTTATTATTGCTTG
ATGTATATATGCCAGATGAAAATGGATTAGCGCTCCTATCTCATATTCGAAGTGTGGGCATAGAGGTCGATGTAATATTA
ATAACGGCCGCATCAGACAAAGAACGAATACAGCAAGCCCTGCGATTTGGTGCTGTAGATTATTTGATTAAACCATTTGA
ATTTGAGCGATTAGAACAATCCCTACTTGCTTATAAAGAAAAACATGAATTATTATTGGATAAAGAGGTAATGACGCAAA
AGGAATTGGACAAGTTTATGCATGCGGAAGAAGAAGCTGGTGAACCAGAAAAAATATTGCCAAAAGGTCTGACAGAGTCA
ACGTTACAAGTGATTGTATCTGAAATCAGACGTCAGCACGGCGTATTTTTCTCCACAGATGAATTAGCAGAGCAAACCAA
TATTTCTCGTGTTTCTATCCGTAAATATTTAAAGTTTTTAGTAGATATTGATTGGGTCGAAGAGAAGATGACGTATGGAA
TAGGGCGACCTGTCTATTCGTACCAATACAAAAGAGAAAATGATCATCACTTATACCCGTATATCAGCAGCTAA

Upstream 100 bases:

>100_bases
AGAGTGTAGAGACGTTGGGTGGATCCTTGCGTTTTGAAACACTTGAAGCTGGAACTATTTTTGAAGTCGAAGTTCCTTAT
CAGATAAGGAGAGATATACA

Downstream 100 bases:

>100_bases
TACATAATTAGCTGCTTTTTTTAATTTCAAAACTCTTTTAATAGTTTCAAAACCGTTCAATTTTTTGTCAACTATTTATA
ATAAAAAAGAAATCGAATTG

Product: truncated two-component response regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIRVLIVEDDPMVAEFNKRYIQLIDGFEVTAIATNTAEAKATMEQQTVELLLLDVYMPDENGLALLSHIRSVGIEVDVIL
ITAASDKERIQQALRFGAVDYLIKPFEFERLEQSLLAYKEKHELLLDKEVMTQKELDKFMHAEEEAGEPEKILPKGLTES
TLQVIVSEIRRQHGVFFSTDELAEQTNISRVSIRKYLKFLVDIDWVEEKMTYGIGRPVYSYQYKRENDHHLYPYISS

Sequences:

>Translated_237_residues
MIRVLIVEDDPMVAEFNKRYIQLIDGFEVTAIATNTAEAKATMEQQTVELLLLDVYMPDENGLALLSHIRSVGIEVDVIL
ITAASDKERIQQALRFGAVDYLIKPFEFERLEQSLLAYKEKHELLLDKEVMTQKELDKFMHAEEEAGEPEKILPKGLTES
TLQVIVSEIRRQHGVFFSTDELAEQTNISRVSIRKYLKFLVDIDWVEEKMTYGIGRPVYSYQYKRENDHHLYPYISS
>Mature_237_residues
MIRVLIVEDDPMVAEFNKRYIQLIDGFEVTAIATNTAEAKATMEQQTVELLLLDVYMPDENGLALLSHIRSVGIEVDVIL
ITAASDKERIQQALRFGAVDYLIKPFEFERLEQSLLAYKEKHELLLDKEVMTQKELDKFMHAEEEAGEPEKILPKGLTES
TLQVIVSEIRRQHGVFFSTDELAEQTNISRVSIRKYLKFLVDIDWVEEKMTYGIGRPVYSYQYKRENDHHLYPYISS

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=230, Percent_Identity=41.7391304347826, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1786838, Length=222, Percent_Identity=34.6846846846847, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1787229, Length=159, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=36.697247706422, Blast_Score=60, Evalue=9e-11,
Organism=Escherichia coli, GI1787487, Length=116, Percent_Identity=31.8965517241379, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27463; Mature: 27463

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLIVEDDPMVAEFNKRYIQLIDGFEVTAIATNTAEAKATMEQQTVELLLLDVYMPDE
CEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHEEEEEEEECCC
NGLALLSHIRSVGIEVDVILITAASDKERIQQALRFGAVDYLIKPFEFERLEQSLLAYKE
CCHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHH
KHELLLDKEVMTQKELDKFMHAEEEAGEPEKILPKGLTESTLQVIVSEIRRQHGVFFSTD
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCEECHH
ELAEQTNISRVSIRKYLKFLVDIDWVEEKMTYGIGRPVYSYQYKRENDHHLYPYISS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCEECCEECC
>Mature Secondary Structure
MIRVLIVEDDPMVAEFNKRYIQLIDGFEVTAIATNTAEAKATMEQQTVELLLLDVYMPDE
CEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHEEEEEEEECCC
NGLALLSHIRSVGIEVDVILITAASDKERIQQALRFGAVDYLIKPFEFERLEQSLLAYKE
CCHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHH
KHELLLDKEVMTQKELDKFMHAEEEAGEPEKILPKGLTESTLQVIVSEIRRQHGVFFSTD
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCEECHH
ELAEQTNISRVSIRKYLKFLVDIDWVEEKMTYGIGRPVYSYQYKRENDHHLYPYISS
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]