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The map label for this gene is maeB [C]

Identifier: 23100673

GI number: 23100673

Start: 3350531

End: 3351721

Strand: Reverse

Name: maeB [C]

Synonym: OB3218

Alternate gene names: 23100673

Gene position: 3351721-3350531 (Counterclockwise)

Preceding gene: 23100674

Following gene: 23100672

Centisome position: 92.32

GC content: 39.21

Gene sequence:

>1191_bases
GTGGTATATAAAAATTTAAAAGATGAAGCAATTGAACTTCATTATAAGCATAAAGGAAAGTTAGAAATCACAGGGAAAAT
GGAAATCAATACGGAAGACGATTTAAGTCTTGTGTATACACCTGGAGTAGCGGATGTATGTAAACAAATTGCCGATGACC
CGAACAAAATCAATACACTTACATCTCGTGGGAATATGGTAGGGATTGTAACAGACGGTACAGCAGTACTTGGTCTGGGA
AATATTGGACCAAAAGCAGCAATGCCTGTAATGGAAGGAAAAGCACTATTGTTTAAGAAATTCGCTAATATTGATGGATT
TCCTATTTGTTTAGATACGACGGATGTAGATGAAATTGTAAATATTGTAAAAGCAATGGGACCAACGTTTGCAGGGATTA
ATCTTGAAGATATTGCAGCTCCTCGTTGTTTTGAAATCGAAAAACGTCTGAAAGAGGAATTAGATATTCCCGTATTCCAT
GATGACCAGCATGGAACTGCAATTGTTGTACTAGCAGCATTAACGAATGCTTTAAAAGTGGTAAACAAACAGAATCGCCC
TATTAAAATTGTCATTAATGGTGCTGGTGCAGCAGGAATTGCAATAGCGAAGCTACTCTATCATGCGGGATTAACTAATA
TTACGTTAGTAAGCTTAGAAGGCGTGGTAGCAAAAGGCGAAGATTGGTTAAATCCAATGCAGGTAGAAATGGCAGAAGTA
ACAAATAAAGATAATGTTCGTGGCACGTTGAAAGATGCGATTACAGAAGCAGATGTATTTATCGGTGTATCTGGTCCTGG
AGCATTAAAGAAAGAACATATTCAAACAATGGCGAAGGATCCAATTATTTTTGCGCTAGCGAATCCAATTCCAGAAATCT
ACCCAGAAGAGGCATTGGAAGCTGGTGCAGCAGTAGTAGCAACGGGCCGTTCGGATTATCCGAATCAGGTCAATAACTTA
CTTGCATTTCCAGGGATATTCCGAGGAGCAATTGATGCGGGAGCAAGGGATATTACAACCGAAATGAAGGTAGCTGCAGC
TTATGGGATTGCAGATGTATTATCAGATGAAGAGATTTCTAAAGATAAAGTTATCCCAAATGCCTTGGATGAGCGAGCAG
GTGAACGTGTTGCACAAGCTGTTATGTCGAGTGCTATCCAACAGAAAAAGGAAACAAGCTCTGTAAGTTAA

Upstream 100 bases:

>100_bases
CAAAACTCTTTTAATAGTTTCAAAACCGTTCAATTTTTTGTCAACTATTTATAATAAAAAAGAAATCGAATTGAAAGCGA
TTACGGTGGGGGTAATTATT

Downstream 100 bases:

>100_bases
TGTAAGAGGGGGAAGAGCCTTCCTTCTAATTTTGAGGAAGGCTCTTCAAAAATAAAACCGAAAGAGAAAGGTGAACAAAA
TGAAAGAATCTACAGAAATG

Product: malate oxidoreductase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MVYKNLKDEAIELHYKHKGKLEITGKMEINTEDDLSLVYTPGVADVCKQIADDPNKINTLTSRGNMVGIVTDGTAVLGLG
NIGPKAAMPVMEGKALLFKKFANIDGFPICLDTTDVDEIVNIVKAMGPTFAGINLEDIAAPRCFEIEKRLKEELDIPVFH
DDQHGTAIVVLAALTNALKVVNKQNRPIKIVINGAGAAGIAIAKLLYHAGLTNITLVSLEGVVAKGEDWLNPMQVEMAEV
TNKDNVRGTLKDAITEADVFIGVSGPGALKKEHIQTMAKDPIIFALANPIPEIYPEEALEAGAAVVATGRSDYPNQVNNL
LAFPGIFRGAIDAGARDITTEMKVAAAYGIADVLSDEEISKDKVIPNALDERAGERVAQAVMSSAIQQKKETSSVS

Sequences:

>Translated_396_residues
MVYKNLKDEAIELHYKHKGKLEITGKMEINTEDDLSLVYTPGVADVCKQIADDPNKINTLTSRGNMVGIVTDGTAVLGLG
NIGPKAAMPVMEGKALLFKKFANIDGFPICLDTTDVDEIVNIVKAMGPTFAGINLEDIAAPRCFEIEKRLKEELDIPVFH
DDQHGTAIVVLAALTNALKVVNKQNRPIKIVINGAGAAGIAIAKLLYHAGLTNITLVSLEGVVAKGEDWLNPMQVEMAEV
TNKDNVRGTLKDAITEADVFIGVSGPGALKKEHIQTMAKDPIIFALANPIPEIYPEEALEAGAAVVATGRSDYPNQVNNL
LAFPGIFRGAIDAGARDITTEMKVAAAYGIADVLSDEEISKDKVIPNALDERAGERVAQAVMSSAIQQKKETSSVS
>Mature_396_residues
MVYKNLKDEAIELHYKHKGKLEITGKMEINTEDDLSLVYTPGVADVCKQIADDPNKINTLTSRGNMVGIVTDGTAVLGLG
NIGPKAAMPVMEGKALLFKKFANIDGFPICLDTTDVDEIVNIVKAMGPTFAGINLEDIAAPRCFEIEKRLKEELDIPVFH
DDQHGTAIVVLAALTNALKVVNKQNRPIKIVINGAGAAGIAIAKLLYHAGLTNITLVSLEGVVAKGEDWLNPMQVEMAEV
TNKDNVRGTLKDAITEADVFIGVSGPGALKKEHIQTMAKDPIIFALANPIPEIYPEEALEAGAAVVATGRSDYPNQVNNL
LAFPGIFRGAIDAGARDITTEMKVAAAYGIADVLSDEEISKDKVIPNALDERAGERVAQAVMSSAIQQKKETSSVS

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=441, Percent_Identity=25.1700680272109, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4505145, Length=418, Percent_Identity=27.511961722488, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI62420882, Length=416, Percent_Identity=25.4807692307692, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62420880, Length=416, Percent_Identity=25.4807692307692, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI239049447, Length=416, Percent_Identity=25.4807692307692, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI270265879, Length=377, Percent_Identity=27.8514588859416, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788806, Length=410, Percent_Identity=45.8536585365854, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87081919, Length=441, Percent_Identity=27.2108843537415, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17537199, Length=424, Percent_Identity=26.1792452830189, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=307, Percent_Identity=28.9902280130293, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24646388, Length=412, Percent_Identity=26.9417475728155, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646386, Length=420, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI78707232, Length=436, Percent_Identity=26.8348623853211, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363505, Length=436, Percent_Identity=26.8348623853211, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78707236, Length=436, Percent_Identity=26.8348623853211, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281363503, Length=436, Percent_Identity=26.8348623853211, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78707242, Length=440, Percent_Identity=25.9090909090909, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707238, Length=440, Percent_Identity=25.9090909090909, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707240, Length=433, Percent_Identity=26.3279445727483, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356279, Length=426, Percent_Identity=25.5868544600939, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281362672, Length=426, Percent_Identity=25.5868544600939, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281362674, Length=426, Percent_Identity=25.5868544600939, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 42337; Mature: 42337

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYKNLKDEAIELHYKHKGKLEITGKMEINTEDDLSLVYTPGVADVCKQIADDPNKINTL
CCCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCEEEECCCHHHHHHHHCCCCHHHHHE
TSRGNMVGIVTDGTAVLGLGNIGPKAAMPVMEGKALLFKKFANIDGFPICLDTTDVDEIV
ECCCCEEEEEECCEEEEEECCCCCHHCCCHHCCHHHHHHHHCCCCCCEEEECCCCHHHHH
NIVKAMGPTFAGINLEDIAAPRCFEIEKRLKEELDIPVFHDDQHGTAIVVLAALTNALKV
HHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VNKQNRPIKIVINGAGAAGIAIAKLLYHAGLTNITLVSLEGVVAKGEDWLNPMQVEMAEV
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCHHCCHHHHHHHHH
TNKDNVRGTLKDAITEADVFIGVSGPGALKKEHIQTMAKDPIIFALANPIPEIYPEEALE
CCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
AGAAVVATGRSDYPNQVNNLLAFPGIFRGAIDAGARDITTEMKVAAAYGIADVLSDEEIS
CCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KDKVIPNALDERAGERVAQAVMSSAIQQKKETSSVS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVYKNLKDEAIELHYKHKGKLEITGKMEINTEDDLSLVYTPGVADVCKQIADDPNKINTL
CCCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCEEEECCCHHHHHHHHCCCCHHHHHE
TSRGNMVGIVTDGTAVLGLGNIGPKAAMPVMEGKALLFKKFANIDGFPICLDTTDVDEIV
ECCCCEEEEEECCEEEEEECCCCCHHCCCHHCCHHHHHHHHCCCCCCEEEECCCCHHHHH
NIVKAMGPTFAGINLEDIAAPRCFEIEKRLKEELDIPVFHDDQHGTAIVVLAALTNALKV
HHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
VNKQNRPIKIVINGAGAAGIAIAKLLYHAGLTNITLVSLEGVVAKGEDWLNPMQVEMAEV
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCHHCCHHHHHHHHH
TNKDNVRGTLKDAITEADVFIGVSGPGALKKEHIQTMAKDPIIFALANPIPEIYPEEALE
CCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHH
AGAAVVATGRSDYPNQVNNLLAFPGIFRGAIDAGARDITTEMKVAAAYGIADVLSDEEIS
CCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KDKVIPNALDERAGERVAQAVMSSAIQQKKETSSVS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]