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The map label for this gene is pepQ [H]

Identifier: 23100284

GI number: 23100284

Start: 2908177

End: 2909307

Strand: Direct

Name: pepQ [H]

Synonym: OB2829

Alternate gene names: 23100284

Gene position: 2908177-2909307 (Clockwise)

Preceding gene: 23100283

Following gene: 23100285

Centisome position: 80.1

GC content: 35.54

Gene sequence:

>1131_bases
TTGCAAACCAAAAATAGAGTTGATAACTTAAGAGCAATTATGGAGGAAAGTAATATTGATTTGTCCATCATTATGAACGT
TGAAAATCAATATTATCTAAACGGTTTAAAGGCTATTACTTACTCACGTCCAATCGTCCTTGCGATTGATTCAAAAAATC
TCAGTTTAATTATCCCTTCATTGGAAGAAAATCACGCAAAAGAAAAGACAGACGCAAATGAACTCTATATTTACCATGAA
ACAAACCTTTATGGAGGTGACAAAAAATCTTATTTGGATTACTTGGAAACGGTCATTTCTCAATATCCGAATGGAACGAG
AGTCGGAGTGGAATTTTCATCCTTATCGTTGAAAATGGCAAATATACTAAAAGAAGCTGGTTTTGAACTGATTAATTTAG
ATCACAAAATAGCAGAGATGCGGTTTATTAAGAACGATGAAGAAATTGAAATGGTGCAGGAGGCAGGAAAATTAGTAAGT
TTAGCCTTAAAAAAATCATTGGAAAATGCTCAACCAGGTATAACCGAGATGGAGCTGGATCGTCATGGCACACAACTGTT
ATTTGAAGAAATGGATAACTATCCAGATGCTACTCTTGATTATTTTGCCATGTCGCCCTCTGGTTTAGAGAGAAGCATTA
TGCCGCATGTTTTTTCTAATACTAGAAAACTATTAACTAATGACATTGTTGTTCATAGTAGACAAGTTGCCTTAAATGGT
TATCGCGCGGAATGTGAAAGAACATTTTTTGTAGGAAAACCAACAGACAAACAATTAGATGCATTTAAAGCGGCATATGA
AGCACAGTTAGTGGCAATGGAAAAAATAGCCGTTGGAGTTACCGCGAAAGAAGTAGATGAAGTGGCAAGGAATATCTTTC
AACAATACAATTTAGAAAAATATTGTATTCATCGAACTGGTCATGGTATCGGTATTGGTCTCCATGAAGAACCTTCCCTT
CGTTTTGATAATGATCTCGTCTTACAAGAAGGAATGATCTTTACTATTGAACCAGGAATATATATTCCTGGAGTTGGTGG
ATTCAGGCACTCCGATACGGTAGTCCTAACCAATGAGGGAACAAAACTAGTAACAGAATACCCGAGAGAAATTGAGCATT
TAATATTTTAA

Upstream 100 bases:

>100_bases
TCCTTGATTTCTATTCCTATCGCGATATTAGTATTAGTTATTGTAACTTTACTTACTTCAAAAAAACAAGAATTATTCGA
CTATAGAAAGGATGATTTAA

Downstream 100 bases:

>100_bases
TAGATAGAGTGTAAAGCAACATGGAAAAGATGAAGAGGTTGAGACAAAAGTTATATTCAAATGATAGATTTTTAAATCTC
CGCTTATCCACTAGCGGCTA

Product: cobalt dependent X-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MQTKNRVDNLRAIMEESNIDLSIIMNVENQYYLNGLKAITYSRPIVLAIDSKNLSLIIPSLEENHAKEKTDANELYIYHE
TNLYGGDKKSYLDYLETVISQYPNGTRVGVEFSSLSLKMANILKEAGFELINLDHKIAEMRFIKNDEEIEMVQEAGKLVS
LALKKSLENAQPGITEMELDRHGTQLLFEEMDNYPDATLDYFAMSPSGLERSIMPHVFSNTRKLLTNDIVVHSRQVALNG
YRAECERTFFVGKPTDKQLDAFKAAYEAQLVAMEKIAVGVTAKEVDEVARNIFQQYNLEKYCIHRTGHGIGIGLHEEPSL
RFDNDLVLQEGMIFTIEPGIYIPGVGGFRHSDTVVLTNEGTKLVTEYPREIEHLIF

Sequences:

>Translated_376_residues
MQTKNRVDNLRAIMEESNIDLSIIMNVENQYYLNGLKAITYSRPIVLAIDSKNLSLIIPSLEENHAKEKTDANELYIYHE
TNLYGGDKKSYLDYLETVISQYPNGTRVGVEFSSLSLKMANILKEAGFELINLDHKIAEMRFIKNDEEIEMVQEAGKLVS
LALKKSLENAQPGITEMELDRHGTQLLFEEMDNYPDATLDYFAMSPSGLERSIMPHVFSNTRKLLTNDIVVHSRQVALNG
YRAECERTFFVGKPTDKQLDAFKAAYEAQLVAMEKIAVGVTAKEVDEVARNIFQQYNLEKYCIHRTGHGIGIGLHEEPSL
RFDNDLVLQEGMIFTIEPGIYIPGVGGFRHSDTVVLTNEGTKLVTEYPREIEHLIF
>Mature_376_residues
MQTKNRVDNLRAIMEESNIDLSIIMNVENQYYLNGLKAITYSRPIVLAIDSKNLSLIIPSLEENHAKEKTDANELYIYHE
TNLYGGDKKSYLDYLETVISQYPNGTRVGVEFSSLSLKMANILKEAGFELINLDHKIAEMRFIKNDEEIEMVQEAGKLVS
LALKKSLENAQPGITEMELDRHGTQLLFEEMDNYPDATLDYFAMSPSGLERSIMPHVFSNTRKLLTNDIVVHSRQVALNG
YRAECERTFFVGKPTDKQLDAFKAAYEAQLVAMEKIAVGVTAKEVDEVARNIFQQYNLEKYCIHRTGHGIGIGLHEEPSL
RFDNDLVLQEGMIFTIEPGIYIPGVGGFRHSDTVVLTNEGTKLVTEYPREIEHLIF

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40385867, Length=254, Percent_Identity=25.9842519685039, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788728, Length=238, Percent_Identity=28.9915966386555, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789275, Length=287, Percent_Identity=26.1324041811847, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=30.9178743961353, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71989583, Length=285, Percent_Identity=25.6140350877193, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320922, Length=268, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 42680; Mature: 42680

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKNRVDNLRAIMEESNIDLSIIMNVENQYYLNGLKAITYSRPIVLAIDSKNLSLIIPS
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCEEEEEECCCEEEEECCCCCEEEECC
LEENHAKEKTDANELYIYHETNLYGGDKKSYLDYLETVISQYPNGTRVGVEFSSLSLKMA
CCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
NILKEAGFELINLDHKIAEMRFIKNDEEIEMVQEAGKLVSLALKKSLENAQPGITEMELD
HHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
RHGTQLLFEEMDNYPDATLDYFAMSPSGLERSIMPHVFSNTRKLLTNDIVVHSRQVALNG
CCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECC
YRAECERTFFVGKPTDKQLDAFKAAYEAQLVAMEKIAVGVTAKEVDEVARNIFQQYNLEK
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YCIHRTGHGIGIGLHEEPSLRFDNDLVLQEGMIFTIEPGIYIPGVGGFRHSDTVVLTNEG
EEEEECCCEEEECCCCCCCCCCCCCEEEECCEEEEECCCEEECCCCCCCCCCEEEEECCC
TKLVTEYPREIEHLIF
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTKNRVDNLRAIMEESNIDLSIIMNVENQYYLNGLKAITYSRPIVLAIDSKNLSLIIPS
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCEEEEEECCCEEEEECCCCCEEEECC
LEENHAKEKTDANELYIYHETNLYGGDKKSYLDYLETVISQYPNGTRVGVEFSSLSLKMA
CCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHH
NILKEAGFELINLDHKIAEMRFIKNDEEIEMVQEAGKLVSLALKKSLENAQPGITEMELD
HHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
RHGTQLLFEEMDNYPDATLDYFAMSPSGLERSIMPHVFSNTRKLLTNDIVVHSRQVALNG
CCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECEEEEECC
YRAECERTFFVGKPTDKQLDAFKAAYEAQLVAMEKIAVGVTAKEVDEVARNIFQQYNLEK
EECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YCIHRTGHGIGIGLHEEPSLRFDNDLVLQEGMIFTIEPGIYIPGVGGFRHSDTVVLTNEG
EEEEECCCEEEECCCCCCCCCCCCCEEEECCEEEEECCCEEECCCCCCCCCCEEEEECCC
TKLVTEYPREIEHLIF
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]